Platelet function monitoring in patients with coronary artery disease.
Journal Article (Journal Article;Review)
Studies focused on patient responsiveness to antiplatelet therapies, particularly aspirin and clopidogrel, have increased in recent years. However, the relations of in vivo platelet function and adverse clinical events to results of ex vivo platelet function tests remain largely unknown. This article describes current methods of measuring platelet function in various clinical and research situations and their advantages and disadvantages, reviews evidence for antiplatelet response variability and resistance, discusses the potential pitfalls of monitoring platelet function, and demonstrates emerging data supporting the positive clinical and treatment implications of platelet function testing.
Full Text
Duke Authors
Cited Authors
- Gurbel, PA; Becker, RC; Mann, KG; Steinhubl, SR; Michelson, AD
Published Date
- November 6, 2007
Published In
Volume / Issue
- 50 / 19
Start / End Page
- 1822 - 1834
PubMed ID
- 17980247
Electronic International Standard Serial Number (EISSN)
- 1558-3597
Digital Object Identifier (DOI)
- 10.1016/j.jacc.2007.07.051
Language
- eng
Conference Location
- United States