Cell cycle progression: new therapeutic target for vascular proliferative disease.

Journal Article (Journal Article;Review)

Entry into and progression of vascular cells through the cell cycle is considered a key event in vascular proliferative diseases. Multiple growth factors and cytokines have been found to regulate vascular cell proliferation. However, the machinery regulating cell cycle represents the "final common pathway" of these signaling cascades and thus provides an attractive therapeutic target for the prevention of vascular proliferative diseases. This review focuses on the current understanding of the regulation of the cell cycle machinery especially as it relates to vascular cell biology and the feasibility of targeting cell cycle for the prevention of restenosis after balloon angioplasty and bypass vein graft disease.

Full Text

Duke Authors

Cited Authors

  • Braun-Dullaeus, RC; Mann, MJ; Dzau, VJ

Published Date

  • July 7, 1998

Published In

Volume / Issue

  • 98 / 1

Start / End Page

  • 82 - 89

PubMed ID

  • 9665064

International Standard Serial Number (ISSN)

  • 0009-7322

Digital Object Identifier (DOI)

  • 10.1161/01.cir.98.1.82


  • eng

Conference Location

  • United States