Michael Barry Kastan | Scholars@Duke

Michael Barry Kastan
William and Jane Shingleton Professor of Pharmacology and Cancer Biology

Current Appointments & Affiliations

William and Jane Shingleton Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2012
Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2012
Director of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2011
Professor of Pediatrics, Pediatrics, Clinical Science Departments 2012
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2010
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2011
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2017

Contact Information

DUMC Box 3917, 10 Bryan Searle Drive, Rm 422, Durham, NC 27710
DUMC Box 3917, 10 Bryan Searle Drive, Rm 422, Durham, NC 27710
michael.kastan@duke.edu (919) 684-3052

Background
Education, Training, & Certifications
- M.D., Washington University in St. Louis 1984
- Ph.D., Washington University in St. Louis 1984
Duke Appointment History
- Consulting Professor in Pediatrics, Pediatrics, Hematology-Oncology, Pediatrics 2011 - 2012
- Consulting Professor of Pharmacology and Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2011 - 2012
Recognition
In the News
- APR 18, 2017 Duke Health News
  
  Duke Health and WakeMed Agree to Collaborate on Cancer Care in Wake County
- APR 4, 2017 Duke Health News
  
  New Insight Illuminates How Cells Respond to Stress
- JUN 29, 2016 WNCN
  
  Duke Cancer Institute helps to host federal cancer summit meeting in Chapel Hill
- MAY 4, 2016
  
  Duke Cancer Leader Michael Kastan Is Named to National Academy of Sciences
- MAR 4, 2016 The News & Observer
  
  Duke doctors, NCSU vets team up against cancer
- FEB 12, 2016 The News & Observer
  
  Editorial: At Duke, Biden launches a ‘moonshot’ to beat cancer
- FEB 10, 2016
  
  Vice President Visits to Discuss Cancer 'Moonshot'
- JAN 29, 2016 WRAL
  
  NC State, Duke partnering to research cancer in dogs, help humans
- JAN 27, 2016
  
  Duke Cancer Institute Joins National Endorsement of HPV Vaccination
- OCT 22, 2015 The New York Times
  
  Dr. Michael Kastan comments: Learning from dogs with cancer
- MAY 13, 2014 Triangle Business Journal
  
  UNC-Duke cancer centers form partnership to advance early stage research
- MAY 2, 2014
  
  Duke Cancer Institute Teams with UNC, WUSTL to Speed Drug Development
- APR 23, 2014
  
