Renin-specific antibody for study of cardiovascular homeostasis.
Publication
, Journal Article
Dzau, VJ; Kopelman, RI; Barger, AC; Haber, E
Published in: Science
March 7, 1980
Antiserum specific for purified canine renal renin was used to inhibit this enzyme in trained, conscious dogs. The antiserum did not affect blood pressure in sodium-replete dogs but decreased plasma renin activity and blood pressure in sodium-depleted animals. The antiserum also reduced blood pressure to control levels concomitant with suppression of plasma renin activity in uninephrectomized dogs with acute renovascular hypertension. These observations establish the role of the renin-angiotensin system in the maintenance of blood pressure in the sodium-depleted state as well as in the initiation of renovascular hypertension.
Duke Scholars
Published In
Science
DOI
ISSN
0036-8075
Publication Date
March 7, 1980
Volume
207
Issue
4435
Start / End Page
1091 / 1093
Location
United States
Related Subject Headings
- Vascular Resistance
- Renin
- Kidney
- Immunologic Techniques
- Hypertension, Renovascular
- Hypertension, Renal
- Homeostasis
- General Science & Technology
- Dogs
- Diet, Sodium-Restricted
Citation
APA
Chicago
ICMJE
MLA
NLM
Dzau, V. J., Kopelman, R. I., Barger, A. C., & Haber, E. (1980). Renin-specific antibody for study of cardiovascular homeostasis. Science, 207(4435), 1091–1093. https://doi.org/10.1126/science.6986653
Dzau, V. J., R. I. Kopelman, A. C. Barger, and E. Haber. “Renin-specific antibody for study of cardiovascular homeostasis.” Science 207, no. 4435 (March 7, 1980): 1091–93. https://doi.org/10.1126/science.6986653.
Dzau VJ, Kopelman RI, Barger AC, Haber E. Renin-specific antibody for study of cardiovascular homeostasis. Science. 1980 Mar 7;207(4435):1091–3.
Dzau, V. J., et al. “Renin-specific antibody for study of cardiovascular homeostasis.” Science, vol. 207, no. 4435, Mar. 1980, pp. 1091–93. Pubmed, doi:10.1126/science.6986653.
Dzau VJ, Kopelman RI, Barger AC, Haber E. Renin-specific antibody for study of cardiovascular homeostasis. Science. 1980 Mar 7;207(4435):1091–1093.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
March 7, 1980
Volume
207
Issue
4435
Start / End Page
1091 / 1093
Location
United States
Related Subject Headings
- Vascular Resistance
- Renin
- Kidney
- Immunologic Techniques
- Hypertension, Renovascular
- Hypertension, Renal
- Homeostasis
- General Science & Technology
- Dogs
- Diet, Sodium-Restricted