In an attempt to reduce the lengthy process of translating scientific findings into clinical practice, the United States and several European governments are making substantial investments in health information technology, comparative effectiveness research, and increased access to quality health care. New technologies--genomics in particular--are expected to usher in more cost-effective personalized health care. Academic medical centers can play a central role in this transformation through the development of rapid learning environments, evidence generation, implementation research, and education of health professionals and the public.