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Genetic influences on CHD-death and the impact of known risk factors: comparison of two frailty models.

Publication ,  Journal Article
Zdravkovic, S; Wienke, A; Pedersen, NL; Marenberg, ME; Yashin, AI; de Faire, U
Published in: Behavior genetics
November 2004

The importance of some recognized risk factors on genetic influences for coronary heart disease (CHD) needs further clarification. The aim of the present study was therefore to study the impact of known risk factors on genetic influences for CHD-death. Both twin (correlated gamma-frailty) and non-twin models (univariate gamma-frailty) were utilized and compared regarding their suitability for genetic analyses. The study population consisted of twins born in Sweden between 1886 and 1925. As expected, our findings indicate that genetic influences are important for CHD-death. Inclusion of risk factors in the twin-model increased heritability estimates, primarily due to a substantial reduction in non-shared environmental variances. The genetic influences for CHD-death are only marginally mediated through the risk factors among males, but more so among females. Although the outcome phenotype used in the present study is not behavioral, the analyses demonstrate the potential of frailty models for quantitative genetic analyses of categorical phenotypes.

Duke Scholars

Published In

Behavior genetics

DOI

EISSN

1573-3297

ISSN

0001-8244

Publication Date

November 2004

Volume

34

Issue

6

Start / End Page

585 / 592

Related Subject Headings

  • Twin Studies as Topic
  • Smoking
  • Sex Characteristics
  • Risk Factors
  • Proportional Hazards Models
  • Models, Biological
  • Marital Status
  • Male
  • Humans
  • Genetics & Heredity
 

Citation

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Zdravkovic, S., Wienke, A., Pedersen, N. L., Marenberg, M. E., Yashin, A. I., & de Faire, U. (2004). Genetic influences on CHD-death and the impact of known risk factors: comparison of two frailty models. Behavior Genetics, 34(6), 585–592. https://doi.org/10.1007/s10519-004-5586-1
Zdravkovic, Slobodan, Andreas Wienke, Nancy L. Pedersen, Marjorie E. Marenberg, Anatoli I. Yashin, and Ulf de Faire. “Genetic influences on CHD-death and the impact of known risk factors: comparison of two frailty models.Behavior Genetics 34, no. 6 (November 2004): 585–92. https://doi.org/10.1007/s10519-004-5586-1.
Zdravkovic S, Wienke A, Pedersen NL, Marenberg ME, Yashin AI, de Faire U. Genetic influences on CHD-death and the impact of known risk factors: comparison of two frailty models. Behavior genetics. 2004 Nov;34(6):585–92.
Zdravkovic, Slobodan, et al. “Genetic influences on CHD-death and the impact of known risk factors: comparison of two frailty models.Behavior Genetics, vol. 34, no. 6, Nov. 2004, pp. 585–92. Epmc, doi:10.1007/s10519-004-5586-1.
Zdravkovic S, Wienke A, Pedersen NL, Marenberg ME, Yashin AI, de Faire U. Genetic influences on CHD-death and the impact of known risk factors: comparison of two frailty models. Behavior genetics. 2004 Nov;34(6):585–592.
Journal cover image

Published In

Behavior genetics

DOI

EISSN

1573-3297

ISSN

0001-8244

Publication Date

November 2004

Volume

34

Issue

6

Start / End Page

585 / 592

Related Subject Headings

  • Twin Studies as Topic
  • Smoking
  • Sex Characteristics
  • Risk Factors
  • Proportional Hazards Models
  • Models, Biological
  • Marital Status
  • Male
  • Humans
  • Genetics & Heredity