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Michael Barry Kastan

William and Jane Shingleton Distinguished Professor of Pharmacology and Cancer Biology
Pharmacology & Cancer Biology
DUMC Box 3917, 10 Bryan Searle Drive, Rm 422, Durham, NC 27710
DUMC Box 3917, 10 Bryan Searle Drive, Rm 422, Durham, NC 27710

Selected Grants


Medical Scientist Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027

Pharmacological Sciences Training Grant

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025

Non-canonical roles for ATM kinase in regulating mitochondrial function and redox homeostasis

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2025

Cancer Center Support Grant (CCSG)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1976 - 2024

Evaluation of kinase inhibitors

ResearchPrincipal Investigator · Awarded by XRAD THERAPEUTICS, INC. · 2016 - 2024

Medical Scientist Training Program

Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027

Pharmacological Sciences Training Grant

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025

Non-canonical roles for ATM kinase in regulating mitochondrial function and redox homeostasis

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2025

Cancer Center Support Grant (CCSG)

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1976 - 2024

Evaluation of kinase inhibitors

ResearchPrincipal Investigator · Awarded by XRAD THERAPEUTICS, INC. · 2016 - 2024

Kastan Gray Foundation Project

ResearchPrincipal Investigator · Awarded by Gray Foundation · 2017 - 2024

Does Loss of ATM Suppression of the SMG1 Kinase Contribute to the A-T Phenotype?

ResearchPrincipal Investigator · Awarded by Action for A-T · 2021 - 2023

C30 Canine Pilot Research

ResearchPrincipal Investigator · Awarded by V Foundation for Cancer Research · 2019 - 2023

The Role of USP22 in Prostate Cancer Development and Progression

ResearchMentor · Awarded by National Institutes of Health · 2019 - 2022

The role of ATM in Metabolic Stress Responses

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2022

Medical Scientist Training Program

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022

C30 Canine Pilot Research

ResearchPrincipal Investigator · Awarded by V Foundation for Cancer Research · 2016 - 2020

The role of Mtss1 in Hedgehog-mediated intestinal cancer stem cell function

ResearchMentor · Awarded by National Institutes of Health · 2015 - 2020

Pharmacological Sciences Training Program

Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by National Institutes of Health · 1975 - 2020

Stimulate Research in HIV/AIDS Cancer Research Projects at NCI-designated Cancer Centers

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2019

Collaborative Success: Expanding Options for Patients with Melanoma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1997 - 2019

Duke University Program in Environmental Health

Inst. Training Prgm or CMEMentor · Awarded by National Institute of Environmental Health Sciences · 2013 - 2019

Cellular Stress Response Signaling Pathways

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1992 - 2019

Copy Number Alterations in Low Mutation Cancer

ResearchCo-Mentor · Awarded by National Institutes of Health · 2018 - 2019

Identification of Therapeutic Interventions in Ataxia-Telangiectasia Using a Novel Model of Metabolic Stress

ResearchPrincipal Investigator · Awarded by University of Pennsylvania · 2017 - 2018

Center for Molecular & Cellular Studies of Ped Disease

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2018

Using bacterial CRISPR/Cas endonucleases to selectively eliminate HPV-transformed cells in vivo

ResearchCollaborator · Awarded by National Institutes of Health · 2015 - 2017

Development and Validation of Novel Therapeutic Targets in Anal Cancer

ResearchCollaborator · Awarded by The Farrah Fawcett Foundation · 2015 - 2016

Metabolic Sensing and Stress Response Deficit in Ataxia Telangiectasia

ResearchPrincipal Investigator · Awarded by A-T Children's Project · 2014 - 2016

Chromatin Modulation Associated with DNA Breakage and Repair in Human Cells

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2016

Cancer Biology Training Grant

Inst. Training Prgm or CMEMentor · Awarded by National Cancer Institute · 1993 - 2016

Evaluating GSK2126458 with radiation therapy in pre-clinical models

ResearchCo-Principal Investigator · Awarded by GlaxoSmithKline · 2013 - 2015

Screening for ATM/DNA-PK inhibitors

ResearchPrincipal Investigator · Awarded by GlaxoSmithKline · 2014 - 2015

External Relationships


  • BioSkryb, Inc.
  • Boston Children's Hospital
  • Dragon Therapeutics
  • Elsevier
  • Scientific Advisory Boards of the following Cancer Centers - UPenn, Univ Michigan, Stanford, UNC-CH, Cornell, USC
  • BioSkryb, Inc.
  • Boston Children's Hospital
  • Dragon Therapeutics
  • Elsevier
  • Scientific Advisory Boards of the following Cancer Centers - UPenn, Univ Michigan, Stanford, UNC-CH, Cornell, USC
  • Stand-up-to-Cancer (SU2C) and Jimmy V Foundation
  • X-Rad Therapeutics

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.