Anatoli I. Yashin

Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2024 BACKGROUND: Results of recent analyses indicate that axon demyelination may play an important role in AD pathology. The MBP gene encodes a myelin basic protein involved in axon myelination in the nervous system including the central nervous system. Polymor ... Full text Cite

Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease.

Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · April 2024 IntroductionLate-onset Alzheimer's disease (LOAD) has a strong genetic component. Participants in Long-Life Family Study (LLFS) exhibit delayed onset of dementia, offering a unique opportunity to investigate LOAD genetics.MethodsWe conduc ... Full text Cite

Assessing tilavonemab efficacy in early Alzheimer's disease via longitudinal item response theory modeling.

Journal Article Alzheimers Dement (N Y) · 2024 INTRODUCTION: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by declines in cognitive and functional severities. This research utilized the Clinical Dementia Rating (CDR) to assess the influence of tilavonemab on these deterioration ... Full text Open Access Link to item Cite

Decomposition of disparities in life expectancy with applications to administrative health claims and registry data.

Journal Article Theoretical population biology · October 2023 Research shows that geographic disparities in life expectancy between leading and lagging states are increasing over time while racial disparities between Black and White Americans have been going down. In the 65+ age strata morbidity is the most common ca ... Full text Cite

Mosaic Chromosomal Alterations and Human Longevity.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · August 2023 Mosaic chromosomal alterations (mCAs) are structural alterations associated with aging, cancer, cardiovascular disease, infectious diseases, and mortality. The distribution of mCAs in centenarians and individuals with familial longevity is poorly understoo ... Full text Cite

Forecasting prevalence and mortality of Alzheimer's disease using the partitioning models.

Journal Article Exp Gerontol · April 2023 OBJECTIVES: Health forecasting is an important aspect of ensuring that the health system can effectively respond to the changing epidemiological environment. Common models for forecasting Alzheimer's disease and related dementias (AD/ADRD) are based on sim ... Full text Link to item Cite

Underlying mechanisms of change in cancer prevalence in older U.S. adults: contributions of incidence, survival, and ascertainment at early stages.

Journal Article Cancer Causes Control · September 2022 PURPOSE: To quantitatively evaluate contributions of trends in incidence, relative survival, and stage at diagnosis to the dynamics in the prevalence of major cancers (lung, prostate, colon, breast, urinary bladder, ovaries, stomach, pancreas, esophagus, k ... Full text Open Access Link to item Cite

A comparison of genetic imputation methods using Long Life Family Study genotypes and sequence data with the 1000 Genome reference panel

Journal Article International Journal of Bioinformatics Research and Applications · January 1, 2020 This study compares methods of imputing genetic markers, given a typed GWAS scaffold from the Long Life Family Study (LLFS) and latest reference panel of 1000-Genomes. We examined two programs for pre-phasing haplotypes MACH/SHAPEIT2 and MINIMAC/IMPUTE2 fo ... Full text Cite

A forecasting model of disease prevalence based on the McKendrick-von Foerster equation.

Journal Article Math Biosci · May 2019 A new model for disease prevalence based on the analytical solutions of McKendric-von Foerster's partial differential equations is developed. Derivation of the model and methods to cross check obtained results are explicitly demonstrated. Obtained equation ... Full text Link to item Cite

Study of the bivariate survival data using frailty models based on Lévy processes

Journal Article AStA Advances in Statistical Analysis · March 1, 2019 Frailty models allow us to take into account the non-observable inhomogeneity of individual hazard functions. Although models with time-independent frailty have been intensively studied over the last decades and a wide range of applications in survival ana ... Full text Cite

Genetics of Human Longevity From Incomplete Data: New Findings From the Long Life Family Study.

Journal Article The journals of gerontology. Series A, Biological sciences and medical sciences · October 2018 The special design of the Long Life Family Study provides a unique opportunity to investigate the genetics of human longevity by analyzing data on exceptional lifespans in families. In this article, we performed two series of genome wide association studie ... Full text Cite

Time trends in the prevalence of cancer and non-cancer diseases among older U.S. adults: Medicare-based analysis.

Journal Article Exp Gerontol · September 2018 Longer lifespan is accompanied by a larger number of chronic diseases among older adults. Because of a growing proportion of older adults in the U.S., this brings the problem of age-related morbidity to the forefront as a major contributor to rising medica ... Full text Link to item Cite

Impact of demography and population dynamics on the genetic architecture of human longevity.

Journal Article Aging · August 2018 The study of the genetics of longevity has been mainly addressed by GWASs that considered subjects from different populations to reach higher statistical power. The "price to pay" is that population-specific evolutionary histories and trade-offs were negle ... Full text Cite

Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study.

Journal Article Experimental gerontology · July 2018 BackgroundsElucidating the causal effects of common intermediate risk factors on the onset of age-related diseases is indispensable for developing prevention and intervention procedures.MethodsWe conducted two-stage time-to-event Mendelia ... Full text Cite

Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.

Journal Article Experimental gerontology · July 2018 Despite evident success in clarifying many important features of Alzheimer's disease (AD) the efficient methods of its prevention and treatment are not yet available. The reasons are likely to be the fact that AD is a multifactorial and heterogeneous healt ... Full text Cite

Identifying the causes of the changes in the prevalence patterns of diabetes in older U.S. adults: A new trend partitioning approach.

Journal Article J Diabetes Complications · April 2018 AIMS: To identify how efforts to control the diabetes epidemic and the resulting changes in diabetes mellitus, type II (T2D) incidence and survival have affected the time-trend of T2D prevalence. METHODS: A newly developed method of trend decomposition was ... Full text Link to item Cite

Mortality and Macrovascular Risk in Elderly With Hypertension and Diabetes: Effect of Intensive Drug Therapy.

Journal Article Am J Hypertens · January 12, 2018 BACKGROUND: This study identifies the effect of intensive drug therapy (IDT) in individuals age 65+ with diabetes (type 2 diabetes mellitus (T2D)) and hypertension on all-cause death, congestive heart failure (CHF), hospitalization for myocardial infarctio ... Full text Link to item Cite

Time Trends in the Prevalence of Neurocognitive Disorders and Cognitive Impairment in the United States: The Effects of Disease Severity and Improved Ascertainment.

Journal Article J Alzheimers Dis · 2018 BACKGROUND: Trends in the prevalence of cognitive impairment (CI) based on cognitive assessment instruments are often inconsistent with those of neurocognitive disorders (ND) based on Medicare claims records. OBJECTIVE: We hypothesized that improved ascert ... Full text Link to item Cite

A genetic stochastic process model for genome-wide joint analysis of biomarker dynamics and disease susceptibility with longitudinal data.

Journal Article Genetic epidemiology · November 2017 Unraveling the underlying biological mechanisms or pathways behind the effects of genetic variations on complex diseases remains one of the major challenges in the post-GWAS (where GWAS is genome-wide association study) era. To further explore the relation ... Full text Cite

rqt: an R package for gene-level meta-analysis.

Journal Article Bioinformatics (Oxford, England) · October 2017 MotivationDespite recent advances of modern GWAS methods, it is still remains an important problem of addressing calculation an effect size and corresponding p-value for the whole gene rather than for single variant.ResultsWe developed an ... Full text Cite