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Respiration during acute hypoxia: angiotensin- and vasopressin-receptor blocks.

Publication ,  Journal Article
Overgaard, CB; Walker, JK; Jennings, DB
Published in: Journal of applied physiology (Bethesda, Md. : 1985)
March 1996

In normoxic conscious dogs, increased angiotensin II (ANG II), or activation (disinhibition) of the renin-angiotensin system by vasopressin (AVP) V1-receptor block, increases ventilation and decreases arterial PCO2. Both hormones can be increased during hypoxia and might modulate ventilatory drive. Six conscious dogs were studied before and during hypocapnic, isocapnic, and hypercapnic hypoxia. To study potential hormonal effects during hypocapnic hypoxia, experiment 1 included three protocols in which 12.8% O2 was breathed for 60 min: protocol 1, control studies without block; protocol 2, AVP V1 receptors were blocked at the onset of hypoxia; and protocol 3, ANG II receptors were blocked 20 min before hypoxia. To study potential effects of acid-base changes during acute hypoxia, experiment 2 included two protocols (with and without AVP V1-receptor block). A 40-min period of hypocapnic hypoxia was followed by two successive 20-min periods with hypoxia maintained but inspired CO2 progressively increased. Neither hormonal block affected respiration during the hypoxic conditions. Unlike normoxia in conscious dogs, during acute hypoxia, respiratory control by ANG II is not modulated by AVP and acid-base effects on receptors do not account for this difference.

Duke Scholars

Published In

Journal of applied physiology (Bethesda, Md. : 1985)

DOI

EISSN

1522-1601

ISSN

8750-7587

Publication Date

March 1996

Volume

80

Issue

3

Start / End Page

810 / 817

Related Subject Headings

  • Time Factors
  • Respiration
  • Receptors, Vasopressin
  • Receptors, Angiotensin
  • Physiology
  • Male
  • Hypoxia
  • Hypocapnia
  • Dogs
  • Animals
 

Citation

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Overgaard, C. B., Walker, J. K., & Jennings, D. B. (1996). Respiration during acute hypoxia: angiotensin- and vasopressin-receptor blocks. Journal of Applied Physiology (Bethesda, Md. : 1985), 80(3), 810–817. https://doi.org/10.1152/jappl.1996.80.3.810
Overgaard, C. B., J. K. Walker, and D. B. Jennings. “Respiration during acute hypoxia: angiotensin- and vasopressin-receptor blocks.Journal of Applied Physiology (Bethesda, Md. : 1985) 80, no. 3 (March 1996): 810–17. https://doi.org/10.1152/jappl.1996.80.3.810.
Overgaard CB, Walker JK, Jennings DB. Respiration during acute hypoxia: angiotensin- and vasopressin-receptor blocks. Journal of applied physiology (Bethesda, Md : 1985). 1996 Mar;80(3):810–7.
Overgaard, C. B., et al. “Respiration during acute hypoxia: angiotensin- and vasopressin-receptor blocks.Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 80, no. 3, Mar. 1996, pp. 810–17. Epmc, doi:10.1152/jappl.1996.80.3.810.
Overgaard CB, Walker JK, Jennings DB. Respiration during acute hypoxia: angiotensin- and vasopressin-receptor blocks. Journal of applied physiology (Bethesda, Md : 1985). 1996 Mar;80(3):810–817.

Published In

Journal of applied physiology (Bethesda, Md. : 1985)

DOI

EISSN

1522-1601

ISSN

8750-7587

Publication Date

March 1996

Volume

80

Issue

3

Start / End Page

810 / 817

Related Subject Headings

  • Time Factors
  • Respiration
  • Receptors, Vasopressin
  • Receptors, Angiotensin
  • Physiology
  • Male
  • Hypoxia
  • Hypocapnia
  • Dogs
  • Animals