Current Appointments & Affiliations
Research Scientist, Senior
Center for Population Health & Aging,
Duke Population Research Institute
Recent Publications
Basic Science and Pathogenesis
Journal Article Alzheimer's & dementia : the journal of the Alzheimer's Association · December 1, 2024 BACKGROUND: The Alzheimer's Association reports that more than two-thirds of the approximately 5 million Alzheimer's disease (AD) cases in the USA are women. With studies suggesting a high genetic heritability for AD, gaining a better understanding of the ... Full text CitePleiotropic Associations with Alzheimer's Disease and Physical Activity: Sex Differences and the Effects of Environment.
Journal Article International journal of molecular sciences · November 2024 Physical activity (PA) is a modifiable factor in mitigating/preventing Alzheimer's disease (AD). It is crucial to identify the conditions under which PA's effects on AD risk would be beneficial. This study aims to gain insights into pleiotropic predisposit ... Full text Cite<i>TOMM40</i> and <i>APOC1</i> variants differentiate the impacts of the <i>APOE ε</i>4 allele on Alzheimer's disease risk across sexes, ages, and ancestries.
Journal Article Alzheimer's & dementia (Amsterdam, Netherlands) · April 2024 IntroductionThe variability in apolipoprotein E (APOE) ε4-attributed susceptibility to Alzheimer's disease (AD) across ancestries, sexes, and ages may stem from the modulating effects of other genetic variants.MethodsWe exam ... Full text CiteRecent Grants
Dissecting genetic and non-genetic heterogeneity in predisposition to Alzheimer's disease and vascular traits in pleiotropic context
ResearchSenior Investigator · Awarded by National Institutes of Health · 2020 - 2026Personalized genetic profiles of risk and resilience in Alzheimer's and vascular diseases
ResearchSenior Investigator · Awarded by National Institute on Aging · 2020 - 2026ApoE2 and protective molecular signatures in Alzheimer's disease and aging
ResearchSenior Investigator · Awarded by National Institutes of Health · 2018 - 2025View All Grants