Pathophysiology of experimental renovascular hypertension.
Publication
, Journal Article
Nabel, EG; Gibbons, GH; Dzau, VJ
Published in: Am J Kidney Dis
April 1985
The genesis of renovascular hypertension follows a continuum from an acute to a chronic phase. Reduction in renal perfusion initiates renin release and angiotensin-mediated systemic vasoconstriction. Aldosterone secretion, sodium and water retention, and expansion of the extracellular volume ensue. Sustained hypertension is further maintained by interacting physiologic mechanisms including increased angiotensin II sensitivity, vasopressin, ouabain-like substance, the sympathetic nervous system, CNS mechanisms, autoregulation, and structural changes.
Duke Scholars
Published In
Am J Kidney Dis
DOI
ISSN
0272-6386
Publication Date
April 1985
Volume
5
Issue
4
Start / End Page
A111 / A119
Location
United States
Related Subject Headings
- Vasopressins
- Vasoconstriction
- Urology & Nephrology
- Sympathetic Nervous System
- Renin-Angiotensin System
- Rats
- Perfusion
- Ouabain
- Kidney
- Hypertension, Renovascular
Citation
APA
Chicago
ICMJE
MLA
NLM
Nabel, E. G., Gibbons, G. H., & Dzau, V. J. (1985). Pathophysiology of experimental renovascular hypertension. Am J Kidney Dis, 5(4), A111–A119. https://doi.org/10.1016/s0272-6386(85)80073-1
Nabel, E. G., G. H. Gibbons, and V. J. Dzau. “Pathophysiology of experimental renovascular hypertension.” Am J Kidney Dis 5, no. 4 (April 1985): A111–19. https://doi.org/10.1016/s0272-6386(85)80073-1.
Nabel EG, Gibbons GH, Dzau VJ. Pathophysiology of experimental renovascular hypertension. Am J Kidney Dis. 1985 Apr;5(4):A111–9.
Nabel, E. G., et al. “Pathophysiology of experimental renovascular hypertension.” Am J Kidney Dis, vol. 5, no. 4, Apr. 1985, pp. A111–19. Pubmed, doi:10.1016/s0272-6386(85)80073-1.
Nabel EG, Gibbons GH, Dzau VJ. Pathophysiology of experimental renovascular hypertension. Am J Kidney Dis. 1985 Apr;5(4):A111–A119.
Published In
Am J Kidney Dis
DOI
ISSN
0272-6386
Publication Date
April 1985
Volume
5
Issue
4
Start / End Page
A111 / A119
Location
United States
Related Subject Headings
- Vasopressins
- Vasoconstriction
- Urology & Nephrology
- Sympathetic Nervous System
- Renin-Angiotensin System
- Rats
- Perfusion
- Ouabain
- Kidney
- Hypertension, Renovascular