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Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls.

Publication ,  Journal Article
Wiemels, JL; Wrensch, M; Sison, JD; Zhou, M; Bondy, M; Calvocoressi, L; Black, PM; Yu, H; Schildkraut, JM; Claus, EB
Published in: Int J Cancer
October 15, 2011

Meningioma, the most frequent tumor in the central nervous system, has few recognized risk factors. We explored the role of allergies in a population-based case-control consortium study of meningioma in five geographic areas. We also studied serum levels of a marker of atopic allergy (IgE) in a subset of study participants, a first for a study on meningioma. Participants (N = 1,065) with surgically resected, pathologically confirmed meningioma and controls (N = 634) selected via random-digit dialing were recruited and interviewed. Cases were less likely than controls to report history of physician-diagnosed allergy [odds ratio (OR) = 0.64; 95% confidence interval (95% CI): 0.51-0.80]. Also, cases (N = 295) had lower total serum IgE than controls [N = 192; OR = 0.85, 95% CI: 0.75-0.98 for each unit of Ln(IgE)]. Similar to glioma and cancers at several other sites, meningioma appears to have an inverse relationship with history of allergies and a biomarker of atopic allergy. As some common opposing predisposition or developmental processes for allergy and meningioma may exist, further research into immune processes that can affect the incidence and natural history of meningioma is warranted.

Duke Scholars

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Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

October 15, 2011

Volume

129

Issue

8

Start / End Page

1932 / 1939

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Middle Aged
  • Meningioma
  • Meningeal Neoplasms
  • Male
  • Immunoglobulin E
  • Hypersensitivity
  • Humans
  • Female
  • Case-Control Studies
 

Citation

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Wiemels, J. L., Wrensch, M., Sison, J. D., Zhou, M., Bondy, M., Calvocoressi, L., … Claus, E. B. (2011). Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls. Int J Cancer, 129(8), 1932–1939. https://doi.org/10.1002/ijc.25858
Wiemels, Joseph L., Margaret Wrensch, Jennette D. Sison, Mi Zhou, Melissa Bondy, Lisa Calvocoressi, Peter M. Black, Herbert Yu, Joellen M. Schildkraut, and Elizabeth B. Claus. “Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls.Int J Cancer 129, no. 8 (October 15, 2011): 1932–39. https://doi.org/10.1002/ijc.25858.
Wiemels JL, Wrensch M, Sison JD, Zhou M, Bondy M, Calvocoressi L, et al. Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls. Int J Cancer. 2011 Oct 15;129(8):1932–9.
Wiemels, Joseph L., et al. “Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls.Int J Cancer, vol. 129, no. 8, Oct. 2011, pp. 1932–39. Pubmed, doi:10.1002/ijc.25858.
Wiemels JL, Wrensch M, Sison JD, Zhou M, Bondy M, Calvocoressi L, Black PM, Yu H, Schildkraut JM, Claus EB. Reduced allergy and immunoglobulin E among adults with intracranial meningioma compared to controls. Int J Cancer. 2011 Oct 15;129(8):1932–1939.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

October 15, 2011

Volume

129

Issue

8

Start / End Page

1932 / 1939

Location

United States

Related Subject Headings

  • Oncology & Carcinogenesis
  • Middle Aged
  • Meningioma
  • Meningeal Neoplasms
  • Male
  • Immunoglobulin E
  • Hypersensitivity
  • Humans
  • Female
  • Case-Control Studies