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How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data.

Publication ,  Journal Article
Yashin, AI; Arbeev, KG; Wu, D; Arbeeva, LS; Kulminski, A; Akushevich, I; Culminskaya, I; Stallard, E; Ukraintseva, SV
Published in: Frontiers in genetics
January 2013

The influence of genes on human lifespan is mediated by biological processes that characterize body's functioning. The age trajectories of these processes contain important information about mechanisms linking aging, health, and lifespan. The objective of this paper is to investigate regularities of aging changes in different groups of individuals, including individuals with different genetic background, as well as their connections with health and lifespan.To reach this objective we used longitudinal data on four physiological variables, information about health and lifespan collected in the Framingham Heart Study (FHS), data on longevity alleles detected in earlier study, as well as methods of statistical modeling.We found that phenotypes of exceptional longevity and health are linked to distinct types of changes in physiological indices during aging. We also found that components of aging changes differ in groups of individuals with different genetic background.These results suggest that factors responsible for exceptional longevity and health are not necessary the same, and that postponing aging changes is associated with extreme longevity. The genetic factors which increase lifespan are associated with physiological changes typical of healthy and long-living individuals, smaller mortality risks from cancer and CVD and better estimates of adaptive capacity in statistical modeling. This indicates that extreme longevity and health related traits are likely to be less heterogeneous phenotypes than lifespan, and studying these phenotypes separately from lifespan may provide additional information about mechanisms of human aging and its relation to chronic diseases and lifespan.

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Published In

Frontiers in genetics

DOI

EISSN

1664-8021

ISSN

1664-8021

Publication Date

January 2013

Volume

4

Start / End Page

3

Related Subject Headings

  • 3105 Genetics
  • 1801 Law
  • 1103 Clinical Sciences
  • 0604 Genetics
 

Citation

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Chicago
ICMJE
MLA
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Yashin, A. I., Arbeev, K. G., Wu, D., Arbeeva, L. S., Kulminski, A., Akushevich, I., … Ukraintseva, S. V. (2013). How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data. Frontiers in Genetics, 4, 3. https://doi.org/10.3389/fgene.2013.00003
Yashin, Anatoliy I., Konstantin G. Arbeev, Deqing Wu, Liubov S. Arbeeva, Alexander Kulminski, Igor Akushevich, Irina Culminskaya, Eric Stallard, and Svetlana V. Ukraintseva. “How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data.Frontiers in Genetics 4 (January 2013): 3. https://doi.org/10.3389/fgene.2013.00003.
Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Kulminski A, Akushevich I, et al. How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data. Frontiers in genetics. 2013 Jan;4:3.
Yashin, Anatoliy I., et al. “How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data.Frontiers in Genetics, vol. 4, Jan. 2013, p. 3. Epmc, doi:10.3389/fgene.2013.00003.
Yashin AI, Arbeev KG, Wu D, Arbeeva LS, Kulminski A, Akushevich I, Culminskaya I, Stallard E, Ukraintseva SV. How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data. Frontiers in genetics. 2013 Jan;4:3.

Published In

Frontiers in genetics

DOI

EISSN

1664-8021

ISSN

1664-8021

Publication Date

January 2013

Volume

4

Start / End Page

3

Related Subject Headings

  • 3105 Genetics
  • 1801 Law
  • 1103 Clinical Sciences
  • 0604 Genetics