  2014 Election of New Members of the American Academy of Arts and Sciences
- SEP 30, 2013
  
  New Insights into DNA Repair Process May Spur Better Cancer Therapies
Awards & Honors
Research
Selected Grants
- The Role of USP22 in Prostate Cancer Development and Progression awarded by National Institutes of Health 2019 - 2023
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Evaluation of kinase inhibitors awarded by XRAD THERAPEUTICS, INC. 2016 - 2021
- The role of ATM in Metabolic Stress Responses awarded by National Institutes of Health 2011 - 2021
- The role of Mtss1 in Hedgehog-mediated intestinal cancer stem cell function awarded by National Institutes of Health 2015 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- Administrative Supplements for P30 CCSG awarded by National Institutes of Health 2015 - 2019
- Collaborative Success: Expanding Options for Patients with Melanoma awarded by National Institutes of Health 1997 - 2019
- Duke Cancer Institute Application for Administrative Supplement for the P30 Cancer Center Support Grant to Develop Tobacco Cessation Treatment Capacity and Infrastructure for Cancer Patients awarded by National Institutes of Health 1997 - 2019
- Cancer Center Support Grant awarded by National Institutes of Health 1976 - 2019
- Kastan Gray Foundation Project awarded by Gray Foundation 2017 - 2019
- C30 Canine Pilot Research awarded by V Foundation for Cancer Research 2016 - 2019
- Duke University Program in Environmental Health awarded by National Institute of Environmental Health Sciences 2013 - 2019
- Cellular Stress Response Signaling Pathways awarded by National Institutes of Health 1992 - 2019
- Copy Number Alterations in Low Mutation Cancer awarded by National Institutes of Health 2018 - 2019
- Identification of Therapeutic Interventions in Ataxia-Telangiectasia Using a Novel Model of Metabolic Stress awarded by University of Pennsylvania 2017 - 2018
- Center for Molecular & Cellular Studies of Ped Disease awarded by National Institutes of Health 2003 - 2018
- Using bacterial CRISPR/Cas endonucleases to selectively eliminate HPV-transformed cells in vivo awarded by National Institutes of Health 2015 - 2017
- Development and Validation of Novel Therapeutic Targets in Anal Cancer awarded by The Farrah Fawcett Foundation 2015 - 2016
- Metabolic Sensing and Stress Response Deficit in Ataxia Telangiectasia awarded by A-T Children's Project 2014 - 2016
- Chromatin Modulation Associated with DNA Breakage and Repair in Human Cells awarded by National Institutes of Health 2011 - 2016
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- Evaluating GSK2126458 with radiation therapy in pre-clinical models awarded by GlaxoSmithKline 2013 - 2015
- Screening for ATM/DNA-PK inhibitors awarded by GlaxoSmithKline 2014 - 2015
Publications & Artistic Works
Selected Publications
- Books
  - Niederhuber, JE, Armitage, JO, Doroshow, JH, Kastan, MB, and Tepper, JE. Abeloff's Clinical Oncology: Fifth Edition. October 22, 2013.
  - Niederhuber, JE, Armitage, JO, Doroshow, JH, Kastan, MB, and Tepper, JE. Preface. October 22, 2013. Full Text
- Academic Articles
  - Chen, J, and Kastan, MB. "A novel DNA damage-induced alternative splicing pathway that regulates p53 and cellular senescence markers." Oncoscience 4, no. 9-10 (September 2017): 122-123. Full Text Open Access Copy
  - Chen, J, Crutchley, J, Zhang, D, Owzar, K, and Kastan, MB. "Identification of a DNA Damage-Induced Alternative Splicing Pathway That Regulates p53 and Cellular Senescence Markers." Cancer discovery 7, no. 7 (July 2017): 766-781. Full Text
  - Liu, X, Li, F, Huang, Q, Zhang, Z, Zhou, L, Deng, Y, Zhou, M, Fleenor, DE, Wang, H, Kastan, MB, and Li, C-Y. "Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells." Cell research 27, no. 6 (June 2017): 764-783. Full Text
  - Kastan, MB. "Commentary on "Participation of p53 Protein in the Cellular Response to DNA Damage"." Cancer research 76, no. 13 (July 2016): 3663-3665. Full Text
  - LeBlanc, AK, Breen, M, Choyke, P, Dewhirst, M, Fan, TM, Gustafson, DL, Helman, LJ, Kastan, MB, Knapp, DW, Levin, WJ, London, C, Mason, N, Mazcko, C, Olson, PN, Page, R, Teicher, BA, Thamm, DH, Trent, JM, Vail, DM, and Khanna, C. "Perspectives from man's best friend: National Academy of Medicine's Workshop on Comparative Oncology." Science Translational Medicine 8, no. 324 (February 2016): 324ps5-null. (Review) Full Text
  - Min, J, Guo, K, Suryadevara, PK, Zhu, F, Holbrook, G, Chen, Y, Feau, C, Young, BM, Lemoff, A, Connelly, MC, Kastan, MB, and Guy, RK. "Optimization of a Novel Series of Ataxia-Telangiectasia Mutated Kinase Inhibitors as Potential Radiosensitizing Agents." Journal of Medicinal Chemistry 59, no. 2 (January 12, 2016): 559-577. Full Text
  - Bakkenist, CJ, and Kastan, MB. "Chromatin perturbations during the DNA damage response in higher eukaryotes." DNA repair 36 (December 2015): 8-12. (Review) Full Text
  - Zhang, J, Tripathi, DN, Jing, J, Alexander, A, Kim, J, Powell, RT, Dere, R, Tait-Mulder, J, Lee, J-H, Paull, TT, Pandita, RK, Charaka, VK, Pandita, TK, Kastan, MB, and Walker, CL. "ATM functions at the peroxisome to induce pexophagy in response to ROS." Nature Cell Biology 17, no. 10 (October 2015): 1259-1269. Full Text
  - Goldstein, M, and Kastan, MB. "Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding." Cancer Research 75, no. 13 (July 2015): 2699-2707. Full Text
  - Zhang, M, Qiu, Q, Li, Z, Sachdeva, M, Min, H, Cardona, DM, DeLaney, TF, Han, T, Ma, Y, Luo, L, Ilkayeva, OR, Lui, K, Nichols, AG, Newgard, CB, Kastan, MB, Rathmell, JC, Dewhirst, MW, and Kirsch, DG. "HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism." Radiation Research 183, no. 6 (June 2015): 594-609. Full Text
  - Goldstein, M, and Kastan, MB. "The DNA damage response: implications for tumor responses to radiation and chemotherapy." Annual Review of Medicine 66 (January 2015): 129-143. (Review) Full Text
  - Henriksson, S, Rassoolzadeh, H, Hedström, E, Coucoravas, C, Julner, A, Goldstein, M, Imreh, G, Zhivotovsky, B, Kastan, MB, Helleday, T, and Farnebo, M. "The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair." Genes & Development 28, no. 24 (December 2014): 2726-2738. Full Text
  - Kastan, MB. "Abstract IA08: Ataxia-telangiectasia: Broad implications from the study of a rare disease." Cancer Research 74, no. 20 Supplement (October 15, 2014): IA08-IA08. Full Text
  - Kennedy, EM, Kornepati, AVR, Goldstein, M, Bogerd, HP, Poling, BC, Whisnant, AW, Kastan, MB, and Cullen, BR. "Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease." Journal of Virology 88, no. 20 (October 2014): 11965-11972. Full Text
  - Guo, K, Shelat, AA, Guy, RK, and Kastan, MB. "Development of a cell-based, high-throughput screening assay for ATM kinase inhibitors." Journal of Biomolecular Screening 19, no. 4 (April 2014): 538-546. Full Text
  - Wang, Q, Goldstein, M, Alexander, P, Wakeman, TP, Sun, T, Feng, J, Lou, Z, Kastan, MB, and Wang, X-F. "Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks." The Embo Journal 33, no. 8 (April 2014): 862-877. Full Text
