Current Appointments & Affiliations
Research Professor in the Social Science Research Institute
·
2011 - Present
Social Science Research Institute,
University Institutes and Centers
Co-Director of the Biodemography of Aging Research Unit within DUPRI
·
2014 - Present
Center for Population Health & Aging,
Duke Population Research Institute
Member of the Duke Cancer Institute
·
1992 - Present
Duke Cancer Institute,
Institutes and Centers
Faculty Research Scholar of DuPRI's Population Research Center
·
2010 - Present
Duke Population Research Center,
Duke Population Research Institute
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
·
2011 - Present
Center for Population Health & Aging,
Duke Population Research Institute
Recent Publications
Evidence of a novel gene locus <i>ARHGAP44</i> for longitudinal change in hemoglobin A1c levels among subjects without diabetes from the Long Life Family Study.
Journal Article Physiological genomics · May 2025 Glycated hemoglobin A1c (HbA1c) indicates average glucose levels over 3 mo and is associated with insulin resistance and type 2 diabetes (T2D). Longitudinal change in circulating HbA1c (ΔHbA1c) is also associated with aging processes, cognitive performance ... Full text CiteBasic Science and Pathogenesis
Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2024 BACKGROUND: Results of recent analyses indicate that axon demyelination may play an important role in AD pathology. The MBP gene encodes a myelin basic protein involved in axon myelination in the nervous system including the central nervous system. Polymor ... Full text CiteWhole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease.
Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · April 2024 IntroductionLate-onset Alzheimer's disease (LOAD) has a strong genetic component. Participants in Long-Life Family Study (LLFS) exhibit delayed onset of dementia, offering a unique opportunity to investigate LOAD genetics.MethodsWe conduc ... Full text CiteRecent Grants
The Long Life Family Study
ResearchPrincipal Investigator · Awarded by Washington University in St. Louis · 2019 - 2030Leveraging population-based human data to uncover mechanisms connecting Alzheimer's disease and common infections and facilitate vaccines repurposing for AD prevention
ResearchSenior Investigator · Awarded by National Institutes of Health · 2021 - 2027Genetic Modulations of Morbidity Compression: A Population-Based Study
ResearchSenior Investigator · Awarded by National Institute on Aging · 2020 - 2026View All Grants
Education
Moscow Institute of Physics and Technology (Russia) ·
1970
Ph.D.
Moscow Institute of Physics and Technology (Russia) ·
1967
M.S.