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Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans.

Publication ,  Journal Article
Yashin, AI; Cypser, JR; Johnson, TE; Michalski, AI; Boyko, SI; Novoseltsev, VN
Published in: Mechanisms of ageing and development
September 2001

Stress experiments performed on a population of sterilised nematode worms (Caenorhabditis elegans) show a clear hormesis effect after short exposure and clear debilitation effects after long exposure to heat shock. An intermediate duration of exposure results in a mixture of these two effects. In this latter case the survival curves for populations in the stress and control groups intersect. In this paper we develop an adaptation model of stress and apply it to the analysis of survival data from three such stress experiments. We show that the model can be used to explain empirical age-patterns of mortality and survival observed in these experiments. We discuss possible biological mechanisms involved in stress response and directions for further research.

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Published In

Mechanisms of ageing and development

DOI

EISSN

1872-6216

ISSN

0047-6374

Publication Date

September 2001

Volume

122

Issue

13

Start / End Page

1477 / 1495

Related Subject Headings

  • Stress, Physiological
  • Models, Biological
  • Likelihood Functions
  • Heat-Shock Response
  • Gerontology
  • Caenorhabditis elegans
  • Animals
  • Aging
  • Adaptation, Physiological
  • 3202 Clinical sciences
 

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Yashin, A. I., Cypser, J. R., Johnson, T. E., Michalski, A. I., Boyko, S. I., & Novoseltsev, V. N. (2001). Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans. Mechanisms of Ageing and Development, 122(13), 1477–1495. https://doi.org/10.1016/s0047-6374(01)00273-1
Yashin, A. I., J. R. Cypser, T. E. Johnson, A. I. Michalski, S. I. Boyko, and V. N. Novoseltsev. “Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans.Mechanisms of Ageing and Development 122, no. 13 (September 2001): 1477–95. https://doi.org/10.1016/s0047-6374(01)00273-1.
Yashin AI, Cypser JR, Johnson TE, Michalski AI, Boyko SI, Novoseltsev VN. Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans. Mechanisms of ageing and development. 2001 Sep;122(13):1477–95.
Yashin, A. I., et al. “Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans.Mechanisms of Ageing and Development, vol. 122, no. 13, Sept. 2001, pp. 1477–95. Epmc, doi:10.1016/s0047-6374(01)00273-1.
Yashin AI, Cypser JR, Johnson TE, Michalski AI, Boyko SI, Novoseltsev VN. Ageing and survival after different doses of heat shock: the results of analysis of data from stress experiments with the nematode worm Caenorhabditis elegans. Mechanisms of ageing and development. 2001 Sep;122(13):1477–1495.
Journal cover image

Published In

Mechanisms of ageing and development

DOI

EISSN

1872-6216

ISSN

0047-6374

Publication Date

September 2001

Volume

122

Issue

13

Start / End Page

1477 / 1495

Related Subject Headings

  • Stress, Physiological
  • Models, Biological
  • Likelihood Functions
  • Heat-Shock Response
  • Gerontology
  • Caenorhabditis elegans
  • Animals
  • Aging
  • Adaptation, Physiological
  • 3202 Clinical sciences