  - Sandlund, JT, Hudson, MM, Kennedy, W, Onciu, M, and Kastan, MB. "Pilot study of modified LMB-based therapy for children with ataxia-telangiectasia and advanced stage high grade mature B-cell malignancies." Pediatric Blood & Cancer 61, no. 2 (February 2014): 360-362. Full Text
  - Guo, K, Anang, A, Shelat, R, Guy, K, and Kastan, MB. "Erratum: Development of a cell-based, high-throughput screening assay for atm kinase inhibitors (Journal of Biomolecular Screening (2014) 19:4 (538-546) DOI:10.1177/1087057113520325)." Journal of Biomolecular Screening 19, no. 10 (January 1, 2014): 1418-null. Full Text
  - Kennedy, EM, Kornepati, AVR, Goldstein, M, Bogerd, HP, Poling, BC, Whisnant, AW, Kastan, MB, and Cullen, BR. "Inactivation of the human papillomavirus E6 or E7 gene in cervical carcinoma cells by using a bacterial CRISPR/Cas RNA-guided endonuclease." Journal of Virology 88, no. 20 (January 1, 2014): 11965-11972. Full Text
  - Goldstein, M, Derheimer, FA, Tait-Mulder, J, and Kastan, MB. "Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair." Proceedings of the National Academy of Sciences of the United States of America 110, no. 42 (October 2013): 16874-16879. Full Text
  - Zhang, J, Kim, J, Alexander, A, Cai, S, Tripathi, DN, Dere, R, Tee, AR, Tait-Mulder, J, Di Nardo, A, Han, JM, Kwiatkowski, E, Dunlop, EA, Dodd, KM, Folkerth, RD, Faust, PL, Kastan, MB, Sahin, M, and Walker, CL. "A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS." Nature Cell Biology 15, no. 10 (October 2013): 1186-1196. Full Text
  - Zhang, J, Kim, J, Alexander, A, Cai, S, Tripathi, DN, Dere, R, Tee, AR, Tait-Mulder, J, Di Nardo, A, Han, JM, Kwiatkowski, E, Dunlop, EA, Dodd, KM, Folkerth, RD, Faust, PL, Kastan, MB, Sahin, M, and Walker, CL. "A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS." Nature Cell Biology 15, no. 10 (October 2013): 1186-1196. Full Text
  - Moding, EJ, Kastan, MB, and Kirsch, DG. "Strategies for optimizing the response of cancer and normal tissues to radiation." Nature Reviews. Drug Discovery 12, no. 7 (July 2013): 526-542. (Review) Full Text
  - Kastan, MB. "A message from the Editor-in-Chief." Mol Cancer Res 10, no. 12 (December 2012): 1513-. Full Text Link to Item
  - Lim, Y, Hedayati, M, Merchant, AA, Zhang, Y, Yu, H-HM, Kastan, MB, Matsui, W, and Deweese, TL. "Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation." International Journal of Radiation Oncology, Biology, Physics 84, no. 3 (November 2012): 800-806. Full Text
  - Alexander, A, Cai, SL, Kim, J, Nanez, A, Sahin, M, MacLean, KH, Inoki, K, Guan, KL, Shen, J, Person, MD, Kusewitt, D, Mills, GB, Kastan, MB, and Walker, CL. "Erratum: ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS (Proceedings of the National Academy of Sciences (2010) 107 (4153-4158) DOI: 10.1073/pnas.0913860107)." Proceedings of the National Academy of Sciences of the United States of America 109, no. 21 (May 22, 2012): 8352-null. Full Text
  - Chen, J, Guo, K, and Kastan, MB. "Interactions of nucleolin and ribosomal protein L26 (RPL26) in translational control of human p53 mRNA." The Journal of Biological Chemistry 287, no. 20 (May 2012): 16467-16476. Full Text
  - Valentin-Vega, YA, and Kastan, MB. "A new role for ATM: regulating mitochondrial function and mitophagy." Autophagy 8, no. 5 (May 2012): 840-841. Full Text
  - Razani, B, Feng, C, Coleman, T, Emanuel, R, Wen, H, Hwang, S, Ting, JP, Virgin, HW, Kastan, MB, and Semenkovich, CF. "Autophagy links inflammasomes to atherosclerotic progression." Cell Metabolism 15, no. 4 (April 2012): 534-544. Full Text
  - Valentin-Vega, YA, Maclean, KH, Tait-Mulder, J, Milasta, S, Steeves, M, Dorsey, FC, Cleveland, JL, Green, DR, and Kastan, MB. "Mitochondrial dysfunction in ataxia-telangiectasia." Blood 119, no. 6 (February 2012): 1490-1500. Full Text
  - Valentin-Vega, YA, and Kastan, MB. "A new role for ATM." AUTOPHAGY 8, no. 5 (2012): 840-841. Full Text Link to Item
  - Chen, J, Guo, K, and Kastan, MB. "Abstract 3086: Interactions of nucleolin and ribosomal protein RPL26 in the translational control of human p53 mRNA." Cancer Research 71, no. 8 Supplement (April 15, 2011): 3086-3086. Full Text
  - DeWeese, TL, Lim, Y, Hedayati, M, Merchant, A, Zhang, Y, Yu, HM, Kastan, MB, and Matsui, W. "Chloroquine Activates ATM and Improves Hematopoietic Recovery and Survival of Mice following Low Dose-rate Radiation." INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 81, no. 2 (2011): S191-S192. Full Text Link to Item
  - Chen, J, and Kastan, MB. "5'-3'-UTR interactions regulate p53 mRNA translation and provide a target for modulating p53 induction after DNA damage." Genes & Development 24, no. 19 (October 2010): 2146-2156. Full Text
  - Derheimer, FA, and Kastan, MB. "Multiple roles of ATM in monitoring and maintaining DNA integrity." Febs Letters 584, no. 17 (September 2010): 3675-3681. (Review) Full Text
  - Leung, W, Neale, G, Behm, F, Iyengar, R, Finkelstein, D, Kastan, MB, and Pui, C-H. "Deficient innate immunity, thymopoiesis, and gene expression response to radiation in survivors of childhood acute lymphoblastic leukemia." Cancer Epidemiology 34, no. 3 (June 2010): 303-308. Full Text
  - Alexander, A, Cai, S-L, Kim, J, Nanez, A, Sahin, M, MacLean, KH, Inoki, K, Guan, K-L, Shen, J, Person, MD, Kusewitt, D, Mills, GB, Kastan, MB, and Walker, CL. "Abstract 4831: ATM signals to TSC2 in the cytoplasm to regulate mTORC1 and autophagy in response to ROS." Cancer Research 70, no. 8 Supplement (April 15, 2010): 4831-4831. Full Text
  - Zaki, MH, Boyd, KL, Vogel, P, Kastan, MB, Lamkanfi, M, and Kanneganti, T-D. "The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis." Immunity 32, no. 3 (March 18, 2010): 379-391. Full Text
  - Alexander, A, Cai, S-L, Kim, J, Nanez, A, Sahin, M, MacLean, KH, Inoki, K, Guan, K-L, Shen, J, Person, MD, Kusewitt, D, Mills, GB, Kastan, MB, and Walker, CL. "ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS." Proceedings of the National Academy of Sciences of the United States of America 107, no. 9 (March 2010): 4153-4158. Full Text
  - Ofir-Rosenfeld, Y, Boggs, K, Michael, D, Kastan, MB, and Oren, M. "Mdm2 regulates p53 mRNA translation through inhibitory interactions with ribosomal protein L26." Molecular Cell 32, no. 2 (October 2008): 180-189. Full Text
  - Rainey, MD, Charlton, ME, Stanton, RV, and Kastan, MB. "Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation." Cancer Research 68, no. 18 (September 2008): 7466-7474. Full Text
  - Chandhasin, C, Ducu, RI, Berkovich, E, Kastan, MB, and Marriott, SJ. "Human T-cell leukemia virus type 1 tax attenuates the ATM-mediated cellular DNA damage response." Journal of Virology 82, no. 14 (July 2008): 6952-6961. Full Text
  - Loehberg, CR, Thompson, T, Kastan, MB, O'Malley, BW, and Beckmann, MW. "ATM and p53 are potential mediators of Chloroquine-induced resistance to mammary carcinogenesis." GEBURTSHILFE UND FRAUENHEILKUNDE 68, no. 5 (May 2008): 557-557. Link to Item
  - Kastan, MB. "DNA damage responses: mechanisms and roles in human disease: 2007 G.H.A. Clowes Memorial Award Lecture." Molecular Cancer Research : Mcr 6, no. 4 (April 2008): 517-524. Full Text
