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Handbook on Immunosenescence: Basic Understanding and Clinical Applications

Mathematical modeling of immunosenescence: Scenarios, processes and limitations

Publication ,  Chapter
Romanyukha, AA; Rudnev, SG; Sannikova, TA; Yashin, AI
January 1, 2009

Mathematical modeling of immunosenescence is the new area of research emerging at the interface of the immunology, gerontology, and mathematics. In this paper we outline basic variables important for modeling aging immunity. We discuss the role of evolution in shaping pattern of aging in the immune system of modern humans. We investigate mathematical models of postnatal changes in the population of peripheral T-cells, effects of the antigenic load during development on the body growth, and contribution of immunosenescence to the old age increase in the risk of death from respiratory infections.

Duke Scholars

DOI

Publication Date

January 1, 2009

Volume

9781402090639

Start / End Page

145 / 163
 

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Romanyukha, A. A., Rudnev, S. G., Sannikova, T. A., & Yashin, A. I. (2009). Mathematical modeling of immunosenescence: Scenarios, processes and limitations. In Handbook on Immunosenescence: Basic Understanding and Clinical Applications (Vol. 9781402090639, pp. 145–163). https://doi.org/10.1007/978-1-4020-9063-9_8
Romanyukha, A. A., S. G. Rudnev, T. A. Sannikova, and A. I. Yashin. “Mathematical modeling of immunosenescence: Scenarios, processes and limitations.” In Handbook on Immunosenescence: Basic Understanding and Clinical Applications, 9781402090639:145–63, 2009. https://doi.org/10.1007/978-1-4020-9063-9_8.
Romanyukha AA, Rudnev SG, Sannikova TA, Yashin AI. Mathematical modeling of immunosenescence: Scenarios, processes and limitations. In: Handbook on Immunosenescence: Basic Understanding and Clinical Applications. 2009. p. 145–63.
Romanyukha, A. A., et al. “Mathematical modeling of immunosenescence: Scenarios, processes and limitations.” Handbook on Immunosenescence: Basic Understanding and Clinical Applications, vol. 9781402090639, 2009, pp. 145–63. Scopus, doi:10.1007/978-1-4020-9063-9_8.
Romanyukha AA, Rudnev SG, Sannikova TA, Yashin AI. Mathematical modeling of immunosenescence: Scenarios, processes and limitations. Handbook on Immunosenescence: Basic Understanding and Clinical Applications. 2009. p. 145–163.

DOI

Publication Date

January 1, 2009

Volume

9781402090639

Start / End Page

145 / 163