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Cumulative deficits and physiological indices as predictors of mortality and long life.

Publication ,  Journal Article
Kulminski, AM; Ukraintseva, SV; Culminskaya, IV; Arbeev, KG; Land, KC; Akushevich, L; Yashin, AI
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences
October 2008

We evaluated the predictive potential for long-term (24-year) survival and longevity (85+ years) of an index of cumulative deficits (DI) and six physiological indices (pulse pressure, diastolic blood pressure, pulse rate, serum cholesterol, blood glucose, and hematocrit) measured in mid- to late life (44-88 years) for participants of the 9th and 14th Framingham Heart Study examinations. For all ages combined, the DI, pulse pressure, and blood glucose are the strongest determinants of both long-term survival and longevity, contributing cumulatively to their explanation. Diastolic blood pressure and hematocrit are less significant determinants of both of these outcomes. The pulse rate is more relevant to survival, whereas serum cholesterol is more relevant to longevity. Only the DI is a significant predictor of longevity and mortality for each 5-year age group ranging from 45 to 85 years. The DI appears to be a more important determinant of long-term risks of death and longevity than are the physiological indices.

Duke Scholars

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

October 2008

Volume

63

Issue

10

Start / End Page

1053 / 1059

Related Subject Headings

  • Risk Factors
  • Regression Analysis
  • Pulse
  • Predictive Value of Tests
  • Mortality
  • Middle Aged
  • Male
  • Longevity
  • Humans
  • Hematocrit
 

Citation

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Kulminski, A. M., Ukraintseva, S. V., Culminskaya, I. V., Arbeev, K. G., Land, K. C., Akushevich, L., & Yashin, A. I. (2008). Cumulative deficits and physiological indices as predictors of mortality and long life. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 63(10), 1053–1059. https://doi.org/10.1093/gerona/63.10.1053
Kulminski, Alexander M., Svetlana V. Ukraintseva, Irina V. Culminskaya, Konstantin G. Arbeev, Kenneth C. Land, Lucy Akushevich, and Anatoli I. Yashin. “Cumulative deficits and physiological indices as predictors of mortality and long life.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 63, no. 10 (October 2008): 1053–59. https://doi.org/10.1093/gerona/63.10.1053.
Kulminski AM, Ukraintseva SV, Culminskaya IV, Arbeev KG, Land KC, Akushevich L, et al. Cumulative deficits and physiological indices as predictors of mortality and long life. The journals of gerontology Series A, Biological sciences and medical sciences. 2008 Oct;63(10):1053–9.
Kulminski, Alexander M., et al. “Cumulative deficits and physiological indices as predictors of mortality and long life.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 63, no. 10, Oct. 2008, pp. 1053–59. Epmc, doi:10.1093/gerona/63.10.1053.
Kulminski AM, Ukraintseva SV, Culminskaya IV, Arbeev KG, Land KC, Akushevich L, Yashin AI. Cumulative deficits and physiological indices as predictors of mortality and long life. The journals of gerontology Series A, Biological sciences and medical sciences. 2008 Oct;63(10):1053–1059.
Journal cover image

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

October 2008

Volume

63

Issue

10

Start / End Page

1053 / 1059

Related Subject Headings

  • Risk Factors
  • Regression Analysis
  • Pulse
  • Predictive Value of Tests
  • Mortality
  • Middle Aged
  • Male
  • Longevity
  • Humans
  • Hematocrit