  - Maclean, KH, Dorsey, FC, Cleveland, JL, and Kastan, MB. "Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis (Journal of Clinical Investigation (2008) 118, (79-88) DOI: 10.1172/JCI33700)." Journal of Clinical Investigation 118, no. 4 (April 1, 2008): 1584-null. Full Text
  - Maclean, KH, Dorsey, FC, Cleveland, JL, and Kastan, MB. "Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis." Journal of Clinical Investigation 118, no. 4 (April 1, 2008): 1584-1584. Full Text
  - Tang, X, Hui, Z-G, Cui, X-L, Garg, R, Kastan, MB, and Xu, B. "A novel ATM-dependent pathway regulates protein phosphatase 1 in response to DNA damage." Molecular and Cellular Biology 28, no. 8 (April 2008): 2559-2566. Full Text
  - Berkovich, E, Monnat, RJ, and Kastan, MB. "Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites." Nature Protocols 3, no. 5 (January 2008): 915-922. Full Text
  - Maclean, KH, Dorsey, FC, Cleveland, JL, and Kastan, MB. "Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis." The Journal of Clinical Investigation 118, no. 1 (January 2008): 79-88. Full Text
  - Loehberg, CR, Thompson, T, Kastan, MB, Maclean, KH, Edwards, DG, Kittrell, FS, Medina, D, Conneely, OM, and O'Malley, BW. "Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis." Cancer Research 67, no. 24 (December 2007): 12026-12033. Full Text
  - Kastan, MB. "Our cells get stressed too! Implications for human disease." Blood Cells, Molecules & Diseases 39, no. 2 (September 2007): 148-150. Full Text
  - Maclean, KH, Kastan, MB, and Cleveland, JL. "Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis." Molecular Cancer Research : Mcr 5, no. 7 (July 2007): 705-711. Full Text
  - Berkovich, E, Monnat, RJ, and Kastan, MB. "Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair." Nature Cell Biology 9, no. 6 (June 2007): 683-690. Full Text
  - Kastan, MB, and Berkovich, E. "p53: a two-faced cancer gene." Nature Cell Biology 9, no. 5 (May 2007): 489-491. Full Text
  - Kastan, MB. "Wild-type p53: tumors can't stand it." Cell 128, no. 5 (March 2007): 837-840. (Review) Full Text
  - Kastan, MB. "A message from the editor." Molecular Cancer Research 5, no. 11 (2007): xii-.
  - Kastan, MB. "Editor's note." Molecular Cancer Research 5, no. 1 (2007): viii-.
  - Schneider, JG, Finck, BN, Ren, J, Standley, KN, Takagi, M, Maclean, KH, Bernal-Mizrachi, C, Muslin, AJ, Kastan, MB, and Semenkovich, CF. "ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome." Cell Metabolism 4, no. 5 (November 2006): 377-389. Full Text
  - Sandlund, JT, Kastan, MB, Kennedy, W, Behm, F, Entrekin, E, Pui, C-H, Kalwinsky, DT, and Raimondi, SC. "A subtle t(3;8) results in plausible juxtaposition of MYC and BCL6 in a child with Burkitt lymphoma/leukemia and ataxia-telangiectasia." Cancer Genetics and Cytogenetics 168, no. 1 (July 2006): 69-72. Full Text
  - Bekker-Jensen, S, Lukas, C, Kitagawa, R, Melander, F, Kastan, MB, Bartek, J, and Lukas, J. "Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks." The Journal of Cell Biology 173, no. 2 (April 17, 2006): 195-206. Full Text
  - Morales, M, Theunissen, J-WF, Kim, CFB, Kitagawa, R, Kastan, MB, and Petrini, JHJ. "The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor." Genes & Development 19, no. 24 (December 2005): 3043-3054. Full Text
  - Takagi, M, Absalon, MJ, McLure, KG, and Kastan, MB. "Erratum: Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin (Cell (October 7, 2005) 123 (49-63))." Cell 123, no. 3 (November 4, 2005): 536-537. Full Text
  - Kastan, MB. "DNA damage responses: Cancer and beyond." Scientist 19, no. 19 (October 10, 2005): 24-25.
  - Kastan, MB. "Cell biology: A BID for the pathway." Nature 437, no. 7062 (October 2005): 1103-null. Full Text
  - Takagi, M, Absalon, MJ, McLure, KG, and Kastan, MB. "Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin." Cell 123, no. 1 (October 2005): 49-63. Full Text
  - Bartkova, J, Bakkenist, CJ, Rajpert-De Meyts, E, Skakkebaek, NE, Sehested, M, Lukas, J, Kastan, MB, and Bartek, J. "ATM activation in normal human tissues and testicular cancer." Cell Cycle (Georgetown, Tex.) 4, no. 6 (June 13, 2005): 838-845. Full Text
  - Kitagawa, R, and Kastan, MB. "The ATM-dependent DNA damage signaling pathway." Cold Spring Harbor Symposia on Quantitative Biology 70 (January 2005): 99-109. (Review) Full Text
  - Kastan, MB, and Bartek, J. "Cell-cycle checkpoints and cancer." Nature 432, no. 7015 (November 18, 2004): 316-323. (Review) Full Text Link to Item
  - McLure, KG, Takagi, M, and Kastan, MB. "NAD+ modulates p53 DNA binding specificity and function." Molecular and Cellular Biology 24, no. 22 (November 2004): 9958-9967. Full Text
  - Karlseder, J, Hoke, K, Mirzoeva, OK, Bakkenist, C, Kastan, MB, Petrini, JHJ, and de Lange, T. "The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response." Plos Biology 2, no. 8 (August 17, 2004): E240-null. Full Text
  - Arlt, MF, Xu, B, Durkin, SG, Casper, AM, Kastan, MB, and Glover, TW. "BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function." Molecular and Cellular Biology 24, no. 15 (August 2004): 6701-6709. Full Text
  - Bakkenist, CJ, and Kastan, MB. "Initiating cellular stress responses." Cell 118, no. 1 (July 2004): 9-17. (Review) Full Text
  - Bakkenist, CJ, and Kastan, MB. "Phosphatases join kinases in DNA-damage response pathways." Trends in Cell Biology 14, no. 7 (July 2004): 339-341. (Review) Full Text
  - Kitagawa, R, Bakkenist, CJ, McKinnon, PJ, and Kastan, MB. "Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway." Genes & Development 18, no. 12 (June 2, 2004): 1423-1438. Full Text
  - Bakkenist, CJ, Drissi, R, Wu, J, Kastan, MB, and Dome, JS. "Disappearance of the telomere dysfunction-induced stress response in fully senescent cells." Cancer Research 64, no. 11 (June 2004): 3748-3752. Full Text
  - Garg, R, Callens, S, Lim, D-S, Canman, CE, Kastan, MB, and Xu, B. "Chromatin association of rad17 is required for an ataxia telangiectasia and rad-related kinase-mediated S-phase checkpoint in response to low-dose ultraviolet radiation." Molecular Cancer Research : Mcr 2, no. 6 (June 2004): 362-369.
  - Surrallés, J, Jackson, SP, Jasin, M, Kastan, MB, West, SC, and Joenje, H. "Molecular cross-talk among chromosome fragility syndromes." Genes & Development 18, no. 12 (June 2004): 1359-1370. Full Text
  - Horejsí, Z, Falck, J, Bakkenist, CJ, Kastan, MB, Lukas, J, and Bartek, J. "Distinct functional domains of Nbs1 modulate the timing and magnitude of ATM activation after low doses of ionizing radiation." Oncogene 23, no. 17 (April 2004): 3122-3127. Full Text
  - Kastan, MB. "ATM–the first step in helping cells deal with DNA damage." Biomedicine & Pharmacotherapy 58, no. 1 (January 2004): 72-73. Full Text
  - Xu, B, and Kastan, MB. "Analyzing cell cycle checkpoints after ionizing radiation." Methods Mol Biol 281 (2004): 283-292. Full Text Link to Item
  - Cortés, ML, Bakkenist, CJ, Di Maria, MV, Kastan, MB, and Breakefield, XO. "HSV-1 amplicon vector-mediated expression of ATM cDNA and correction of the ataxia-telangiectasia cellular phenotype." Gene Therapy 10, no. 16 (August 2003): 1321-1327. Full Text
