Vascular renin-angiotensin system in hypertension. New insights into the mechanism of action of angiotensin converting enzyme inhibitors.
Publication
, Journal Article
Dzau, VJ
Published in: Am J Med
April 15, 1988
Evidence is accumulating that demonstrates the presence of local renin-angiotensin systems, in addition to the established circulating renin-angiotensin system. Renin-like substances, immunoreactive angiotensins, and angiotensin II receptors have been identified throughout the vasculature. Local tissue concentrations of angiotensin converting enzyme (ACE) inhibitors, rather than serum concentrations, may be more important in determining the magnitude and duration of the long-term cardiac and vascular response to this group of drugs. Certain structural and chemical properties of the ACE inhibitors may provide unique effects at various tissue sites.
Duke Scholars
Published In
Am J Med
DOI
ISSN
0002-9343
Publication Date
April 15, 1988
Volume
84
Issue
4A
Start / End Page
4 / 8
Location
United States
Related Subject Headings
- Renin-Angiotensin System
- Hypertension
- Humans
- General & Internal Medicine
- Blood Vessels
- Blood Pressure
- Animals
- Angiotensin-Converting Enzyme Inhibitors
- 42 Health sciences
- 32 Biomedical and clinical sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Dzau, V. J. (1988). Vascular renin-angiotensin system in hypertension. New insights into the mechanism of action of angiotensin converting enzyme inhibitors. Am J Med, 84(4A), 4–8. https://doi.org/10.1016/0002-9343(88)90463-9
Dzau, V. J. “Vascular renin-angiotensin system in hypertension. New insights into the mechanism of action of angiotensin converting enzyme inhibitors.” Am J Med 84, no. 4A (April 15, 1988): 4–8. https://doi.org/10.1016/0002-9343(88)90463-9.
Dzau VJ. Vascular renin-angiotensin system in hypertension. New insights into the mechanism of action of angiotensin converting enzyme inhibitors. Am J Med. 1988 Apr 15;84(4A):4–8.
Dzau, V. J. “Vascular renin-angiotensin system in hypertension. New insights into the mechanism of action of angiotensin converting enzyme inhibitors.” Am J Med, vol. 84, no. 4A, Apr. 1988, pp. 4–8. Pubmed, doi:10.1016/0002-9343(88)90463-9.
Dzau VJ. Vascular renin-angiotensin system in hypertension. New insights into the mechanism of action of angiotensin converting enzyme inhibitors. Am J Med. 1988 Apr 15;84(4A):4–8.
Published In
Am J Med
DOI
ISSN
0002-9343
Publication Date
April 15, 1988
Volume
84
Issue
4A
Start / End Page
4 / 8
Location
United States
Related Subject Headings
- Renin-Angiotensin System
- Hypertension
- Humans
- General & Internal Medicine
- Blood Vessels
- Blood Pressure
- Animals
- Angiotensin-Converting Enzyme Inhibitors
- 42 Health sciences
- 32 Biomedical and clinical sciences