Irina Kulminskaya | Scholars@Duke

Irina Kulminskaya
Research Scientist, Senior

Current Appointments & Affiliations

Research Scientist, Senior, Center for Population Health & Aging, Duke Population Research Institute

Contact Information

2024 W Main Street, Erwin Mill Building, Durham, NC 27708
irina.kulminskaya@duke.edu +1 919 681 8232

Research
Selected Grants
- Life Course and Genetic and Non-genetic Factors in Health and Survival awarded by National Institutes of Health 2015 - 2020
- Evaluating New Genetic Effects on Health and Aging from Longitudinal Data awarded by National Institutes of Health 2007 - 2013
Publications & Artistic Works
Selected Publications
- Journal Articles
  - Kulminski, AM, Huang, J, Wang, J, He, L, Loika, Y, and Culminskaya, I. "Apolipoprotein E region molecular signatures of Alzheimer's disease." Aging Cell (May 23, 2018): e12779-null. Full Text
  - Kulminski, AM, Huang, J, Loika, Y, Arbeev, KG, Bagley, O, Yashkin, A, Duan, M, and Culminskaya, I. "Strong impact of natural-selection-free heterogeneity in genetics of age-related phenotypes." Aging 10, no. 3 (March 2018): 492-514. Full Text
  - Yashin, AI, Fang, F, Kovtun, M, Wu, D, Duan, M, Arbeev, K, Akushevich, I, Kulminski, A, Culminskaya, I, Zhbannikov, I, Yashkin, A, Stallard, E, and Ukraintseva, S. "Hidden heterogeneity in Alzheimer's disease: Insights from genetic association studies and other analyses." Experimental gerontology (October 26, 2017). Full Text
  - He, L, Culminskaya, I, Loika, Y, Arbeev, KG, Bagley, O, Duan, M, Yashin, AI, and Kulminski, AM. "Causal effects of cardiovascular risk factors on onset of major age-related diseases: A time-to-event Mendelian randomization study." Experimental gerontology (September 27, 2017). Full Text
  - Kulminski, AM, Kernogitski, Y, Culminskaya, I, Loika, Y, Arbeev, KG, Bagley, O, Duan, M, Arbeeva, L, Ukraintseva, SV, Wu, D, Stallard, E, and Yashin, AI. "Uncoupling associations of risk alleles with endophenotypes and phenotypes: insights from the ApoB locus and heart-related traits." Aging cell 16, no. 1 (February 2017): 61-72. Full Text Open Access Copy
  - He, L, Kernogitski, Y, Kulminskaya, I, Loika, Y, Arbeev, KG, Loiko, E, Bagley, O, Duan, M, Yashkin, A, Ukraintseva, SV, Kovtun, M, Yashin, AI, and Kulminski, AM. "Corrigendum: Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases." Frontiers in Genetics 8 (January 2017): 226-null. Full Text
  - Kulminski, AM, He, L, Culminskaya, I, Loika, Y, Kernogitski, Y, Arbeev, KG, Loiko, E, Arbeeva, L, Bagley, O, Duan, M, Yashkin, A, Fang, F, Kovtun, M, Ukraintseva, SV, Wu, D, and Yashin, AI. "Pleiotropic Associations of Allelic Variants in a 2q22 Region with Risks of Major Human Diseases and Mortality." PLoS genetics 12, no. 11 (November 10, 2016): e1006314-. Full Text
  - Kulminski, AM, Raghavachari, N, Arbeev, KG, Culminskaya, I, Arbeeva, L, Wu, D, Ukraintseva, SV, Christensen, K, and Yashin, AI. "Protective role of the apolipoprotein E2 allele in age-related disease traits and survival: evidence from the Long Life Family Study." Biogerontology 17, no. 5-6 (November 2016): 893-905. Full Text Open Access Copy
  - Kulminski, AM, Loika, Y, Culminskaya, I, Arbeev, KG, Ukraintseva, SV, Stallard, E, and Yashin, AI. "Explicating heterogeneity of complex traits has strong potential for improving GWAS efficiency." Scientific reports 6 (October 14, 2016): 35390-. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Arbeeva, LS, Wu, D, Akushevich, I, Kovtun, M, Yashkin, A, Kulminski, A, Culminskaya, I, Stallard, E, Li, M, and Ukraintseva, SV. "How the effects of aging and stresses of life are integrated in mortality rates: insights for genetic studies of human health and longevity." Biogerontology 17, no. 1 (February 2016): 89-107. (Review) Full Text Open Access Copy
  - He, L, Kernogitski, Y, Kulminskaya, I, Loika, Y, Arbeev, KG, Loiko, E, Bagley, O, Duan, M, Yashkin, A, Ukraintseva, SV, Kovtun, M, Yashin, AI, and Kulminski, AM. "Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases." Frontiers in genetics 7 (January 2016): 179-. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Wu, D, Arbeeva, L, Kulminski, A, Kulminskaya, I, Akushevich, I, and Ukraintseva, SV. "How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data." North American actuarial journal : NAAJ 20, no. 3 (January 2016): 201-232. Full Text Open Access Copy