  - Lee, JH, Xu, B, Lee, C-H, Ahn, J-Y, Song, MS, Lee, H, Canman, CE, Lee, J-S, Kastan, MB, and Lim, D-S. "Distinct functions of Nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage." Molecular Cancer Research : Mcr 1, no. 9 (July 2003): 674-681.
  - Bakkenist, CJ, and Kastan, MB. "DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation." Nature 421, no. 6922 (January 2003): 499-506. Full Text
  - Kastan, MB, and Zambetti, GP. "Parc-ing p53 in the cytoplasm." Cell 112, no. 1 (January 2003): 1-2. Full Text
  - Kastan, MB. "Molecular Cancer Research: A Note from the Editor." Molecular Cancer Research 1, no. 14 (2003): vi-.
  - Nakanishi, K, Taniguchi, T, Ranganathan, V, New, HV, Moreau, LA, Stotsky, M, Mathew, CG, Kastan, MB, Weaver, DT, and D'Andrea, AD. "Interaction of FANCD2 and NBS1 in the DNA damage response." Nature Cell Biology 4, no. 12 (December 2002): 913-920. Full Text
  - Kastan, MB. "Welcome to molecular cancer research." Molecular Cancer Research 1, no. 1 (November 1, 2002): 1-null.
  - Xu, B, O'Donnell, AH, Kim, S-T, and Kastan, MB. "Phosphorylation of serine 1387 in Brca1 is specifically required for the Atm-mediated S-phase checkpoint after ionizing irradiation." Cancer Research 62, no. 16 (August 2002): 4588-4591.
  - Taniguchi, T, Garcia-Higuera, I, Xu, B, Andreassen, PR, Gregory, RC, Kim, S-T, Lane, WS, Kastan, MB, and D'Andrea, AD. "Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways." Cell 109, no. 4 (May 2002): 459-472. Full Text
  - Kim, S-T, Xu, B, and Kastan, MB. "Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage." Genes & Development 16, no. 5 (March 2002): 560-570. Full Text
  - Xu, B, Kim, S-T, Lim, D-S, and Kastan, MB. "Two molecularly distinct G(2)/M checkpoints are induced by ionizing irradiation." Molecular and Cellular Biology 22, no. 4 (February 2002): 1049-1059. Full Text
  - Taniguchi, T, Garcia-Higuera, I, Lane, WS, Kim, ST, Xu, B, Kastan, MB, and D'Andrea, AD. "Molecular interaction of the Fanconi Anemia (FA) and Ataxia Telangiectasia (AT) pathways." BLOOD 98, no. 11 (November 16, 2001): 782A-782A. Link to Item
  - D'Andrea, AD, Garcia-Higuera, I, Lane, WS, Xu, B, Kastan, MB, and Taniguchi, T. "Differential activation of the Fanconi Anemia protein, FANCD2, by monoubiquitination and phosphorylation." MOLECULAR BIOLOGY OF THE CELL 12 (November 2001): 5A-6A. Link to Item
  - Thomas, C, Ely, G, James, CD, Jenkins, R, Kastan, M, Jedlicka, A, Burger, P, and Wharen, R. "Glioblastoma-related gene mutations and over-expression of functional epidermal growth factor receptors in SKMG-3 glioma cells." Acta Neuropathologica 101, no. 6 (June 2001): 605-615.
  - Maya, R, Balass, M, Kim, ST, Shkedy, D, Leal, JF, Shifman, O, Moas, M, Buschmann, T, Ronai, Z, Shiloh, Y, Kastan, MB, Katzir, E, and Oren, M. "ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage." Genes & Development 15, no. 9 (May 2001): 1067-1077. Full Text
  - Xu, B, Kim St, , and Kastan, MB. "Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation." Molecular and Cellular Biology 21, no. 10 (May 2001): 3445-3450. Full Text
  - Kastan, MB. "Cell cycle. Checking two steps." Nature 410, no. 6830 (April 2001): 766-767. Full Text
  - Koumenis, C, Alarcon, R, Hammond, E, Sutphin, P, Hoffman, W, Murphy, M, Derr, J, Taya, Y, Lowe, SW, Kastan, M, and Giaccia, A. "Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation." Molecular and Cellular Biology 21, no. 4 (February 2001): 1297-1310. Full Text
  - Kastan, MB, Lim, DS, Kim, ST, and Yang, D. "ATM--a key determinant of multiple cellular responses to irradiation." Acta Oncologica (Stockholm, Sweden) 40, no. 6 (January 2001): 686-688. (Review) Full Text
  - Shiloh, Y, and Kastan, MB. "ATM: genome stability, neuronal development, and cancer cross paths." Advances in Cancer Research 83 (January 2001): 209-254. (Review) Full Text
  - Kastan, MB, and Lim, DS. "The many substrates and functions of ATM." Nature Reviews. Molecular Cell Biology 1, no. 3 (December 2000): 179-186. (Review) Full Text
  - Yang, DQ, and Kastan, MB. "Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1." Nature Cell Biology 2, no. 12 (December 2000): 893-898. Full Text
  - Cleveland, JL, and Kastan, MB. "Cancer. A radical approach to treatment." Nature 407, no. 6802 (September 2000): 309-311. Full Text
  - Lim, DS, Kim, ST, Xu, B, Maser, RS, Lin, J, Petrini, JH, and Kastan, MB. "ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway." Nature 404, no. 6778 (April 2000): 613-617. Full Text
  - Pandita, TK, Lieberman, HB, Lim, DS, Dhar, S, Zheng, W, Taya, Y, and Kastan, MB. "Ionizing radiation activates the ATM kinase throughout the cell cycle." Oncogene 19, no. 11 (March 2000): 1386-1391. Full Text
  - Kastan, MB, Lim, DS, Kim, ST, Xu, B, and Canman, C. "Multiple signaling pathways involving ATM." Cold Spring Harbor Symposia on Quantitative Biology 65 (January 2000): 521-526. (Review) Full Text
  - Ziv, Y, Banin, S, Lim, DS, Canman, CE, Kastan, MB, and Shiloh, Y. "Expression and assay of recombinant ATM." Methods Mol Biol 99 (2000): 99-108. (Review) Full Text Link to Item
  - Kim, ST, Lim, DS, Canman, CE, and Kastan, MB. "Substrate specificities and identification of putative substrates of ATM kinase family members." The Journal of Biological Chemistry 274, no. 53 (December 1999): 37538-37543. Full Text
  - DiGiuseppe, JA, Weng, LJ, Yu, KH, Fu, S, Kastan, MB, Samid, D, and Gore, SD. "Phenylbutyrate-induced G1 arrest and apoptosis in myeloid leukemia cells: structure-function analysis." Leukemia 13, no. 8 (August 1999): 1243-1253. Link to Item
  - Kastan, MB. "Molecular determinants of sensitivity to antitumor agents." Biochimica Et Biophysica Acta 1424, no. 1 (July 1999): R37-R42. Full Text
  - Kirsch, DG, Doseff, A, Chau, BN, Lim, DS, de Souza-Pinto, NC, Hansford, R, Kastan, MB, Lazebnik, YA, and Hardwick, JM. "Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c." The Journal of Biological Chemistry 274, no. 30 (July 1999): 21155-21161. Full Text
  - DiGiuseppe, JA, Kastan, MB, Weng, LJ, and Gore, SD. "Cytoprotective effects of hematopoietic growth factors on primary human acute myeloid leukemias are not mediated through changes in BCL-2, bax, or p21WAF1/CIP1." In Vivo (Athens, Greece) 13, no. 1 (January 1999): 1-6.
  - Rhodes, N, D'Souza, T, Foster, CD, Ziv, Y, Kirsch, DG, Shiloh, Y, Kastan, MB, Reinhart, PH, and Gilmer, TM. "Defective potassium currents in ataxia telangiectasia fibroblasts." Genes & Development 12, no. 23 (December 1998): 3686-3692. Full Text
  - Westphal, CH, Hoyes, KP, Canman, CE, Huang, X, Kastan, MB, Hendry, JH, and Leder, P. "Loss of atm radiosensitizes multiple p53 null tissues." Cancer Research 58, no. 24 (December 1998): 5637-5639.
  - Leung, W, Chen, AR, Klann, RC, Moss, TJ, Davis, JM, Noga, SJ, Cohen, KJ, Friedman, AD, Small, D, Schwartz, CL, Borowitz, MJ, Wharam, MD, Paidas, CN, Long, CA, Karandish, S, McMannis, JD, Kastan, MB, and Civin, CI. "Frequent detection of tumor cells in hematopoietic grafts in neuroblastoma and Ewing's sarcoma." Bone Marrow Transplant 22, no. 10 (November 1998): 971-979. Full Text Link to Item
