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Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts.

Publication ,  Journal Article
Akushevich, IV; Veremeyeva, GA; Dimov, GP; Ukraintseva, SV; Arbeev, KG; Akleyev, AV; Yashin, AI
Published in: Health physics
September 2010

A new model of the hematopoietic system for humans chronically exposed to ionizing radiation allows for quantitative description of the initial hematopoiesis inhibition and subsequent increase in the risks of late stochastic effects such as leukemia. This model describes the dynamics of the hematopoietic stem cell compartment as well as the dynamics of each of the three blood cell types (leukocytes, erythrocytes, and platelets). The model parameters are estimated from the results of other experiments. They include the steady-state numbers of hematopoietic stem cells and peripheral blood cell lines for an unexposed organism, amplification parameters for each blood cell line, parameters describing the proliferation and apoptosis, parameters of feedback functions regulating the steady-state numbers, and characteristics of radiosensitivity in respect to cell death and non-lethal cell damages. The dynamic model of hematopoiesis is applied to the data on a subcohort of the Techa River residents with hematological measurements (e.g., blood counts) performed in 1950-1956 (which totals to about 3,500 exposed individuals). Among well-described effects observed in these data are the slope values of the dose-effect curves describing the hematopoietic inhibition and the dose rate patterns of the fractions of cytopenic states (e.g., leukopenia, thrombocytopenia). The model has been further generalized by inclusion of the component describing the risk of late stochastic effects. The risks of the development of late effects (such as leukemia) in population groups with specific patterns of early reactions in hematopoiesis (such as leukopenia induced by ionizing radiation) are investigated using simulation studies and compared to data.

Duke Scholars

Published In

Health physics

DOI

EISSN

1538-5159

ISSN

0017-9078

Publication Date

September 2010

Volume

99

Issue

3

Start / End Page

322 / 329

Related Subject Headings

  • Time Factors
  • Stochastic Processes
  • Radiation, Ionizing
  • Population Groups
  • Nuclear Medicine & Medical Imaging
  • Mutagenesis
  • Models, Biological
  • Leukocytes
  • Humans
  • Hematopoietic System
 

Citation

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Akushevich, I. V., Veremeyeva, G. A., Dimov, G. P., Ukraintseva, S. V., Arbeev, K. G., Akleyev, A. V., & Yashin, A. I. (2010). Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts. Health Physics, 99(3), 322–329. https://doi.org/10.1097/hp.0b013e3181c61dc1
Akushevich, Igor V., Galina A. Veremeyeva, Georgy P. Dimov, Svetlana V. Ukraintseva, Konstantin G. Arbeev, Alexander V. Akleyev, and Anatoly I. Yashin. “Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts.Health Physics 99, no. 3 (September 2010): 322–29. https://doi.org/10.1097/hp.0b013e3181c61dc1.
Akushevich IV, Veremeyeva GA, Dimov GP, Ukraintseva SV, Arbeev KG, Akleyev AV, et al. Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts. Health physics. 2010 Sep;99(3):322–9.
Akushevich, Igor V., et al. “Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts.Health Physics, vol. 99, no. 3, Sept. 2010, pp. 322–29. Epmc, doi:10.1097/hp.0b013e3181c61dc1.
Akushevich IV, Veremeyeva GA, Dimov GP, Ukraintseva SV, Arbeev KG, Akleyev AV, Yashin AI. Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts. Health physics. 2010 Sep;99(3):322–329.

Published In

Health physics

DOI

EISSN

1538-5159

ISSN

0017-9078

Publication Date

September 2010

Volume

99

Issue

3

Start / End Page

322 / 329

Related Subject Headings

  • Time Factors
  • Stochastic Processes
  • Radiation, Ionizing
  • Population Groups
  • Nuclear Medicine & Medical Imaging
  • Mutagenesis
  • Models, Biological
  • Leukocytes
  • Humans
  • Hematopoietic System