Irina Kulminskaya | Scholars@Duke

Irina Kulminskaya
Research Scientist, Senior

Current Appointments & Affiliations

Research Scientist, Senior, Center for Population Health & Aging, Duke Population Research Institute

Contact Information

2024 W Main Street, Erwin Mill Building, Durham, NC 27708
irina.kulminskaya@duke.edu +1 919 681 8232

Research
Selected Grants
- Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic context awarded by National Institutes of Health 2020 - 2025
- Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseases awarded by National Institutes of Health 2020 - 2025
- ApoE2 and protective molecular signatures in Alzheimer's disease and aging awarded by National Institutes of Health 2018 - 2023
- Life Course and Genetic and Non-genetic Factors in Health and Survival awarded by National Institutes of Health 2015 - 2021
- Evaluating New Genetic Effects on Health and Aging from Longitudinal Data awarded by National Institutes of Health 2007 - 2013
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Kulminski, Alexander M., Ian Philipp, Leonardo Shu, and Irina Culminskaya. “Definitive roles of TOMM40-APOE-APOC1 variants in the Alzheimer's risk. (Accepted)” Neurobiology of Aging 110 (February 2022): 122–31. https://doi.org/10.1016/j.neurobiolaging.2021.09.009.
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  - Nazarian, Alireza, Yury Loika, Liang He, Irina Culminskaya, and Alexander M. Kulminski. “Genome-wide analysis identified abundant genetic modulators of contributions of the apolipoprotein E alleles to Alzheimer's disease risk.” Alzheimer’S & Dementia : The Journal of the Alzheimer’S Association, January 3, 2022. https://doi.org/10.1002/alz.12540.
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  - Kulminski, Alexander M., Elena Loiko, Yury Loika, and Irina Culminskaya. “Pleiotropic predisposition to Alzheimer's disease and educational attainment: insights from the summary statistics analysis.” Geroscience, November 6, 2021. https://doi.org/10.1007/s11357-021-00484-1.
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  - Kulminski, Alexander M., Ian Philipp, Yury Loika, Liang He, and Irina Culminskaya. “Protective association of the ε2/ε3 heterozygote with Alzheimer's disease is strengthened by TOMM40-APOE variants in men.” Alzheimer’S & Dementia : The Journal of the Alzheimer’S Association 17, no. 11 (November 2021): 1779–87. https://doi.org/10.1002/alz.12413.
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  - Loika, Yury, Irina Irincheeva, Irina Culminskaya, Alireza Nazarian, and Alexander M. Kulminski. “Polygenic risk scores: pleiotropy and the effect of environment.” Geroscience 42, no. 6 (December 2020): 1635–47. https://doi.org/10.1007/s11357-020-00203-2.
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  - Kulminski, Alexander M., Yury Loika, Alireza Nazarian, and Irina Culminskaya. “Quantitative and Qualitative Role of Antagonistic Heterogeneity in Genetics of Blood Lipids.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 75, no. 10 (September 2020): 1811–19. https://doi.org/10.1093/gerona/glz225.
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  - Kulminski, Alexander M., Leonardo Shu, Yury Loika, Alireza Nazarian, Konstantin Arbeev, Svetlana Ukraintseva, Anatoliy Yashin, and Irina Culminskaya. “APOE region molecular signatures of Alzheimer's disease across races/ethnicities.” Neurobiology of Aging 87 (March 2020): 141.e1-141.e8. https://doi.org/10.1016/j.neurobiolaging.2019.11.007.
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  - Kulminski, Alexander M., Ian Philipp, Yury Loika, Liang He, and Irina Culminskaya. “Haplotype architecture of the Alzheimer's risk in the APOE region via co-skewness.” Alzheimer’S & Dementia (Amsterdam, Netherlands) 12, no. 1 (January 2020): e12129. https://doi.org/10.1002/dad2.12129.
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  - Kulminski, Alexander M., Leonardo Shu, Yury Loika, Liang He, Alireza Nazarian, Konstantin Arbeev, Svetlana Ukraintseva, Anatoliy Yashin, and Irina Culminskaya. “Genetic and regulatory architecture of Alzheimer's disease in the APOE region.” Alzheimer’S & Dementia (Amsterdam, Netherlands) 12, no. 1 (January 2020): e12008. https://doi.org/10.1002/dad2.12008.