  - Giaccia, AJ, and Kastan, MB. "The complexity of p53 modulation: emerging patterns from divergent signals." Genes & Development 12, no. 19 (October 1998): 2973-2983. (Review) Full Text
  - Canman, CE, Lim, DS, Cimprich, KA, Taya, Y, Tamai, K, Sakaguchi, K, Appella, E, Kastan, MB, and Siliciano, JD. "Activation of the ATM kinase by ionizing radiation and phosphorylation of p53." Science (New York, N.Y.) 281, no. 5383 (September 1998): 1677-1679. Full Text
  - Kirsch, DG, and Kastan, MB. "Tumor-suppressor p53: implications for tumor development and prognosis." Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology 16, no. 9 (September 1998): 3158-3168. (Review) Full Text
  - Lim, DS, Kirsch, DG, Canman, CE, Ahn, JH, Ziv, Y, Newman, LS, Darnell, RB, Shiloh, Y, and Kastan, MB. "ATM binds to beta-adaptin in cytoplasmic vesicles." Proceedings of the National Academy of Sciences of the United States of America 95, no. 17 (August 1998): 10146-10151. Full Text
  - Comer, KA, Dennis, PA, Armstrong, L, Catino, JJ, Kastan, MB, and Kumar, CC. "Human smooth muscle alpha-actin gene is a transcriptional target of the p53 tumor suppressor protein." Oncogene 16, no. 10 (March 1998): 1299-1308. Full Text
  - Canman, CE, and Kastan, MB. "Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis." Oncogene 16, no. 8 (February 26, 1998): 957-966. Full Text Link to Item
  - Clem, RJ, Cheng, EH, Karp, CL, Kirsch, DG, Ueno, K, Takahashi, A, Kastan, MB, Griffin, DE, Earnshaw, WC, Veliuona, MA, and Hardwick, JM. "Modulation of cell death by Bcl-XL through caspase interaction." Proc Natl Acad Sci U S A 95, no. 2 (January 20, 1998): 554-559. Link to Item
  - Dennis, PA, and Kastan, MB. "Cellular survival pathways and resistance to cancer therapy." Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy 1, no. 5 (January 1998): 301-309. Full Text
  - Cheng, EH, Kirsch, DG, Clem, RJ, Ravi, R, Kastan, MB, Bedi, A, Ueno, K, and Hardwick, JM. "Conversion of Bcl-2 to a Bax-like death effector by caspases." Science 278, no. 5345 (December 12, 1997): 1966-1968. Link to Item
  - Kastan, MB, Morgan, SE, Siliciano, J, Kirsch, D, Dennis, P, and Canman, CE. "Cell cycle and cell death after DNA damaye." Faseb Journal 11, no. 9 (December 1, 1997).
  - Siliciano, JD, Canman, CE, Taya, Y, Sakaguchi, K, Appella, E, and Kastan, MB. "DNA damage induces phosphorylation of the amino terminus of p53." Genes & Development 11, no. 24 (December 1997): 3471-3481. Full Text
  - Kastan, MB. "To oxidize or not to oxidize?." Nat Med 3, no. 11 (November 1997): 1192-1193. Link to Item
  - Smilenov, LB, Morgan, SE, Mellado, W, Sawant, SG, Kastan, MB, and Pandita, TK. "Influence of ATM function on telomere metabolism." Oncogene 15, no. 22 (November 1997): 2659-2665. Full Text
  - Agani, F, Kirsch, DG, Friedman, SL, Kastan, MB, and Semenza, GL. "p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene." Cancer Research 57, no. 20 (October 1997): 4474-4477.
  - Metcalfe, SM, Canman, CE, Milner, J, Morris, RE, Goldman, S, and Kastan, MB. "Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells." Oncogene 15, no. 14 (October 1997): 1635-1642. Full Text
  - Chabner, BA, Kastan, MB, and Teicher, BA. "Untitled." CLINICAL CANCER RESEARCH 3, no. 9 (September 1997): 1455-1455. Link to Item
  - Morgan, SE, and Kastan, MB. "Dissociation of radiation-induced phosphorylation of replication protein A from the S-phase checkpoint." Cancer Res 57, no. 16 (August 15, 1997): 3386-3389. Link to Item
  - Kastan, MB, Morgan, SE, Siliciano, J, Kirsch, D, Dennis, P, and Canman, CE. "Cell cycle and cell death after DNA damage." FASEB JOURNAL 11, no. 9 (July 31, 1997): A879-A879. Link to Item
  - Baskaran, R, Wood, LD, Whitaker, LL, Canman, CE, Morgan, SE, Xu, Y, Barlow, C, Baltimore, D, Wynshaw-Boris, A, Kastan, MB, and Wang, JY. "Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation." Nature 387, no. 6632 (May 1997): 516-519. Full Text
  - DiGiuseppe, JA, and Kastan, MB. "Apoptosis in haematological malignancies." Journal of Clinical Pathology 50, no. 5 (May 1997): 361-364. Full Text
  - Morgan, SE, Lovly, C, Pandita, TK, Shiloh, Y, and Kastan, MB. "Fragments of ATM which have dominant-negative or complementing activity." Molecular and Cellular Biology 17, no. 4 (April 1997): 2020-2029. Full Text
  - Canman, CE, and Kastan, MB. "Role of p53 in apoptosis." Adv Pharmacol 41 (1997): 429-460. (Review) Link to Item
  - Kastan, M. "On the TRAIL from p53 to apoptosis?." Nature genetics 17, no. 2 (1997): 130-131.
  - Kastan, MB. "Genetic instability and tumorigenesis: introduction." Curr Top Microbiol Immunol 221 (1997): 1-4. Link to Item
  - Kastan, MB. "Checkpoint controls and cancer. Introduction." Cancer Surv 29 (1997): 1-6. Link to Item
  - Morgan, SE, and Kastan, MB. "p53 and ATM: cell cycle, cell death, and cancer." Advances in Cancer Research 71 (January 1997): 1-25. (Review)
  - DiGiuseppe, JA, Gore, SD, Weng, LJ, and Kastan, MB. "Growth factor modulation of p21(WAF1/CIP1) in primary acute myeloid leukemias." BLOOD 88, no. 10 (November 15, 1996): 331-331. Link to Item
  - Canman, CE, and Kastan, MB. "Signal transduction. Three paths to stress relief." Nature 384, no. 6606 (November 1996): 213-214. Full Text
  - Pandita, TK, Hall, EJ, Hei, TK, Piatyszek, MA, Wright, WE, Piao, CQ, Pandita, RK, Willey, JC, Geard, CR, Kastan, MB, and Shay, JW. "Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny." Oncogene 13, no. 7 (October 1996): 1423-1430.
  - Chen, CY, Hall, I, Lansing, TJ, Gilmer, TM, Tlsty, TD, and Kastan, MB. "Separate pathways for p53 induction by ionizing radiation and N-(phosphonoacetyl)-L-aspartate." Cancer Research 56, no. 16 (August 1996): 3659-3662.
  - Inaba, T, Inukai, T, Yoshihara, T, Seyschab, H, Ashmun, RA, Canman, CE, Laken, SJ, Kastan, MB, and Look, AT. "Reversal of apoptosis by the leukaemia-associated E2A-HLF chimaeric transcription factor." Nature 382, no. 6591 (August 1996): 541-544. Full Text
  - Kastan, MB. "Signalling to p53: where does it all start?." Bioessays 18, no. 8 (August 1996): 617-619. (Review) Full Text Link to Item
  - Goldman, SC, Chen, CY, Lansing, TJ, Gilmer, TM, and Kastan, MB. "The p53 signal transduction pathway is intact in human neuroblastoma despite cytoplasmic localization." The American Journal of Pathology 148, no. 5 (May 1996): 1381-1385.
  - Gerson, SL, Phillips, W, Kastan, M, Dumenco, LL, and Donovan, C. "Human CD34⁺ hematopoietic progenitors have low, cytokine-unresponsive O⁶-alkylguanine-DNA alkyltransferase and are sensitive to O⁶-benzylguanine plus BCNU." Blood 88, no. 5 (1996): 1649-1655.
  - Liebermann, DA, Myers, A, Weinhouse, S, Nowell, PC, Jr, AJF, Kastan, MB, White, E, Tisty, TD, Ihle, JN, Waxman, S, and Reddy, P. "Molecular biology of normal development, malignancy and its suppression." Oncogene 12, no. 10 (1996): 2247-2250.
  - Inaba, T, Inukai, T, Yoshihara, T, Seyschab, H, Ashmun, RA, Canman, CE, Laken, SJ, Kastan, MB, and Look, AT. "The oncogenic E2A-HLF fusion protein protects leukemic B-precursor cells from apoptosis." BLOOD 86, no. 10 (November 15, 1995): 1297-1297. Link to Item
