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Opposite phenotypes of cancer and aging arise from alternative regulation of common signaling pathways.

Publication ,  Journal Article
Ukraintseva, SV; Yashin, AI
Published in: Annals of the New York Academy of Sciences
December 2003

Phenotypic features of malignant and senescent cells are in many instances opposite. Cancer cells do not "age"; their metabolic, proliferative, and growth characteristics are opposite to those observed with cellular aging (both replicative and functional). In many such characteristics cancer cells resemble embryonic cells. One can say that cancer manifests itself as a local, uncontrolled "rejuvenation" in an organism. Available evidence from human and animal studies suggests that the opposite phenotypic features of aging and cancer arise from the opposite regulation of genes participating in apoptosis/growth arrest or growth signal transduction pathways in cells. This fact may be applicable in the development of new anti-aging treatments. Genes that are contrarily regulated in cancer and aging cells (e.g., proto-oncogenes or tumor suppressors) could be candidate targets for anti-aging interventions. Their "cancer-like" regulation, if strictly controlled, might help to rejuvenate the human organism.

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Published In

Annals of the New York Academy of Sciences

DOI

EISSN

1749-6632

ISSN

0077-8923

Publication Date

December 2003

Volume

1010

Start / End Page

489 / 492

Related Subject Headings

  • Signal Transduction
  • Phenotype
  • Neoplasms
  • Humans
  • General Science & Technology
  • Cell Survival
  • Apoptosis
  • Animals
  • Aging
 

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Ukraintseva, S. V., & Yashin, A. I. (2003). Opposite phenotypes of cancer and aging arise from alternative regulation of common signaling pathways. Annals of the New York Academy of Sciences, 1010, 489–492. https://doi.org/10.1196/annals.1299.089
Ukraintseva, Svetlana V., and Anatoly I. Yashin. “Opposite phenotypes of cancer and aging arise from alternative regulation of common signaling pathways.Annals of the New York Academy of Sciences 1010 (December 2003): 489–92. https://doi.org/10.1196/annals.1299.089.
Ukraintseva SV, Yashin AI. Opposite phenotypes of cancer and aging arise from alternative regulation of common signaling pathways. Annals of the New York Academy of Sciences. 2003 Dec;1010:489–92.
Ukraintseva, Svetlana V., and Anatoly I. Yashin. “Opposite phenotypes of cancer and aging arise from alternative regulation of common signaling pathways.Annals of the New York Academy of Sciences, vol. 1010, Dec. 2003, pp. 489–92. Epmc, doi:10.1196/annals.1299.089.
Ukraintseva SV, Yashin AI. Opposite phenotypes of cancer and aging arise from alternative regulation of common signaling pathways. Annals of the New York Academy of Sciences. 2003 Dec;1010:489–492.
Journal cover image

Published In

Annals of the New York Academy of Sciences

DOI

EISSN

1749-6632

ISSN

0077-8923

Publication Date

December 2003

Volume

1010

Start / End Page

489 / 492

Related Subject Headings

  • Signal Transduction
  • Phenotype
  • Neoplasms
  • Humans
  • General Science & Technology
  • Cell Survival
  • Apoptosis
  • Animals
  • Aging