Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls.

Published

Journal Article

Meningioma, the most frequent tumor in the central nervous system, has few recognized risk factors. We explored the role of allergies in a population-based case-control consortium study of meningioma in five geographic areas. We also studied serum levels of a marker of atopic allergy (IgE) in a subset of study participants, a first for a study on meningioma. Participants (N = 1,065) with surgically resected, pathologically confirmed meningioma and controls (N = 634) selected via random-digit dialing were recruited and interviewed. Cases were less likely than controls to report history of physician-diagnosed allergy [odds ratio (OR) = 0.64; 95% confidence interval (95% CI): 0.51-0.80]. Also, cases (N = 295) had lower total serum IgE than controls [N = 192; OR = 0.85, 95% CI: 0.75-0.98 for each unit of Ln(IgE)]. Similar to glioma and cancers at several other sites, meningioma appears to have an inverse relationship with history of allergies and a biomarker of atopic allergy. As some common opposing predisposition or developmental processes for allergy and meningioma may exist, further research into immune processes that can affect the incidence and natural history of meningioma is warranted.

Full Text

Duke Authors

Cited Authors

  • Wiemels, JL; Wrensch, M; Sison, JD; Zhou, M; Bondy, M; Calvocoressi, L; Black, PM; Yu, H; Schildkraut, JM; Claus, EB

Published Date

  • October 2011

Published In

Volume / Issue

  • 129 / 8

Start / End Page

  • 1932 - 1939

PubMed ID

  • 21520030

Pubmed Central ID

  • 21520030

Electronic International Standard Serial Number (EISSN)

  • 1097-0215

International Standard Serial Number (ISSN)

  • 0020-7136

Digital Object Identifier (DOI)

  • 10.1002/ijc.25858

Language

  • eng