Renin promoter SV40 T-antigen transgenic mouse. A model of primary renal vascular hyperplasia.

Published

Journal Article

Transgenic mice containing a ren-2 promoter T-antigen fusion construct (TAG+) develop renal vascular hypertrophy and hyperplasia associated with markedly suppressed renal renin mRNA, renal renin content, and plasma renin concentration. These animals are normotensive. In the present study, the renal and cardiovascular systems are characterized, revealing some surprising findings. Not only are the TAG+ mice normotensive in the face of pronounced renal pathology but also in the presence of an increase in plasma volume. These data raise interesting questions about blood pressure physiology and renal function of the TAG+ mice. Blood nitrogen urea of the TAG+ animal was markedly elevated and plasma creatinine level was in the normal range, indicating prerenal azotemia without renal failure. These findings are consistent with impaired renal perfusion with secondary volume expansion probably as the result of vascular hyperplasia. These transgenic animals provide a unique genetic model for studying the physiology of primarily renal vascular hyperplasia as well as blood pressure control in a low renin state.

Full Text

Duke Authors

Cited Authors

  • Jacob, HJ; Sigmund, CD; Shockley, TR; Gross, KW; Dzau, VJ

Published Date

  • June 1991

Published In

Volume / Issue

  • 17 / 6 Pt 2

Start / End Page

  • 1167 - 1162

PubMed ID

  • 2045162

Pubmed Central ID

  • 2045162

International Standard Serial Number (ISSN)

  • 0194-911X

Digital Object Identifier (DOI)

  • 10.1161/01.hyp.17.6.1167

Language

  • eng

Conference Location

  • United States