Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling.
Publication
, Journal Article
Dasheiff, RM; McNamara, JO
Published in: Brain Res
August 18, 1980
Kindling induces a decline of hippocampal muscarinic cholinergic receptors. To test the hypthesis that the decline was mediated by the agonist, acetylcholine, adult male Sprague--Dawley rats were lesioned in the medial septum prior to kindling. Despite the marked destruction of presynaptic cholinergic terminals in the hippocampus, amygdala kindling proceeded normally and the hippocampal muscarinic receptor decline was not blocked. A small but significant decline in choline acetyltransferase activity was demonstrated in non-lesioned kindled rats. It is proposed that the kindling induced decline of hippocampal muscarinic receptors is mediated by repeated neuronal depolarization.
Duke Scholars
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
August 18, 1980
Volume
195
Issue
2
Start / End Page
345 / 353
Location
Netherlands
Related Subject Headings
- Septal Nuclei
- Seizures
- Receptors, Muscarinic
- Receptors, Cholinergic
- Rats
- Quinuclidinyl Benzilate
- Neurology & Neurosurgery
- Neural Pathways
- Male
- Hippocampus
Citation
APA
Chicago
ICMJE
MLA
NLM
Dasheiff, R. M., & McNamara, J. O. (1980). Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling. Brain Res, 195(2), 345–353. https://doi.org/10.1016/0006-8993(80)90070-0
Dasheiff, R. M., and J. O. McNamara. “Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling.” Brain Res 195, no. 2 (August 18, 1980): 345–53. https://doi.org/10.1016/0006-8993(80)90070-0.
Dasheiff RM, McNamara JO. Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling. Brain Res. 1980 Aug 18;195(2):345–53.
Dasheiff, R. M., and J. O. McNamara. “Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling.” Brain Res, vol. 195, no. 2, Aug. 1980, pp. 345–53. Pubmed, doi:10.1016/0006-8993(80)90070-0.
Dasheiff RM, McNamara JO. Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling. Brain Res. 1980 Aug 18;195(2):345–353.
Published In
Brain Res
DOI
ISSN
0006-8993
Publication Date
August 18, 1980
Volume
195
Issue
2
Start / End Page
345 / 353
Location
Netherlands
Related Subject Headings
- Septal Nuclei
- Seizures
- Receptors, Muscarinic
- Receptors, Cholinergic
- Rats
- Quinuclidinyl Benzilate
- Neurology & Neurosurgery
- Neural Pathways
- Male
- Hippocampus