Induction of apoptosis by tumor suppressor genes and oncogenes.

Journal Article (Review)

The p53 tumor suppressor gene product, and the bcr-abl, bcl-2, and c-myc gene products all appear to influence the susceptibility of cells to apoptosis. In addition to the role p53 protein plays in mediating a cell cycle arrest in G1 following DNA damage, p53 also performs functions critical for removal of damaged cells by initiating apoptosis in certain physiological situations. Cells which express deregulated c-myc are sensitized to apoptosis following various growth suppressing stimuli and these observations have provided new insights into how apoptosis-suppressing genes such as mutant p53, bcl-2 and bcr-abl may cooperate during transformation and how they might influence the sensitivity of cells to radiation and chemotherapy.

Full Text

Duke Authors

Cited Authors

  • Canman, CE; Kastan, MB

Published Date

  • February 1995

Published In

Volume / Issue

  • 6 / 1

Start / End Page

  • 17 - 25

PubMed ID

  • 7548837

Pubmed Central ID

  • 7548837

Electronic International Standard Serial Number (EISSN)

  • 1096-3650

International Standard Serial Number (ISSN)

  • 1044-579X

Digital Object Identifier (DOI)

  • 10.1006/scbi.1995.0003


  • eng