Irina Kulminskaya | Scholars@Duke

Irina Kulminskaya
Research Scientist, Senior

Current Appointments & Affiliations

Research Scientist, Senior, Center for Population Health & Aging, Duke Population Research Institute

Contact Information

2024 W Main Street, Erwin Mill Building, Durham, NC 27708
irina.kulminskaya@duke.edu +1 919 681 8232

Research
Selected Grants
- ApoE2 and protective molecular signatures in Alzheimer's disease and aging awarded by National Institutes of Health 2018 - 2023
- Life Course and Genetic and Non-genetic Factors in Health and Survival awarded by National Institutes of Health 2015 - 2020
- Evaluating New Genetic Effects on Health and Aging from Longitudinal Data awarded by National Institutes of Health 2007 - 2013
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Kulminski, AM, Huang, J, Wang, J, He, L, Loika, Y, and Culminskaya, I. "Apolipoprotein E region molecular signatures of Alzheimer's disease." Aging Cell (May 23, 2018): e12779-null. Full Text
  - Kulminski, AM, Huang, J, Loika, Y, Arbeev, KG, Bagley, O, Yashkin, A, Duan, M, and Culminskaya, I. "Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes." Aging 10, no. 3 (March 2018): 492-514. Full Text
  - Yashin, AI, Fang, F, Kovtun, M, Wu, D, Duan, M, Arbeev, K, Akushevich, I, Kulminski, A, Culminskaya, I, Zhbannikov, I, Yashkin, A, Stallard, E, and Ukraintseva, S. "Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses." Experimental gerontology (October 26, 2017). Full Text
  - He, L, Culminskaya, I, Loika, Y, Arbeev, KG, Bagley, O, Duan, M, Yashin, AI, and Kulminski, AM. "Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study." Experimental gerontology (September 27, 2017). Full Text
  - Kulminski, AM, Kernogitski, Y, Culminskaya, I, Loika, Y, Arbeev, KG, Bagley, O, Duan, M, Arbeeva, L, Ukraintseva, SV, Wu, D, Stallard, E, and Yashin, AI. "Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits." Aging cell 16, no. 1 (February 2017): 61-72. Full Text Open Access Copy
  - He, L, Kernogitski, Y, Kulminskaya, I, Loika, Y, Arbeev, KG, Loiko, E, Bagley, O, Duan, M, Yashkin, A, Ukraintseva, SV, Kovtun, M, Yashin, AI, and Kulminski, AM. "Corrigendum: Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases." Frontiers in Genetics 8 (January 2017): 226-null. Full Text
  - Kulminski, AM, He, L, Culminskaya, I, Loika, Y, Kernogitski, Y, Arbeev, KG, Loiko, E, Arbeeva, L, Bagley, O, Duan, M, Yashkin, A, Fang, F, Kovtun, M, Ukraintseva, SV, Wu, D, and Yashin, AI. "Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality." Plos Genetics 12, no. 11 (November 10, 2016): e1006314-null. Full Text
  - Kulminski, AM, Raghavachari, N, Arbeev, KG, Culminskaya, I, Arbeeva, L, Wu, D, Ukraintseva, SV, Christensen, K, and Yashin, AI. "Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study." Biogerontology 17, no. 5-6 (November 2016): 893-905. Full Text Open Access Copy
  - Kulminski, AM, Loika, Y, Culminskaya, I, Arbeev, KG, Ukraintseva, SV, Stallard, E, and Yashin, AI. "Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency." Scientific reports 6 (October 14, 2016): 35390-. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Arbeeva, LS, Wu, D, Akushevich, I, Kovtun, M, Yashkin, A, Kulminski, A, Culminskaya, I, Stallard, E, Li, M, and Ukraintseva, SV. "How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity." Biogerontology 17, no. 1 (February 2016): 89-107. (Review) Full Text Open Access Copy
  - He, L, Kernogitski, Y, Kulminskaya, I, Loika, Y, Arbeev, KG, Loiko, E, Bagley, O, Duan, M, Yashkin, A, Ukraintseva, SV, Kovtun, M, Yashin, AI, and Kulminski, AM. "Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases." Frontiers in genetics 7 (January 2016): 179-. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Wu, D, Arbeeva, L, Kulminski, A, Kulminskaya, I, Akushevich, I, and Ukraintseva, SV. "How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data." North American actuarial journal : NAAJ 20, no. 3 (January 2016): 201-232. Full Text Open Access Copy
