HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44.

Published

Journal Article

Acute HIV-1 infection results in dysregulated immunity, which contributes to poor control of viral infection. DCs are key regulators of both adaptive and innate immune responses needed for controlling HIV-1, and we surmised that factors elicited during acute HIV-1 infection might impede DC function. We derived immature DCs from healthy donor peripheral blood monocytes and treated them with plasma from uninfected control donors and donors with acute HIV-1 infections. We found that the plasma from patients with HIV specifically inhibited DC function. This suppression was mediated by elevated apoptotic microparticles derived from dying cells during acute HIV-1 infection. Apoptotic microparticles bound to and inhibited DCs through the hyaluronate receptor CD44. These data suggest that targeting this CD44-mediated inhibition by apoptotic microparticles could be a novel strategy to potentiate DC activation of HIV-specific immunity.

Full Text

Duke Authors

Cited Authors

  • Frleta, D; Ochoa, CE; Kramer, HB; Khan, SA; Stacey, AR; Borrow, P; Kessler, BM; Haynes, BF; Bhardwaj, N

Published Date

  • December 2012

Published In

Volume / Issue

  • 122 / 12

Start / End Page

  • 4685 - 4697

PubMed ID

  • 23160198

Pubmed Central ID

  • 23160198

Electronic International Standard Serial Number (EISSN)

  • 1558-8238

Digital Object Identifier (DOI)

  • 10.1172/JCI64439

Language

  • eng

Conference Location

  • United States