  - Yao, S, Akhtar, AJ, Bedi, GC, Sidransky, D, Kastan, MB, Barber, JP, McKenna, KA, Collector, MI, Sharkis, SJ, Jones, RJ, and Bedi, A. "DNA damage induced apoptosis by p53-mediated activation of p34(cdc2) kinase." BLOOD 86, no. 10 (November 15, 1995): 1714-1714. Link to Item
  - Kilpatrick, KE, Carrier, F, Smith, ML, Chen, CY, Lee, AJ, Rusnak, DW, Kastan, MB, Fornace, AJ, Champion, BR, and Gilmer, TM. "The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein." Hybridoma 14, no. 4 (August 1995): 355-359. Full Text Link to Item
  - Canman, CE, Gilmer, TM, Coutts, SB, and Kastan, MB. "Growth factor modulation of p53-mediated growth arrest versus apoptosis." Genes & Development 9, no. 5 (March 1995): 600-611. Full Text
  - Kastan, MB, Canman, CE, and Leonard, CJ. "P53, cell cycle control and apoptosis: implications for cancer." Cancer Metastasis Reviews 14, no. 1 (March 1995): 3-15. (Review) Full Text
  - Canman, CE, and Kastan, MB. "Induction of apoptosis by tumor suppressor genes and oncogenes." Semin Cancer Biol 6, no. 1 (February 1995): 17-25. (Review) Full Text Link to Item
  - Kastan, M. "Ataxia-telangiectasia - Broad implications for a rare disorder." New England Journal of Medicine 333, no. 10 (1995): 662-663. Full Text
  - Leonard, CJ, Canman, CE, and Kastan, MB. "The role of p53 in cell-cycle control and apoptosis: implications for cancer." Important Adv Oncol (1995): 33-42. (Review) Link to Item
  - Zhan, Q, El-Deiry, W, Bae, I, Alamo, I, Kastan, MB, Vogelstein, B, and Jr, AF. "Similarity of the DNA-damage responsiveness and growth-suppressive properties of WAF1/CIP1 and GADD45." International Journal of Oncology 6, no. 5 (1995): 937-946.
  - Hartwell, LH, and Kastan, MB. "Cell cycle control and cancer." Science (New York, N.Y.) 266, no. 5192 (December 1994): 1821-1828. (Review) Full Text
  - Smith, ML, Chen, IT, Zhan, Q, Bae, I, Chen, CY, Gilmer, TM, Kastan, MB, O'Connor, PM, and Fornace, AJ. "Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen." Science (New York, N.Y.) 266, no. 5189 (November 1994): 1376-1380. Full Text
  - Canman, CE, Wolff, AC, Chen, CY, Fornace, AJ, and Kastan, MB. "The p53-dependent G1 cell cycle checkpoint pathway and ataxia-telangiectasia." Cancer Research 54, no. 19 (October 1994): 5054-5058.
  - Slebos, RJ, Lee, MH, Plunkett, BS, Kessis, TD, Williams, BO, Jacks, T, Hedrick, L, Kastan, MB, and Cho, KR. "p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein." Proceedings of the National Academy of Sciences of the United States of America 91, no. 12 (June 1994): 5320-5324. Full Text
  - Zhan, Q, Bae, I, Kastan, MB, and Fornace, AJ. "The p53-dependent gamma-ray response of GADD45." Cancer Research 54, no. 10 (May 1994): 2755-2760.
  - Chen, CY, Oliner, JD, Zhan, Q, Fornace, AJ, Vogelstein, B, and Kastan, MB. "Interactions between p53 and MDM2 in a mammalian cell cycle checkpoint pathway." Proceedings of the National Academy of Sciences of the United States of America 91, no. 7 (March 1994): 2684-2688. Full Text
  - Nelson, WG, and Kastan, MB. "DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways." Molecular and Cellular Biology 14, no. 3 (March 1994): 1815-1823. Full Text
  - el-Deiry, WS, Harper, JW, O'Connor, PM, Velculescu, VE, Canman, CE, Jackman, J, Pietenpol, JA, Burrell, M, Hill, DE, and Wang, Y. "WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis." Cancer Research 54, no. 5 (March 1994): 1169-1174.
  - KASTAN, MB, NELSON, WG, CHEN, CY, and SLICHENMYER, WB. "P53 AND OTHER MOLECULAR CONTROLS OF THE RESPONSE TO DNA-DAMAGE." JOURNAL OF CELLULAR BIOCHEMISTRY (February 13, 1994): 164-164. Link to Item
  - KASTAN, MB, NELSON, WG, CHEN, CY, and SLICHENMYER, WB. "P53 AND OTHER MOLECULAR CONTROLS OF THE RESPONSE TO DNA-DAMAGE." JOURNAL OF CELLULAR BIOCHEMISTRY (February 13, 1994): 209-209. Link to Item
  - Canman, CE, Chen, CY, Lee, MH, and Kastan, MB. "DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis." Cold Spring Harbor Symposia on Quantitative Biology 59 (January 1994): 277-286. (Review) Full Text
  - Carrier, F, Smith, ML, Bae, I, Kilpatrick, KE, Lansing, TJ, Chen-, CY, Engelstein, M, Friend, SH, Henner, WD, Gilmer, TM, Kastan, MB, and Jr, AJF. "Characterization of human Gadd45, a p53-regulated protein." Journal of Biological Chemistry 269, no. 51 (1994): 32672-32677.
  - Wechsler, DS, Kastan, MB, and Fivush, BA. "Resolution of nephrocalcinosis associated with tumor lysis syndrome." Pediatr Hematol Oncol 11, no. 1 (January 1994): 115-118. (Letter) Link to Item
  - Kastan, MB, and Kuerbitz, SJ. "Control of G1 arrest after DNA damage." Environmental Health Perspectives 101 Suppl 5 (December 1993): 55-58. (Review) Full Text
  - Moran, , Kastan, MB, DeCabrio, , Mihich, E, and Kufe, . "Discussion of Dr. Kastan's presentation." Advances in Experimental Medicine and Biology 339 (December 1, 1993): 295-296.
  - Kastan, MB. "Experimental models of human carcinogenesis." Nat Genet 5, no. 3 (November 1993): 207-208. Full Text Link to Item
  - KASTAN, MB. "HOT PAPERS - ONCOLOGY - PARTICIPATION OF P53 PROTEIN IN THE CELLULAR-RESPONSE TO DNA-DAMAGE BY KASTAN,M.B., ONYEKWERE,O., SIDRANSKY,D., ET-AL." SCIENTIST 7, no. 18 (September 20, 1993): 16-16. Link to Item
  - Slichenmyer, WJ, Nelson, WG, Slebos, RJ, and Kastan, MB. "Loss of a p53-associated G1 checkpoint does not decrease cell survival following DNA damage." Cancer Res 53, no. 18 (September 15, 1993): 4164-4168. Link to Item
  - Craig, RW, Buchan, HL, Civin, CI, and Kastan, MB. "Altered cytoplasmic/nuclear distribution of the c-myc protein in differentiating ML-1 human myeloid leukemia cells." Cell Growth Differ 4, no. 5 (May 1993): 349-357. Link to Item
  - Kessis, TD, Slebos, RJ, Nelson, WG, Kastan, MB, Plunkett, BS, Han, SM, Lorincz, AT, Hedrick, L, and Cho, KR. "Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage." Proceedings of the National Academy of Sciences of the United States of America 90, no. 9 (May 1993): 3988-3992. Full Text
  - ZHAN, QM, KASTAN, MB, CARRIER, F, HOLLANDER, MC, and FORNACE, AJ. "IDENTIFICATION OF A P53-REGULATED GENE INVOLVED IN A CELL-CYCLE CHECKPOINT ACTIVATED BY DNA DAMAGE." JOURNAL OF CELLULAR BIOCHEMISTRY (January 9, 1993): 141-141. Link to Item
  - Kastan, MB. "P53: a determinant of the cell cycle response to DNA damage." Adv Exp Med Biol 339 (1993): 291-293. Link to Item
  - Resar, LM, Phillips, PC, Kastan, MB, Leventhal, BG, Bowman, PW, and Civin, CI. "Acute neurotoxicity after intrathecal cytosine arabinoside in two adolescents with acute lymphoblastic leukemia of B-cell type." Cancer 71, no. 1 (January 1993): 117-123. Full Text
  - Kastan, MB, Zhan, Q, el-Deiry, WS, Carrier, F, Jacks, T, Walsh, WV, Plunkett, BS, Vogelstein, B, and Fornace, AJ. "A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia." Cell 71, no. 4 (November 1992): 587-597. Full Text
  - Kuerbitz, SJ, Plunkett, BS, Walsh, WV, and Kastan, MB. "Wild-type p53 is a cell cycle checkpoint determinant following irradiation." Proceedings of the National Academy of Sciences of the United States of America 89, no. 16 (August 1992): 7491-7495. Full Text