  - Yashin, AI, Zhbannikov, I, Arbeeva, L, Arbeev, KG, Wu, D, Akushevich, I, Yashkin, A, Kovtun, M, Kulminski, AM, Stallard, E, Kulminskaya, I, and Ukraintseva, S. "Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures." Frontiers in Genetics 7 (January 2016): 188-null. Full Text Open Access Copy
  - Kulminski, AM, Arbeev, KG, Culminskaya, I, Ukraintseva, SV, Stallard, E, Province, MA, and Yashin, AI. "Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study." Rejuvenation Research 18, no. 2 (April 2015): 128-135. Full Text Open Access Copy
  - Kulminski, AM, Culminskaya, I, Arbeev, KG, Arbeeva, L, Ukraintseva, SV, Stallard, E, Wu, D, and Yashin, AI. "Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies." PLoS ONE 10, no. 8 (January 2015): e0136319-. Full Text Open Access Copy
  - Yashin, AI, Wu, D, Arbeeva, LS, Arbeev, KG, Kulminski, AM, Akushevich, I, Kovtun, M, Culminskaya, I, Stallard, E, Li, M, and Ukraintseva, SV. "Genetics of aging, health, and survival: dynamic regulation of human longevity related traits." Frontiers in Genetics 6 (January 2015): 122-null. Full Text Open Access Copy
  - Kulminski, A, Culminskaya, I, and Yashin, AI. "Letter to the editor: Standardization of genetic association studies, pros and cons, reaffirmed." Age 36, no. 2 (January 1, 2014): 945-947. (Letter) Full Text
  - Kulminski, AM, Arbeev, KG, Culminskaya, I, Arbeeva, L, Ukraintseva, SV, Stallard, E, Christensen, K, Schupf, N, Province, MA, and Yashin, AI. "Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan." Plos Genetics 10, no. 1 (January 1, 2014). Full Text
  - Kulminski, AM, Culminskaya, I, Arbeev, KG, Ukraintseva, SV, Stallard, E, Arbeeva, L, and Yashin, AI. "The role of lipid-related genes, aging-related processes, and environment in healthspan." Aging Cell 12, no. 2 (April 2013): 237-246. Full Text Open Access Copy
  - Kulminski, AM, Culminskaya, I, and Yashin, AI. "Inter-chromosomal level of genome organization and longevity-related phenotypes in humans." Age (Dordrecht, Netherlands) 35, no. 2 (April 2013): 501-518. Full Text Open Access Copy
  - Kulminski, AM, and Culminskaya, I. "Genomics of human health and aging." Age (Dordrecht, Netherlands) 35, no. 2 (April 2013): 455-469. Full Text
  - Kulminski, AM, Culminskaya, I, Arbeev, KG, Ukraintseva, SV, Arbeeva, L, and Yashin, AI. "Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations." Rejuvenation research 16, no. 1 (February 2013): 28-34. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Wu, D, Arbeeva, LS, Kulminski, A, Akushevich, I, Culminskaya, I, Stallard, E, and Ukraintseva, SV. "How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data." Frontiers in genetics 4 (January 22, 2013): 3-. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Wu, D, Arbeeva, LS, Kulminski, AM, Akushevich, I, Culminskaya, I, Stallard, E, and Ukraintseva, SV. "How the quality of GWAS of human lifespan and health span can be improved." Frontiers in genetics 4 (January 2013): 125-. Full Text Open Access Copy
  - Kulminski, AM, Culminskaya, I, Ukraintseva, SV, Arbeev, KG, Arbeeva, L, Wu, D, Akushevich, I, Land, KC, and Yashin, AI. "Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan." Aging cell 10, no. 3 (June 2011): 533-541. Full Text Open Access Copy
  - Arbeev, KG, Ukraintseva, SV, Akushevich, I, Kulminski, AM, Arbeeva, LS, Akushevich, L, Culminskaya, IV, and Yashin, AI. "Age trajectories of physiological indices in relation to healthy life course." Mechanisms of Ageing and Development 132, no. 3 (March 2011): 93-102. Full Text Open Access Copy
