Autocrine and paracrine mechanisms in the pathophysiology of heart failure.

Journal Article (Journal Article;Review)

At the cellular and molecular level the transition to heart failure is a complex process that involves structural adaptation, not only of the heart, but of peripheral vasculature and renal tissues as well. Recent studies have suggested that autocrine, paracrine, and circulating biologically active mediators activate events that result in the concerted failure of adaptive mechanisms and the ultimate depression of cardiac myocyte function. Greater understanding of these local mechanisms in the future may lead to drug therapies that can selectively block these mechanisms and prevent the progression from compensation to overt heart failure.

Full Text

Duke Authors

Cited Authors

  • Dzau, VJ

Published Date

  • October 8, 1992

Published In

Volume / Issue

  • 70 / 10

Start / End Page

  • 4C - 11C

PubMed ID

  • 1357950

International Standard Serial Number (ISSN)

  • 0002-9149

Digital Object Identifier (DOI)

  • 10.1016/0002-9149(92)91352-5


  • eng

Conference Location

  • United States