  - Kastan, MB, Onyekwere, O, Sidransky, D, Vogelstein, B, and Craig, RW. "Participation of p53 protein in the cellular response to DNA damage." Cancer Research 51, no. 23 Pt 1 (December 1991): 6304-6311.
  - Kastan, MB, Radin, AI, Kuerbitz, SJ, Onyekwere, O, Wolkow, CA, Civin, CI, Stone, KD, Woo, T, Ravindranath, Y, and Craig, RW. "Levels of p53 protein increase with maturation in human hematopoietic cells." Cancer Res 51, no. 16 (August 15, 1991): 4279-4286. Link to Item
  - Kaufmann, SH, McLaughlin, SJ, Kastan, MB, Liu, LF, Karp, JE, and Burke, PJ. "Topoisomerase II levels during granulocytic maturation in vitro and in vivo." Cancer Research 51, no. 13 (July 1991): 3534-3543.
  - Gore, SD, Kastan, MB, and Civin, CI. "Normal human bone marrow precursors that express terminal deoxynucleotidyl transferase include T-cell precursors and possible lymphoid stem cells." Blood 77, no. 8 (April 1991): 1681-1690.
  - KASTAN, M. "Levels of p53 protein increase with maturation in human hematopoietic cells." Cancer Res. 51 (1991): 4279-4286.
  - Kastan, MB, Onyekwere, O, Sidransky, D, Vogelstein, B, and Craig, RW. "Participation of p53 Protein in the Cellular Response to DNA Damage." Cancer Research 51 (January 1, 1991): 6304-6311.
  - Gore, SD, Kastan, MB, Goodman, SN, and Civin, CI. "Detection of minimal residual T cell acute lymphoblastic leukemia by flow cytometry." Journal of Immunological Methods 132, no. 2 (September 1990): 275-286. Full Text
  - Kastan, MB, Schlaffer, E, Russo, JE, Colvin, OM, Civin, CI, and Hilton, J. "Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells." Blood 75, no. 10 (May 1990): 1947-1950.
  - Kastan, MB, and Civin, CI. "Acute leukemia in children." Curr Opin Oncol 2, no. 1 (February 1990): 34-40. (Review) Link to Item
  - Gore, S, Kastan, M, and Civin, C. "Flow cytometric ientification of intracellular antigens: Detection of minimal residual leukemia." Bone Marrow Transplantation 6, no. SUPPL. 1 (1990): 39-41.
  - Kastan, MB, Stone, KD, and Civin, CI. "Nuclear oncoprotein expression as a function of lineage, differentiation stage, and proliferative status of normal human hematopoietic cells." Blood 74, no. 5 (October 1989): 1517-1524. Link to Item
  - Kastan, MB, Slamon, DJ, and Civin, CI. "Expression of protooncogene c-myb in normal human hematopoietic cells." Blood 73, no. 6 (May 1989): 1444-1451.
  - Kastan, MB, Strauss, LC, and Civin, CI. "The role of hematopoietic growth factors and oncogenes in leukemogenesis." Am J Pediatr Hematol Oncol 11, no. 3 (1989): 249-267. (Review) Link to Item
  - Kastan, MB, Zehnbauer, BA, Leventhal, BG, Corden, BJ, and Dover, GJ. "Philadelphia-chromosome positive essential thrombocythemia. Two cases in children." Am J Pediatr Hematol Oncol 11, no. 4 (1989): 433-436. Link to Item
  - KASTAN, MB, SLAMON, DJ, and CIVIN, CL. "PROTO-ONCOGENE C-MYB IS EXPRESSED IN NORMAL HUMAN HEMATOPOIETIC PROGENITOR CELLS." EXPERIMENTAL HEMATOLOGY 16, no. 6 (July 1988): 507-507. Link to Item
  - Barr, FG, Kastan, MB, and Lieberman, MW. "Distribution of 5-methyldeoxycytidine in products of staphylococcal nuclease digestion of nuclei and purified DNA." Biochemistry 24, no. 6 (March 1985): 1424-1428. Full Text
  - Barr, FG, Kastan, MB, and Lieberman, MW. "Distribution of 5-methyldeoxycytidine in products of staphylococcal nuclease digestion of nuclei and purified DNA." Federation Proceedings 43, no. 7 (January 1, 1984).
  - LIEBERMAN, MW, KASTAN, MB, and BARR, FG. "METHYLATION OF DEOXYCYTIDINE INCORPORATED BY REPAIR SYNTHESIS FOLLOWING DAMAGE WITH ULTRAVIOLET-RADIATION AND CHEMICAL CARCINOGENS." PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH 24, no. MAR (1983): 335-335. Link to Item
  - Kastan, MB, Gowans, BJ, and Lieberman, MW. "Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA." Cell 30, no. 2 (September 1982): 509-516. Link to Item
  - Smerdon, MJ, Kastan, MB, and Lieberman, MW. "Distribution of repair-incorporated nucleotides and nucleosome rearrangement in the chromatin of normal and xeroderma pigmentosum human fibroblasts." Biochemistry 18, no. 17 (August 21, 1979): 3732-3739. Link to Item
- Book Sections
  - Ford, JM, and Kastan, MB. "DNA Damage Response Pathways and Cancer." In Abeloff's Clinical Oncology: Fifth Edition, 142-153.e4. October 22, 2013. Full Text
  - McLure, KG, and Kastan, MB. "20 years of DNA damage signaling to p53." In 25 Years of p53 Research, 53-71. January 1, 2005. Full Text
- Conference Papers
  - Kastan, MB, Scarbrough, P, Chen, J, Brown, A, Crutchley, J, and Fleenor, D. "Abstract IA17: Non-canonical aspects of ATM and p53 signaling pathways." Abstracts: AACR Special Conference on DNA Repair: Tumor Development and Therapeutic Response; November 2-5, 2016; Montreal, QC, Canada.: American Association for Cancer Research, April 2017. Full Text
  - Musselwhite, LW, Schroeder, K, Bhattacharya, M, Vanderburg, SB, Masalu, NA, Chandy, M, Mauad, E, Bartlett, J, Kastan, MB, Merson, M, and Chao, NJA. "Duke University Global Cancer Program: A multidisciplinary approach to partnerships in global cancer care." : American Society of Clinical Oncology (ASCO), May 20, 2015. Full Text
  - Kastan, MB. "Abstract IA11: New insights into DNA double-strand break responses." : American Association for Cancer Research (AACR), December 1, 2014. Full Text
  - Bharatham, K, Suryadevara, PK, Guo, K, Min, J, Kastan, MB, Guy, RK, and Shelat, A. "Optimizing ATM inhibitor activity and specificity using pharmacophore-based docking." March 25, 2012. Link to Item
  - DeWire, MD, Pananandiker, ASP, Ellison, DE, McKinnon, PJ, Kastan, MB, and Gajjar, A. "RADIATION THERAPY AND ADJUVANT CHEMOTHERAPY IN A PATIENT WITH A HIGH GRADE GLIOMA AND UNDERLYING ATAXIA TELANGIECTASIA." June 2010. Link to Item
  - Kastan, MB, Kitagawa, R, and Bakkenist, CJ. "DNA damage response pathways in cancer causation and treatment." : Springer Nature, June 2005. Full Text
  - Loehberg, CR, Thompson, T, Kastan, MB, Conneely, OM, Medina, D, and O'Malley, BW. "Activation of ATM and p53 in mammary gland epithelial cells as a possible breast cancer prevention model." 2005. Link to Item
  - Schneider, JG, Ren, J, Feng, C, Coleman, T, Kastan, MB, Muslin, AJ, and Semenkovich, CF. "ATM haploinsufficiency produces vascular insulin resistance, impaired glucose tolerance, hypertension, and accelerated atherosclerosis in apoE null mice." May 2004. Link to Item
  - Arlt, MF, Durkin, SG, Casper, AM, Kastan, MB, and Glover, TW. "BRCA1 deficient cells have increased fragile site expression that is complemented by wild type BRCA1." October 2002. Link to Item
  - Kastan, MB, Lim, DS, Kim, ST, and Canman, CE. "Roles of TP53 and ATM in radiation responses." 2000. Link to Item
  - KASTAN, MB. "MOLECULAR CONTROLS OF CELL-CYCLE PROGRESSION FOLLOWING DNA-DAMAGE - ROLES OF P(53) AND ATAXIA-TELANGIECTASIA GENE-PRODUCTS." 1994. Link to Item
Teaching & Mentoring
Recent Courses

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

In the News

Awards & Honors

Selected Grants

Selected Publications

Books

Academic Articles

Book Sections

Conference Papers

Recent Courses