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Parathyroid lesions: characterization with dual-phase arterial and venous enhanced CT of the neck.

Publication ,  Journal Article
Gafton, AR; Glastonbury, CM; Eastwood, JD; Hoang, JK
Published in: AJNR Am J Neuroradiol
May 2012

This clinical report describes the enhancement characteristics of hypersecreting parathyroid lesions on dual-phase neck CT. We retrospectively analyzed the enhancement characteristics of 5 pathologically confirmed PTH-secreting lesions on dual-phase CT examinations. Attenuation values were measured for PTH-secreting lesions, vascular structures (CCA and IJV), and soft tissue structures (thyroid gland, jugulodigastric lymph node, and submandibular gland). From the attenuation values, "relative enhancement washout percentage" and "tissue-vascular ratio" were calculated and compared. All lesions decreased in attenuation from arterial to venous phase, while the mean attenuation values of other soft tissue structures increased. A high relative enhancement washout percentage was correlated with parathyroid lesions (P < .006). The tissue-CCA ratio and tissue-IJV ratio for PTH-secreting lesions in the arterial phase were statistically significantly higher compared with soft tissue structures (P < .05). If these results are validated in future larger studies, noncontrast and delayed venous phases of 4D-CT could be eliminated to markedly reduce radiation exposure.

Duke Scholars

Published In

AJNR Am J Neuroradiol

DOI

EISSN

1936-959X

Publication Date

May 2012

Volume

33

Issue

5

Start / End Page

949 / 952

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiography
  • Parathyroid Neoplasms
  • Nuclear Medicine & Medical Imaging
  • Neck
  • Middle Aged
  • Metabolic Clearance Rate
  • Injections, Intravenous
  • Injections, Intra-Arterial
 

Citation

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MLA
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Gafton, A. R., Glastonbury, C. M., Eastwood, J. D., & Hoang, J. K. (2012). Parathyroid lesions: characterization with dual-phase arterial and venous enhanced CT of the neck. AJNR Am J Neuroradiol, 33(5), 949–952. https://doi.org/10.3174/ajnr.A2885
Gafton, A. R., C. M. Glastonbury, J. D. Eastwood, and J. K. Hoang. “Parathyroid lesions: characterization with dual-phase arterial and venous enhanced CT of the neck.AJNR Am J Neuroradiol 33, no. 5 (May 2012): 949–52. https://doi.org/10.3174/ajnr.A2885.
Gafton AR, Glastonbury CM, Eastwood JD, Hoang JK. Parathyroid lesions: characterization with dual-phase arterial and venous enhanced CT of the neck. AJNR Am J Neuroradiol. 2012 May;33(5):949–52.
Gafton, A. R., et al. “Parathyroid lesions: characterization with dual-phase arterial and venous enhanced CT of the neck.AJNR Am J Neuroradiol, vol. 33, no. 5, May 2012, pp. 949–52. Pubmed, doi:10.3174/ajnr.A2885.
Gafton AR, Glastonbury CM, Eastwood JD, Hoang JK. Parathyroid lesions: characterization with dual-phase arterial and venous enhanced CT of the neck. AJNR Am J Neuroradiol. 2012 May;33(5):949–952.

Published In

AJNR Am J Neuroradiol

DOI

EISSN

1936-959X

Publication Date

May 2012

Volume

33

Issue

5

Start / End Page

949 / 952

Location

United States

Related Subject Headings

  • Sensitivity and Specificity
  • Reproducibility of Results
  • Radiography
  • Parathyroid Neoplasms
  • Nuclear Medicine & Medical Imaging
  • Neck
  • Middle Aged
  • Metabolic Clearance Rate
  • Injections, Intravenous
  • Injections, Intra-Arterial