  - Yashin, AI, Zhbannikov, I, Arbeeva, L, Arbeev, KG, Wu, D, Akushevich, I, Yashkin, A, Kovtun, M, Kulminski, AM, Stallard, E, Kulminskaya, I, and Ukraintseva, S. "Pure and Confounded Effects of Causal SNPs on Longevity: Insights for Proper Interpretation of Research Findings in GWAS of Populations with Different Genetic Structures." Frontiers in Genetics 7 (January 2016): 188-null. Full Text Open Access Copy
  - Kulminski, AM, Arbeev, KG, Culminskaya, I, Ukraintseva, SV, Stallard, E, Province, MA, and Yashin, AI. "Trade-offs in the effects of the apolipoprotein E polymorphism on risks of diseases of the heart, cancer, and neurodegenerative disorders: insights on mechanisms from the Long Life Family Study." Rejuvenation Research 18, no. 2 (April 2015): 128-135. Full Text Open Access Copy
  - Kulminski, AM, Culminskaya, I, Arbeev, KG, Arbeeva, L, Ukraintseva, SV, Stallard, E, Wu, D, and Yashin, AI. "Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies." PLoS ONE 10, no. 8 (January 2015): e0136319-. Full Text Open Access Copy
  - Yashin, AI, Wu, D, Arbeeva, LS, Arbeev, KG, Kulminski, AM, Akushevich, I, Kovtun, M, Culminskaya, I, Stallard, E, Li, M, and Ukraintseva, SV. "Genetics of aging, health, and survival: dynamic regulation of human longevity related traits." Frontiers in genetics 6 (January 2015): 122-. Full Text Open Access Copy
  - Kulminski, A, Culminskaya, I, and Yashin, AI. "Letter to the editor: Standardization of genetic association studies, pros and cons, reaffirmed." Age 36, no. 2 (January 1, 2014): 945-947. (Letter) Full Text
  - Kulminski, AM, Arbeev, KG, Culminskaya, I, Arbeeva, L, Ukraintseva, SV, Stallard, E, Christensen, K, Schupf, N, Province, MA, and Yashin, AI. "Age, Gender, and Cancer but Not Neurodegenerative and Cardiovascular Diseases Strongly Modulate Systemic Effect of the Apolipoprotein E4 Allele on Lifespan." Plos Genetics 10, no. 1 (January 1, 2014). Full Text
  - Kulminski, AM, Culminskaya, I, Arbeev, KG, Ukraintseva, SV, Stallard, E, Arbeeva, L, and Yashin, AI. "The role of lipid-related genes, aging-related processes, and environment in healthspan." Aging cell 12, no. 2 (April 2013): 237-246. Full Text Open Access Copy
  - Kulminski, AM, Culminskaya, I, and Yashin, AI. "Inter-chromosomal level of genome organization and longevity-related phenotypes in humans." Age (Dordrecht, Netherlands) 35, no. 2 (April 2013): 501-518. Full Text Open Access Copy
  - Kulminski, AM, and Culminskaya, I. "Genomics of human health and aging." Age (Dordrecht, Netherlands) 35, no. 2 (April 2013): 455-469. Full Text
  - Kulminski, AM, Culminskaya, I, Arbeev, KG, Ukraintseva, SV, Arbeeva, L, and Yashin, AI. "Trade-off in the effect of the APOE gene on the ages at onset of cardiocascular disease and cancer across ages, gender, and human generations." Rejuvenation research 16, no. 1 (February 2013): 28-34. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Wu, D, Arbeeva, LS, Kulminski, A, Akushevich, I, Culminskaya, I, Stallard, E, and Ukraintseva, SV. "How lifespan associated genes modulate aging changes: lessons from analysis of longitudinal data." Frontiers in genetics 4 (January 22, 2013): 3-. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Wu, D, Arbeeva, LS, Kulminski, AM, Akushevich, I, Culminskaya, I, Stallard, E, and Ukraintseva, SV. "How the quality of GWAS of human lifespan and health span can be improved." Frontiers in genetics 4 (January 2013): 125-. Full Text Open Access Copy
  - Kulminski, AM, Culminskaya, I, Ukraintseva, SV, Arbeev, KG, Arbeeva, L, Wu, D, Akushevich, I, Land, KC, and Yashin, AI. "Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan." Aging cell 10, no. 3 (June 2011): 533-541. Full Text Open Access Copy
  - Arbeev, KG, Ukraintseva, SV, Akushevich, I, Kulminski, AM, Arbeeva, LS, Akushevich, L, Culminskaya, IV, and Yashin, AI. "Age trajectories of physiological indices in relation to healthy life course." Mechanisms of ageing and development 132, no. 3 (March 2011): 93-102. Full Text Open Access Copy
