Angiotensin converting enzyme inhibitors and the cardiovascular system.


Journal Article (Review)

OBJECTIVE: To show that angiotensin converting enzyme (ACE) inhibitors benefit the cardiovascular system to a greater extent than other antihypertensive agents. DATA EXTRACTION: An extensive literature search has shown that ACE inhibitors can induce regression of left ventricular hypertrophy, which may improve systolic and/or diastolic function in the left ventricle; increase in arterial compliance; and improve clinical signs of congestive heart failure and reduce mortality in patients with severe heart failure. In addition, ACE inhibitors have either a neutral or a beneficial effect on blood lipids and lipoproteins. These agents also have potential anti-ischaemic and anti-arrhythmic activity but do not depress resting cardiac function. CONCLUSION: ACE inhibitors are uniquely valuable first-line antihypertensive agents, especially in patients with cardiovascular risk.

Full Text

Duke Authors

Cited Authors

  • Dzau, VJ

Published Date

  • June 1992

Published In

Volume / Issue

  • 10 / 3

Start / End Page

  • S3 - 10

PubMed ID

  • 1386105

Pubmed Central ID

  • 1386105

International Standard Serial Number (ISSN)

  • 0952-1178


  • eng

Conference Location

  • England