Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging.
Publication
, Journal Article
Popovich, IG; Zabezhinskii, MA; Anisimov, VN; Kovalenko, AL; Petrov, AY; Semenchenko, AV; Yashin, AI
Published in: Bulletin of experimental biology and medicine
December 2003
Treatment of female SAMP-1 mice with Neuronol (drug containing succinic acid) given with drinking water starting from the age of 2 months during the whole life prolonged the lifespan and markedly reduced mortality of animals aged 1.5-2 years. Neuronol inhibited the development of spontaneous tumors, primarily lymphomas, and significantly prolonged lifespan in mice with tumors. Long-term treatment with Neuronol had no pathological side effects. Our experiments demonstrated geroprotective and anticarcinogenic activity of Neuronol and safety of its long-term use.
Duke Scholars
Published In
Bulletin of experimental biology and medicine
DOI
EISSN
1573-8221
ISSN
0007-4888
Publication Date
December 2003
Volume
136
Issue
6
Start / End Page
595 / 598
Related Subject Headings
- Succinic Acid
- Succinates
- Neurology & Neurosurgery
- Neoplasms, Experimental
- Mice, Inbred Strains
- Mice
- Lymphoma
- Longevity
- Histiocytoma, Benign Fibrous
- Female
Citation
APA
Chicago
ICMJE
MLA
NLM
Popovich, I. G., Zabezhinskii, M. A., Anisimov, V. N., Kovalenko, A. L., Petrov, A. Y., Semenchenko, A. V., & Yashin, A. I. (2003). Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging. Bulletin of Experimental Biology and Medicine, 136(6), 595–598. https://doi.org/10.1023/b:bebm.0000020214.47787.12
Popovich, I. G., M. A. Zabezhinskii, V. N. Anisimov, A. L. Kovalenko, A Yu Petrov, A. V. Semenchenko, and A. I. Yashin. “Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging.” Bulletin of Experimental Biology and Medicine 136, no. 6 (December 2003): 595–98. https://doi.org/10.1023/b:bebm.0000020214.47787.12.
Popovich IG, Zabezhinskii MA, Anisimov VN, Kovalenko AL, Petrov AY, Semenchenko AV, et al. Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging. Bulletin of experimental biology and medicine. 2003 Dec;136(6):595–8.
Popovich, I. G., et al. “Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging.” Bulletin of Experimental Biology and Medicine, vol. 136, no. 6, Dec. 2003, pp. 595–98. Epmc, doi:10.1023/b:bebm.0000020214.47787.12.
Popovich IG, Zabezhinskii MA, Anisimov VN, Kovalenko AL, Petrov AY, Semenchenko AV, Yashin AI. Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging. Bulletin of experimental biology and medicine. 2003 Dec;136(6):595–598.
Published In
Bulletin of experimental biology and medicine
DOI
EISSN
1573-8221
ISSN
0007-4888
Publication Date
December 2003
Volume
136
Issue
6
Start / End Page
595 / 598
Related Subject Headings
- Succinic Acid
- Succinates
- Neurology & Neurosurgery
- Neoplasms, Experimental
- Mice, Inbred Strains
- Mice
- Lymphoma
- Longevity
- Histiocytoma, Benign Fibrous
- Female