  - Ukraintseva, SV, Arbeev, KG, Akushevich, I, Kulminski, A, Arbeeva, L, Culminskaya, I, Akushevich, L, and Yashin, AI. "Trade-offs between cancer and other diseases: do they exist and influence longevity?." Rejuvenation research 13, no. 4 (August 2010): 387-396. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Akushevich, I, Ukraintseva, SV, Kulminski, A, Arbeeva, LS, and Culminskaya, I. "Exceptional survivors have lower age trajectories of blood glucose: lessons from longitudinal data." Biogerontology 11, no. 3 (June 2010): 257-265. Full Text
  - Kulminski, AM, Culminskaya, I, Ukraintseva, SV, Arbeev, KG, Land, KC, and Yashin, AI. "Beta2-adrenergic receptor gene polymorphisms as systemic determinants of healthy aging in an evolutionary context." Mechanisms of ageing and development 131, no. 5 (May 2010): 338-345. Full Text Open Access Copy
  - Kulminski, AM, Culminskaya, IV, Ukraintseva, SV, Arbeev, KG, Akushevich, I, Land, KC, and Yashin, AI. "Polymorphisms in the ACE and ADRB2 genes and risks of aging-associated phenotypes: the case of myocardial infarction." Rejuvenation research 13, no. 1 (February 2010): 13-21. Full Text Open Access Copy
  - Yashin, AI, Arbeev, KG, Akushevich, I, Arbeeva, L, Kravchenko, J, Il'yasova, D, Kulminski, A, Akushevich, L, Culminskaya, I, Wu, D, and Ukraintseva, SV. "Dynamic determinants of longevity and exceptional health." Current gerontology and geriatrics research (January 2010). Full Text
  - Kulminski, AM, Molleman, F, Culminskaya, IV, Arbeev, KG, Ukraintseva, SV, Carey, JR, and Yashin, AI. "Date of eclosion modulates longevity: insights across dietary-restriction gradients and female reproduction in the mexfly Anastrepha ludens." Experimental gerontology 44, no. 11 (November 2009): 718-726. Full Text
  - Arbeev, KG, Akushevich, I, Kulminski, AM, Arbeeva, LS, Akushevich, L, Ukraintseva, SV, Culminskaya, IV, and Yashin, AI. "Genetic model for longitudinal studies of aging, health, and longevity and its potential application to incomplete data." Journal of theoretical biology 258, no. 1 (May 2009): 103-111. Full Text
  - Kulminski, AM, Arbeev, KG, Culminskaya, IV, Ukraintseva, SV, Christensen, K, and Yashin, AI. "Health-related phenotypes and longevity in danish twins." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 64, no. 1 (January 2009): 1-8. Full Text
  - Shimko, VE, Kulminskaya, IV, Kalitukho, LN, and Gordei, IA. "Comparative analysis of photosynthetic characteristics and productivity in F2 hybrids of winter rye." Russian Journal of Plant Physiology 56, no. 1 (January 2009): 126-132. Full Text
  - Kulminski, AM, Culminskaya, IV, Ukraintseva, SV, Arbeev, KG, Land, KC, and Yashin, AI. "Sex-specific health deterioration and mortality: the morbidity-mortality paradox over age and time." Experimental gerontology 43, no. 12 (December 2008): 1052-1057. Full Text
  - Kulminski, AM, Ukraintseva, SV, Culminskaya, IV, Arbeev, KG, Land, KC, Akushevich, L, and Yashin, AI. "Cumulative deficits and physiological indices as predictors of mortality and long life." The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 63, no. 10 (October 2008): 1053-1059. Full Text
  - Kulminski, AM, Arbeev, KG, Ukraintseva, SV, Culminskaya, IV, Land, K, and Yashin, AI. "Changes in health status among participants of the Framingham Heart Study from the 1960s to the 1990s: application of an index of cumulative deficits." Annals of epidemiology 18, no. 9 (September 2008): 696-701. Full Text
  - Kulminski, AM, Ukraintseva, SV, Kulminskaya, IV, Arbeev, KG, Land, K, and Yashin, AI. "Cumulative deficits better characterize susceptibility to death in elderly people than phenotypic frailty: lessons from the Cardiovascular Health Study." Journal of the American Geriatrics Society 56, no. 5 (May 2008): 898-903. Full Text
  - Kulminski, AM, Kulminskaya, IV, Ukraintseva, SV, Land, K, and Yashin, AI. "An inverse association between self-reported arthritis and mortality in the elderly: findings from the national long-term care survey." Rejuvenation research 11, no. 1 (February 2008): 251-257. Full Text
  - Kulminski, AM, Arbeev, KG, Kulminskaya, IV, Ukraintseva, SV, Land, K, Akushevich, I, and Yashin, AI. "Body mass index and nine-year mortality in disabled and nondisabled older U.S. individuals." Journal of the American Geriatrics Society 56, no. 1 (January 2008): 105-110. Full Text

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Selected Grants

Selected Publications

Journal Articles