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Konstantin Arbeev

Associate Research Professor in the Social Science Research Institute
Social Science Research Institute
Box 90420, Durham, NC 27708
2024 W. Main Street, Room A102F, Durham, NC 27705

Overview


Konstantin G. Arbeev received the M.S. degree in Applied Mathematics from Moscow State University (branch in Ulyanovsk, Russia) in 1995 and the Ph.D. degree in Mathematics and Physics (specialization in Theoretical Foundations of Mathematical Modeling, Numerical Methods and Programming) from Ulyanovsk State University (Russia) in 1999. He was a post-doctoral fellow in Max Planck Institute for Demographic Research in Rostock (Germany) before moving to Duke University in 2004 to work as a Research Scientist and a Senior Research Scientist in the Department of Sociology and the Social Science Research Institute (SSRI).  He is currently an Associate Research Professor in SSRI. Dr. Arbeev's major research interests are related to three interconnected fields of biodemography, biostatistics and genetic epidemiology as pertains to research on aging. The focus of his research is on discovering genetic and non-genetic factors that can affect the process of aging and determine longevity and healthy lifespan. He is interested in both methodological advances in this research area as well as their practical applications to analyses of large-scale longitudinal studies with phenotypic, genetic and, recently, genomic information. Dr. Arbeev authored and co-authored more than 150 peer-reviewed publications in these areas.

Current Appointments & Affiliations


Associate Research Professor in the Social Science Research Institute · 2017 - Present Social Science Research Institute, University Institutes and Centers

Recent Publications


APOE4 and infectious diseases jointly contribute to brain glucose hypometabolism, a biomarker of Alzheimer's pathology: New findings from the ADNI.

Journal Article PloS one · January 2025 BackgroundImpaired brain glucose metabolism is a preclinical feature of neurodegenerative diseases such as Alzheimer's disease (AD). Infections may promote AD-related pathology. Therefore, we investigated the interplay between infections and APOE4 ... Full text Cite

SNP rs6543176 is associated with extreme human longevity but increased risk for cancer.

Journal Article GeroScience · January 2025 Using whole-genome sequencing (WGS) might offer insights into rare genetic variants associated with healthy aging and extreme longevity (EL), potentially pointing to useful therapeutic targets. In this study, we conducted a genome-wide association study us ... Full text Cite

Basic Science and Pathogenesis

Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2024 BACKGROUND: Results of recent analyses indicate that axon demyelination may play an important role in AD pathology. The MBP gene encodes a myelin basic protein involved in axon myelination in the nervous system including the central nervous system. Polymor ... Full text Cite
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Recent Grants


Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic context

ResearchSenior Investigator · Awarded by National Institutes of Health · 2020 - 2026

Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseases

ResearchSenior Investigator · Awarded by National Institute on Aging · 2020 - 2026

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Education, Training & Certifications


Ulyanovsk State University (Russia) · 1999 Ph.D.