Renin-specific antibody for study of cardiovascular homeostasis.

Journal Article (Journal Article)

Antiserum specific for purified canine renal renin was used to inhibit this enzyme in trained, conscious dogs. The antiserum did not affect blood pressure in sodium-replete dogs but decreased plasma renin activity and blood pressure in sodium-depleted animals. The antiserum also reduced blood pressure to control levels concomitant with suppression of plasma renin activity in uninephrectomized dogs with acute renovascular hypertension. These observations establish the role of the renin-angiotensin system in the maintenance of blood pressure in the sodium-depleted state as well as in the initiation of renovascular hypertension.

Full Text

Duke Authors

Cited Authors

  • Dzau, VJ; Kopelman, RI; Barger, AC; Haber, E

Published Date

  • March 7, 1980

Published In

Volume / Issue

  • 207 / 4435

Start / End Page

  • 1091 - 1093

PubMed ID

  • 6986653

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.6986653


  • eng

Conference Location

  • United States