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Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling.

Publication ,  Journal Article
Dasheiff, RM; McNamara, JO
Published in: Brain Res
August 18, 1980

Kindling induces a decline of hippocampal muscarinic cholinergic receptors. To test the hypthesis that the decline was mediated by the agonist, acetylcholine, adult male Sprague--Dawley rats were lesioned in the medial septum prior to kindling. Despite the marked destruction of presynaptic cholinergic terminals in the hippocampus, amygdala kindling proceeded normally and the hippocampal muscarinic receptor decline was not blocked. A small but significant decline in choline acetyltransferase activity was demonstrated in non-lesioned kindled rats. It is proposed that the kindling induced decline of hippocampal muscarinic receptors is mediated by repeated neuronal depolarization.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

August 18, 1980

Volume

195

Issue

2

Start / End Page

345 / 353

Location

Netherlands

Related Subject Headings

  • Septal Nuclei
  • Seizures
  • Receptors, Muscarinic
  • Receptors, Cholinergic
  • Rats
  • Quinuclidinyl Benzilate
  • Neurology & Neurosurgery
  • Neural Pathways
  • Male
  • Hippocampus
 

Citation

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ICMJE
MLA
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Dasheiff, R. M., & McNamara, J. O. (1980). Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling. Brain Res, 195(2), 345–353. https://doi.org/10.1016/0006-8993(80)90070-0
Dasheiff, R. M., and J. O. McNamara. “Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling.Brain Res 195, no. 2 (August 18, 1980): 345–53. https://doi.org/10.1016/0006-8993(80)90070-0.
Dasheiff, R. M., and J. O. McNamara. “Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling.Brain Res, vol. 195, no. 2, Aug. 1980, pp. 345–53. Pubmed, doi:10.1016/0006-8993(80)90070-0.
Dasheiff RM, McNamara JO. Evidence for an agonist independent down regulation of hippocampal muscarinic receptors in kindling. Brain Res. 1980 Aug 18;195(2):345–353.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

August 18, 1980

Volume

195

Issue

2

Start / End Page

345 / 353

Location

Netherlands

Related Subject Headings

  • Septal Nuclei
  • Seizures
  • Receptors, Muscarinic
  • Receptors, Cholinergic
  • Rats
  • Quinuclidinyl Benzilate
  • Neurology & Neurosurgery
  • Neural Pathways
  • Male
  • Hippocampus