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  - Kulminski, Alexander M., Chansuk Kang, Stanislav A. Kolpakov, Yury Loika, Alireza Nazarian, Anatoliy I. Yashin, Eric Stallard, and Irina Culminskaya. “Polygenic risk score for disability and insights into disability-related molecular mechanisms.” Geroscience 41, no. 6 (December 2019): 881–93. https://doi.org/10.1007/s11357-019-00125-8.
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  - Kulminski, Alexander M., Yury Loika, Irina Culminskaya, Jian Huang, Konstantin G. Arbeev, Olivia Bagley, Mary F. Feitosa, et al. “Independent associations of TOMM40 and APOE variants with body mass index.” Aging Cell 18, no. 1 (February 2019): e12869. https://doi.org/10.1111/acel.12869.
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  - Kulminski, Alexander M., Yury Loika, Jian Huang, Konstantin G. Arbeev, Olivia Bagley, Svetlana Ukraintseva, Anatoliy I. Yashin, and Irina Culminskaya. “Pleiotropic Meta-Analysis of Age-Related Phenotypes Addressing Evolutionary Uncertainty in Their Molecular Mechanisms.” Frontiers in Genetics 10 (January 2019): 433. https://doi.org/10.3389/fgene.2019.00433.
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  - Kulminski, Alexander M., Jian Huang, Jiayi Wang, Liang He, Yury Loika, and Irina Culminskaya. “Apolipoprotein E region molecular signatures of Alzheimer's disease.” Aging Cell 17, no. 4 (August 2018): e12779. https://doi.org/10.1111/acel.12779.
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  - He, Liang, Irina Culminskaya, Yury Loika, Konstantin G. Arbeev, Olivia Bagley, Matt Duan, Anatoliy I. Yashin, and Alexander M. Kulminski. “Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study.” Experimental Gerontology 107 (July 2018): 74–86. https://doi.org/10.1016/j.exger.2017.09.019.
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  - Yashin, Anatoliy I., Fang Fang, Mikhail Kovtun, Deqing Wu, Matt Duan, Konstantin Arbeev, Igor Akushevich, et al. “Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses.” Experimental Gerontology 107 (July 2018): 148–60. https://doi.org/10.1016/j.exger.2017.10.020.
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  - Kulminski, Alexander M., Jian Huang, Yury Loika, Konstantin G. Arbeev, Olivia Bagley, Arseniy Yashkin, Matt Duan, and Irina Culminskaya. “Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes.” Aging 10, no. 3 (March 2018): 492–514. https://doi.org/10.18632/aging.101407.
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  - Kulminski, Alexander M., Yelena Kernogitski, Irina Culminskaya, Yury Loika, Konstantin G. Arbeev, Olivia Bagley, Matt Duan, et al. “Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits.” Aging Cell 16, no. 1 (February 2017): 61–72. https://doi.org/10.1111/acel.12526.
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  - He, Liang, Yelena Kernogitski, Irina Kulminskaya, Yury Loika, Konstantin G. Arbeev, Elena Loiko, Olivia Bagley, et al. “Corrigendum: Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.” Frontiers in Genetics 8 (January 2017): 226. https://doi.org/10.3389/fgene.2017.00226.
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  - Kulminski, Alexander M., Liang He, Irina Culminskaya, Yury Loika, Yelena Kernogitski, Konstantin G. Arbeev, Elena Loiko, et al. “Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality.” Plos Genetics 12, no. 11 (November 10, 2016): e1006314. https://doi.org/10.1371/journal.pgen.1006314.
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  - Kulminski, Alexander M., Nalini Raghavachari, Konstantin G. Arbeev, Irina Culminskaya, Liubov Arbeeva, Deqing Wu, Svetlana V. Ukraintseva, Kaare Christensen, and Anatoliy I. Yashin. “Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study.” Biogerontology 17, no. 5–6 (November 2016): 893–905. https://doi.org/10.1007/s10522-016-9659-3.