  - Ukraintseva, SV, Arbeev, KG, Akushevich, I, Kulminski, A, Arbeeva, L, Culminskaya, I, Akushevich, L, and Yashin, AI. "Trade-offs between cancer and other diseases: do they exist and influence longevity?." Rejuvenation research 13, no. 4 (August 2010): 387-396. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Akushevich, I, Ukraintseva, SV, Kulminski, A, Arbeeva, LS, and Culminskaya, I. "Exceptional survivors have lower age trajectories of blood glucose: lessons from longitudinal data." Biogerontology 11, no. 3 (June 2010): 257-265. Full Text
  - Kulminski, AM, Culminskaya, I, Ukraintseva, SV, Arbeev, KG, Land, KC, and Yashin, AI. "Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context." Mechanisms of ageing and development 131, no. 5 (May 2010): 338-345. Full Text Open Access Copy
  - Kulminski, AM, Culminskaya, IV, Ukraintseva, SV, Arbeev, KG, Akushevich, I, Land, KC, and Yashin, AI. "Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction." Rejuvenation research 13, no. 1 (February 2010): 13-21. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Akushevich, I, Arbeeva, L, Kravchenko, J, Il'yasova, D, Kulminski, A, Akushevich, L, Culminskaya, I, Wu, D, and Ukraintseva, SV. "Dynamic determinants of longevity and exceptional health." Current gerontology and geriatrics research (January 2010). Full Text
  - Kulminski, AM, Molleman, F, Culminskaya, IV, Arbeev, KG, Ukraintseva, SV, Carey, JR, and Yashin, AI. "Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens." Experimental gerontology 44, no. 11 (November 2009): 718-726. Full Text
  - Arbeev, KG, Akushevich, I, Kulminski, AM, Arbeeva, LS, Akushevich, L, Ukraintseva, SV, Culminskaya, IV, and Yashin, AI. "Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete data." Journal of theoretical biology 258, no. 1 (May 2009): 103-111. Full Text
  - Kulminski, AM, Arbeev, KG, Culminskaya, IV, Ukraintseva, SV, Christensen, K, and Yashin, AI. "Health-related phenotypes and longevity in danish twins." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 64, no. 1 (January 2009): 1-8. Full Text
  - Shimko, VE, Kulminskaya, IV, Kalitukho, LN, and Gordei, IA. "Comparative analysis of photosynthetic characteristics and productivity in F2 hybrids of winter rye." Russian Journal of Plant Physiology 56, no. 1 (January 2009): 126-132. Full Text
  - Kulminski, AM, Culminskaya, IV, Ukraintseva, SV, Arbeev, KG, Land, KC, and Yashin, AI. "Sex-specific health deterioration and mortality: the morbidity-mortality paradox over age and time." Experimental Gerontology 43, no. 12 (December 2008): 1052-1057. Full Text
  - Kulminski, AM, Ukraintseva, SV, Culminskaya, IV, Arbeev, KG, Land, KC, Akushevich, L, and Yashin, AI. "Cumulative deficits and physiological indices as predictors of mortality and long life." The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 63, no. 10 (October 2008): 1053-1059. Full Text
  - Kulminski, AM, Arbeev, KG, Ukraintseva, SV, Culminskaya, IV, Land, K, and Yashin, AI. "Changes in health status among participants of the Framingham Heart Study from the 1960s to the 1990s: application of an index of cumulative deficits." Annals of epidemiology 18, no. 9 (September 2008): 696-701. Full Text
  - Kulminski, AM, Ukraintseva, SV, Kulminskaya, IV, Arbeev, KG, Land, K, and Yashin, AI. "Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study." Journal of the American Geriatrics Society 56, no. 5 (May 2008): 898-903. Full Text
  - Kulminski, AM, Kulminskaya, IV, Ukraintseva, SV, Land, K, and Yashin, AI. "An inverse association between self-reported arthritis and mortality in the elderly: findings from the national long-term care survey." Rejuvenation Research 11, no. 1 (February 2008): 251-257. Full Text
  - Kulminski, AM, Arbeev, KG, Kulminskaya, IV, Ukraintseva, SV, Land, K, Akushevich, I, and Yashin, AI. "Body mass index and nine-year mortality in disabled and nondisabled older U.S. individuals." Journal of the American Geriatrics Society 56, no. 1 (January 2008): 105-110. Full Text

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Selected Grants

Selected Publications

Journal Articles