Overview
Konstantin G. Arbeev received the M.S. degree in Applied Mathematics from Moscow State University (branch in Ulyanovsk, Russia) in 1995 and the Ph.D. degree in Mathematics and Physics (specialization in Theoretical Foundations of Mathematical Modeling, Numerical Methods and Programming) from Ulyanovsk State University (Russia) in 1999. He was a post-doctoral fellow in Max Planck Institute for Demographic Research in Rostock (Germany) before moving to Duke University in 2004 to work as a Research Scientist and a Senior Research Scientist in the Department of Sociology and the Social Science Research Institute (SSRI). He is currently an Associate Research Professor in SSRI. Dr. Arbeev's major research interests are related to three interconnected fields of biodemography, biostatistics and genetic epidemiology as pertains to research on aging. The focus of his research is on discovering genetic and non-genetic factors that can affect the process of aging and determine longevity and healthy lifespan. He is interested in both methodological advances in this research area as well as their practical applications to analyses of large-scale longitudinal studies with phenotypic, genetic and, recently, genomic information. Dr. Arbeev authored and co-authored more than 150 peer-reviewed publications in these areas.
Current Appointments & Affiliations
Recent Publications
Development of an exact theory of decomposing population attributable fractions and application to decomposition of Alzheimer’s disease risk
Journal Article Mathematical Population Studies · January 1, 2026 A new mathematically exact method of population attributable fraction (PAF) decomposition free of limitations inherent in existing approaches was developed and compared to existing methods based on the Miettinen, Norton, and Niedhammer-Chastang formulae. T ... Full text CiteBasic Science and Pathogenesis.
Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 BackgroundAPOE4 is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), with a higher effect in females than in males. Identifying factors that may reduce the detrimental impact of APOE4 on AD is an important research objecti ... Full text CiteDeveloping Topics.
Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 2025 BackgroundAccumulating evidence points to a major role of compromised immunity in Alzheimer's Disease (AD). The MIR146a and COMT genes are both known for their involvement in immune responses, as well as in AD-related traits. COMT also regulates t ... Full text CiteRecent Grants
The Long Life Family Study
ResearchSenior Investigator · Awarded by Washington University in St. Louis · 2019 - 2030Leveraging population-based human data to uncover mechanisms connecting Alzheimer's disease and common infections and facilitate vaccines repurposing for AD prevention
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2021 - 2026Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic context
ResearchSenior Investigator · Awarded by National Institutes of Health · 2020 - 2026View All Grants