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  - Kulminski, Alexander M., Yury Loika, Irina Culminskaya, Konstantin G. Arbeev, Svetlana V. Ukraintseva, Eric Stallard, and Anatoliy I. Yashin. “Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency.” Scientific Reports 6 (October 14, 2016): 35390. https://doi.org/10.1038/srep35390.
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  - Yashin, Anatoliy I., Konstantin G. Arbeev, Liubov S. Arbeeva, Deqing Wu, Igor Akushevich, Mikhail Kovtun, Arseniy Yashkin, et al. “How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity.” Biogerontology 17, no. 1 (February 2016): 89–107. https://doi.org/10.1007/s10522-015-9594-8.
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  - He, Liang, Yelena Kernogitski, Irina Kulminskaya, Yury Loika, Konstantin G. Arbeev, Elena Loiko, Olivia Bagley, et al. “Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.” Frontiers in Genetics 7 (January 2016): 179. https://doi.org/10.3389/fgene.2016.00179.
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  - Yashin, Anatoliy I., Ilya Zhbannikov, Liubov Arbeeva, Konstantin G. Arbeev, Deqing Wu, Igor Akushevich, Arseniy Yashkin, et al. “Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures.” Frontiers in Genetics 7 (January 2016): 188. https://doi.org/10.3389/fgene.2016.00188.
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  - Yashin, Anatoliy I., Konstantin G. Arbeev, Deqing Wu, Liubov Arbeeva, Alexander Kulminski, Irina Kulminskaya, Igor Akushevich, and Svetlana V. Ukraintseva. “How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data.” North American Actuarial Journal : Naaj 20, no. 3 (January 2016): 201–32. https://doi.org/10.1080/10920277.2016.1178588.
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  - Kulminski, Alexander M., Konstantin G. Arbeev, Irina Culminskaya, Svetlana V. Ukraintseva, Eric Stallard, Michael A. Province, and Anatoli I. Yashin. “Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study.” Rejuvenation Research 18, no. 2 (April 2015): 128–35. https://doi.org/10.1089/rej.2014.1616.
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  - Kulminski, Alexander M., Irina Culminskaya, Konstantin G. Arbeev, Liubov Arbeeva, Svetlana V. Ukraintseva, Eric Stallard, Deqing Wu, and Anatoliy I. Yashin. “Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.” Plos One 10, no. 8 (January 2015): e0136319. https://doi.org/10.1371/journal.pone.0136319.
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  - Yashin, Anatoliy I., Deqing Wu, Liubov S. Arbeeva, Konstantin G. Arbeev, Alexander M. Kulminski, Igor Akushevich, Mikhail Kovtun, et al. “Genetics of aging, health, and survival: dynamic regulation of human longevity related traits.” Frontiers in Genetics 6 (January 2015): 122. https://doi.org/10.3389/fgene.2015.00122.
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  - Kulminski, Alexander, Irina Culminskaya, and Anatoli I. Yashin. “Letter to the editor: Standardization of genetic association studies, pros and cons, reaffirmed.” Age (Dordrecht, Netherlands) 36, no. 2 (April 2014): 945–47. https://doi.org/10.1007/s11357-013-9602-3.
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  - Kulminski, A. M., K. G. Arbeev, I. Culminskaya, L. Arbeeva, S. V. Ukraintseva, E. Stallard, K. Christensen, N. Schupf, M. A. Province, and A. I. Yashin. “Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan.” Plos Genetics 10, no. 1 (January 1, 2014). https://doi.org/10.1371/journal.pgen.1004141.
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  - Kulminski, Alexander M., Irina Culminskaya, Konstantin G. Arbeev, Svetlana V. Ukraintseva, Eric Stallard, Liubov Arbeeva, and Anatoli I. Yashin. “The role of lipid-related genes, aging-related processes, and environment in healthspan.” Aging Cell 12, no. 2 (April 2013): 237–46. https://doi.org/10.1111/acel.12046.
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  - Kulminski, Alexander M., Irina Culminskaya, and Anatoli I. Yashin. “Inter-chromosomal level of genome organization and longevity-related phenotypes in humans.” Age (Dordrecht, Netherlands) 35, no. 2 (April 2013): 501–18. https://doi.org/10.1007/s11357-011-9374-6.
