Vascular renin-angiotensin system in hypertension. New insights into the mechanism of action of angiotensin converting enzyme inhibitors.

Journal Article (Journal Article)

Evidence is accumulating that demonstrates the presence of local renin-angiotensin systems, in addition to the established circulating renin-angiotensin system. Renin-like substances, immunoreactive angiotensins, and angiotensin II receptors have been identified throughout the vasculature. Local tissue concentrations of angiotensin converting enzyme (ACE) inhibitors, rather than serum concentrations, may be more important in determining the magnitude and duration of the long-term cardiac and vascular response to this group of drugs. Certain structural and chemical properties of the ACE inhibitors may provide unique effects at various tissue sites.

Full Text

Duke Authors

Cited Authors

  • Dzau, VJ

Published Date

  • April 15, 1988

Published In

Volume / Issue

  • 84 / 4A

Start / End Page

  • 4 - 8

PubMed ID

  • 3218657

Pubmed Central ID

  • 3218657

International Standard Serial Number (ISSN)

  • 0002-9343

Digital Object Identifier (DOI)

  • 10.1016/0002-9343(88)90463-9


  • eng

Conference Location

  • United States