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Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies.

Publication ,  Journal Article
Yashin, AI; Ukraintseva, SV; Akushevich, IV; Arbeev, KG; Kulminski, A; Akushevich, L
Published in: Mechanisms of Ageing and Development
January 2009

The potential gain in life expectancy which could result from the complete elimination of mortality from cancer in the U.S. would not exceed 3 years if one were to consider cancer independently of other causes of death. In this paper, we review evidence of trade-offs between cancer and aging as well as between cancer and other diseases, which, if taken into account, may substantially increase estimates of gain in life expectancy resulting from cancer eradication. We also used the Multiple Causes of Death (MCD) data to evaluate correlations among mortalities from cancer and other major disorders including heart disease, stroke, diabetes, Alzheimer's, Parkinson's diseases, and asthma. Our analyses revealed significant negative correlations between cancer and other diseases suggesting stronger population effects of cancer eradication. Possible mechanisms of the observed dependencies and emerging perspectives of using dependent competing risks models for evaluating the effects of reduction of mortality from cancer on life expectancy are discussed.

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Published In

Mechanisms of Ageing and Development

DOI

EISSN

1872-6216

ISSN

0047-6374

Publication Date

January 2009

Volume

130

Issue

1-2

Start / End Page

98 / 104

Related Subject Headings

  • Risk Factors
  • Neoplasms
  • Models, Statistical
  • Life Expectancy
  • Humans
  • Gerontology
  • Chronic Disease
  • Cause of Death
  • Animals
  • Aging
 

Citation

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ICMJE
MLA
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Yashin, A. I., Ukraintseva, S. V., Akushevich, I. V., Arbeev, K. G., Kulminski, A., & Akushevich, L. (2009). Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies. Mechanisms of Ageing and Development, 130(1–2), 98–104. https://doi.org/10.1016/j.mad.2008.03.006
Yashin, Anatoli I., Svetlana V. Ukraintseva, Igor V. Akushevich, Konstantin G. Arbeev, Alexander Kulminski, and Lucy Akushevich. “Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies.Mechanisms of Ageing and Development 130, no. 1–2 (January 2009): 98–104. https://doi.org/10.1016/j.mad.2008.03.006.
Yashin AI, Ukraintseva SV, Akushevich IV, Arbeev KG, Kulminski A, Akushevich L. Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies. Mechanisms of Ageing and Development. 2009 Jan;130(1–2):98–104.
Yashin, Anatoli I., et al. “Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies.Mechanisms of Ageing and Development, vol. 130, no. 1–2, Jan. 2009, pp. 98–104. Epmc, doi:10.1016/j.mad.2008.03.006.
Yashin AI, Ukraintseva SV, Akushevich IV, Arbeev KG, Kulminski A, Akushevich L. Trade-off between cancer and aging: what role do other diseases play? Evidence from experimental and human population studies. Mechanisms of Ageing and Development. 2009 Jan;130(1–2):98–104.
Journal cover image

Published In

Mechanisms of Ageing and Development

DOI

EISSN

1872-6216

ISSN

0047-6374

Publication Date

January 2009

Volume

130

Issue

1-2

Start / End Page

98 / 104

Related Subject Headings

  • Risk Factors
  • Neoplasms
  • Models, Statistical
  • Life Expectancy
  • Humans
  • Gerontology
  • Chronic Disease
  • Cause of Death
  • Animals
  • Aging