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Effective spread and timecourse of neural inactivation caused by lidocaine injection in monkey cerebral cortex.

Publication ,  Journal Article
Tehovnik, EJ; Sommer, MA
Published in: Journal of neuroscience methods
June 1997

We studied the effective spread of lidocaine to inactivate neural tissue in the frontal cortex of the rhesus monkey. Injections of 2% lidocaine at 4 microl/min were made while units were recorded 1 or 2 mm away. To inactivate units 1 mm away from the injection site 100% of the time, 7 microl of lidocaine had to be injected. To inactivate units 2 mm away from the injection site 100% of the time, 30 microl of lidocaine were required. Units were maximally inactivated around 8 min after the start of a lidocaine injection, and they gradually recovered, regaining most of their initial activity by around 30 min after the start of an injection. The volume of lidocaine required to inactivate neurons > 90% of the time could be estimated by the spherical volume equation, V = 4/3 pi (r)3. To prolong the inactivation, a slower infusion of lidocaine subsequent to an initial bolus was effective. Saline control injections had no effect. These results allow both a prediction of the timecourse of neural inactivation and an estimate of the spread of neural inactivation following injection of lidocaine into the monkey cerebral cortex.

Duke Scholars

Published In

Journal of neuroscience methods

DOI

EISSN

1872-678X

ISSN

0165-0270

Publication Date

June 1997

Volume

74

Issue

1

Start / End Page

17 / 26

Related Subject Headings

  • Time Factors
  • Probability
  • Neurons
  • Neurology & Neurosurgery
  • Microinjections
  • Macaca mulatta
  • Lidocaine
  • Infusions, Parenteral
  • Cerebral Cortex
  • Animals
 

Citation

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ICMJE
MLA
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Tehovnik, E. J., & Sommer, M. A. (1997). Effective spread and timecourse of neural inactivation caused by lidocaine injection in monkey cerebral cortex. Journal of Neuroscience Methods, 74(1), 17–26. https://doi.org/10.1016/s0165-0270(97)02229-2
Tehovnik, E. J., and M. A. Sommer. “Effective spread and timecourse of neural inactivation caused by lidocaine injection in monkey cerebral cortex.Journal of Neuroscience Methods 74, no. 1 (June 1997): 17–26. https://doi.org/10.1016/s0165-0270(97)02229-2.
Tehovnik EJ, Sommer MA. Effective spread and timecourse of neural inactivation caused by lidocaine injection in monkey cerebral cortex. Journal of neuroscience methods. 1997 Jun;74(1):17–26.
Tehovnik, E. J., and M. A. Sommer. “Effective spread and timecourse of neural inactivation caused by lidocaine injection in monkey cerebral cortex.Journal of Neuroscience Methods, vol. 74, no. 1, June 1997, pp. 17–26. Epmc, doi:10.1016/s0165-0270(97)02229-2.
Tehovnik EJ, Sommer MA. Effective spread and timecourse of neural inactivation caused by lidocaine injection in monkey cerebral cortex. Journal of neuroscience methods. 1997 Jun;74(1):17–26.
Journal cover image

Published In

Journal of neuroscience methods

DOI

EISSN

1872-678X

ISSN

0165-0270

Publication Date

June 1997

Volume

74

Issue

1

Start / End Page

17 / 26

Related Subject Headings

  • Time Factors
  • Probability
  • Neurons
  • Neurology & Neurosurgery
  • Microinjections
  • Macaca mulatta
  • Lidocaine
  • Infusions, Parenteral
  • Cerebral Cortex
  • Animals