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  - Kulminski, Alexander M., and Irina Culminskaya. “Genomics of human health and aging.” Age (Dordrecht, Netherlands) 35, no. 2 (April 2013): 455–69. https://doi.org/10.1007/s11357-011-9362-x.
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  - Kulminski, Alexander M., Irina Culminskaya, Konstantin G. Arbeev, Svetlana V. Ukraintseva, Liubov Arbeeva, and Anatoli I. Yashin. “Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations.” Rejuvenation Research 16, no. 1 (February 2013): 28–34. https://doi.org/10.1089/rej.2012.1362.
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  - Yashin, Anatoliy I., Konstantin G. Arbeev, Deqing Wu, Liubov S. Arbeeva, Alexander Kulminski, Igor Akushevich, Irina Culminskaya, Eric Stallard, and Svetlana V. Ukraintseva. “How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data.” Frontiers in Genetics 4 (January 22, 2013): 3. https://doi.org/10.3389/fgene.2013.00003.
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  - Yashin, Anatoliy I., Konstantin G. Arbeev, Deqing Wu, Liubov S. Arbeeva, Alexander M. Kulminski, Igor Akushevich, Irina Culminskaya, Eric Stallard, and Svetlana V. Ukraintseva. “How the quality of GWAS of human lifespan and health span can be improved.” Frontiers in Genetics 4 (January 2013): 125. https://doi.org/10.3389/fgene.2013.00125.
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  - Kulminski, Alexander M., Irina Culminskaya, Svetlana V. Ukraintseva, Konstantin G. Arbeev, Liubov Arbeeva, Deqing Wu, Igor Akushevich, Kenneth C. Land, and Anatoli I. Yashin. “Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan.” Aging Cell 10, no. 3 (June 2011): 533–41. https://doi.org/10.1111/j.1474-9726.2011.00689.x.
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  - Arbeev, Konstantin G., Svetlana V. Ukraintseva, Igor Akushevich, Alexander M. Kulminski, Liubov S. Arbeeva, Lucy Akushevich, Irina V. Culminskaya, and Anatoliy I. Yashin. “Age trajectories of physiological indices in relation to healthy life course.” Mechanisms of Ageing and Development 132, no. 3 (March 2011): 93–102. https://doi.org/10.1016/j.mad.2011.01.001.
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  - Ukraintseva, Svetlana V., Konstantin G. Arbeev, Igor Akushevich, Alexander Kulminski, Liubov Arbeeva, Irina Culminskaya, Lucy Akushevich, and Anatoli I. Yashin. “Trade-offs between cancer and other diseases: do they exist and influence longevity?” Rejuvenation Research 13, no. 4 (August 2010): 387–96. https://doi.org/10.1089/rej.2009.0941.
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  - Yashin, Anatoli I., Konstantin G. Arbeev, Igor Akushevich, Svetlana V. Ukraintseva, Alexander Kulminski, Liubov S. Arbeeva, and Irina Culminskaya. “Exceptional survivors have lower age trajectories of blood glucose: lessons from longitudinal data.” Biogerontology 11, no. 3 (June 2010): 257–65. https://doi.org/10.1007/s10522-009-9243-1.
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  - Kulminski, Alexander M., Irina Culminskaya, Svetlana V. Ukraintseva, Konstantin G. Arbeev, Kenneth C. Land, and Anatoli I. Yashin. “Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context.” Mechanisms of Ageing and Development 131, no. 5 (May 2010): 338–45. https://doi.org/10.1016/j.mad.2010.04.001.
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  - Kulminski, Alexander M., Irina V. Culminskaya, Svetlana V. Ukraintseva, Konstantin G. Arbeev, Igor Akushevich, Kenneth C. Land, and Anatoli I. Yashin. “Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction.” Rejuvenation Research 13, no. 1 (February 2010): 13–21. https://doi.org/10.1089/rej.2009.0905.
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  - Yashin, Anatoli I., Konstantin G. Arbeev, Igor Akushevich, Liubov Arbeeva, Julia Kravchenko, Dora Il’yasova, Alexander Kulminski, et al. “Dynamic determinants of longevity and exceptional health.” Curr Gerontol Geriatr Res, 2010. https://doi.org/10.1155/2010/381637.
