Philadelphia-chromosome positive essential thrombocythemia. Two cases in children.

Journal Article (Journal Article)

Two cases of children with essential thrombocythemia (ET) with the presence of a Philadelphia chromosome (Ph1) are presented and discussed. Diagnosis was based on their clinical presentation and marked primary thrombocytosis. The site of the Ph1 translocation, as detected by a 1.2-kb bcr genomic probe, differed in the two patients. These cases, along with other reported cases of Ph1-positive ET in the literature, suggest that the presence of the Ph1 cannot be used to rule out a diagnosis of ET. Additionally, the differing translocation sites in these cases suggests that the exact translocation site may not be significant in determining which cell lineage will predominate in a Ph1-positive myeloproliferative disorder.

Full Text

Duke Authors

Cited Authors

  • Kastan, MB; Zehnbauer, BA; Leventhal, BG; Corden, BJ; Dover, GJ

Published Date

  • 1989

Published In

Volume / Issue

  • 11 / 4

Start / End Page

  • 433 - 436

PubMed ID

  • 2618978

International Standard Serial Number (ISSN)

  • 0192-8562


  • eng

Conference Location

  • United States