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  - Kulminski, Alexander M., Freerk Molleman, Irina V. Culminskaya, Konstantin G. Arbeev, Svetlana V. Ukraintseva, James R. Carey, and Anatoli I. Yashin. “Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens.” Experimental Gerontology 44, no. 11 (November 2009): 718–26. https://doi.org/10.1016/j.exger.2009.08.007.
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  - Arbeev, Konstantin G., Igor Akushevich, Alexander M. Kulminski, Liubov S. Arbeeva, Lucy Akushevich, Svetlana V. Ukraintseva, Irina V. Culminskaya, and Anatoli I. Yashin. “Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete data.” Journal of Theoretical Biology 258, no. 1 (May 2009): 103–11. https://doi.org/10.1016/j.jtbi.2009.01.023.
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  - Kulminski, Alexander M., Konstantin G. Arbeev, Irina V. Culminskaya, Svetlana V. Ukraintseva, Kaare Christensen, and Anatoli I. Yashin. “Health-related phenotypes and longevity in danish twins.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 64, no. 1 (January 2009): 1–8. https://doi.org/10.1093/gerona/gln051.
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  - Shimko, V. E., I. V. Kulminskaya, L. N. Kalitukho, and I. A. Gordei. “Comparative analysis of photosynthetic characteristics and productivity in F2 hybrids of winter rye.” Russian Journal of Plant Physiology 56, no. 1 (January 1, 2009): 126–32. https://doi.org/10.1134/S102144370901018X.
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  - Kulminski, Alexander M., Irina V. Culminskaya, Svetlana V. Ukraintseva, Konstantin G. Arbeev, Kenneth C. Land, and Anatoli I. Yashin. “Sex-specific health deterioration and mortality: the morbidity-mortality paradox over age and time.” Experimental Gerontology 43, no. 12 (December 2008): 1052–57. https://doi.org/10.1016/j.exger.2008.09.007.
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  - Kulminski, Alexander M., Svetlana V. Ukraintseva, Irina V. Culminskaya, Konstantin G. Arbeev, Kenneth C. Land, Lucy Akushevich, and Anatoli I. Yashin. “Cumulative deficits and physiological indices as predictors of mortality and long life.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 63, no. 10 (October 2008): 1053–59. https://doi.org/10.1093/gerona/63.10.1053.
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  - Kulminski, Alexander M., Konstantin G. Arbeev, Svetlana V. Ukraintseva, Irina V. Culminskaya, Kenneth Land, and Anatoli I. Yashin. “Changes in health status among participants of the Framingham Heart Study from the 1960s to the 1990s: application of an index of cumulative deficits.” Annals of Epidemiology 18, no. 9 (September 2008): 696–701. https://doi.org/10.1016/j.annepidem.2008.06.005.
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  - Kulminski, Alexander M., Svetlana V. Ukraintseva, Irina V. Kulminskaya, Konstantin G. Arbeev, Kenneth Land, and Anatoli I. Yashin. “Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study.” Journal of the American Geriatrics Society 56, no. 5 (May 2008): 898–903. https://doi.org/10.1111/j.1532-5415.2008.01656.x.
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  - Kulminski, Alexander M., Irina V. Kulminskaya, Svetlana V. Ukraintseva, Kenneth Land, and Anatoli I. Yashin. “An inverse association between self-reported arthritis and mortality in the elderly: findings from the national long-term care survey.” Rejuvenation Research 11, no. 1 (February 2008): 251–57. https://doi.org/10.1089/rej.2007.0611.
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  - Kulminski, Alexander M., Konstantin G. Arbeev, Irina V. Kulminskaya, Svetlana V. Ukraintseva, Kenneth Land, Igor Akushevich, and Anatoli I. Yashin. “Body mass index and nine-year mortality in disabled and nondisabled older U.S. individuals.” Journal of the American Geriatrics Society 56, no. 1 (January 2008): 105–10. https://doi.org/10.1111/j.1532-5415.2007.01494.x.
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Selected Grants

Selected Publications

Academic Articles