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Health and function of participants in the Long Life Family Study: A comparison with other cohorts.

Publication ,  Journal Article
Newman, AB; Glynn, NW; Taylor, CA; Sebastiani, P; Perls, TT; Mayeux, R; Christensen, K; Zmuda, JM; Barral, S; Lee, JH; Simonsick, EM ...
Published in: Aging
January 2011

Individuals from families recruited for the Long Life Family Study (LLFS) (n= 4559) were examined and compared to individuals from other cohorts to determine whether the recruitment targeting longevity resulted in a cohort of individuals with better health and function. Other cohorts with similar data included the Cardiovascular Health Study, the Framingham Heart Study, and the New England Centenarian Study. Diabetes, chronic pulmonary disease and peripheral artery disease tended to be less common in LLFS probands and offspring compared to similar aged persons in the other cohorts. Pulse pressure and triglycerides were lower, high density lipids were higher, and a perceptual speed task and gait speed were better in LLFS. Age-specific comparisons showed differences that would be consistent with a higher peak, later onset of decline or slower rate of change across age in LLFS participants. These findings suggest several priority phenotypes for inclusion in future genetic analysis to identify loci contributing to exceptional survival.

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Published In

Aging

DOI

EISSN

1945-4589

ISSN

1945-4589

Publication Date

January 2011

Volume

3

Issue

1

Start / End Page

63 / 76

Related Subject Headings

  • Research Design
  • Psychomotor Performance
  • Middle Aged
  • Male
  • Longevity
  • Humans
  • Gait
  • Female
  • Developmental Biology
  • Cohort Studies
 

Citation

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ICMJE
MLA
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Newman, A. B., Glynn, N. W., Taylor, C. A., Sebastiani, P., Perls, T. T., Mayeux, R., … Hadley, E. (2011). Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging, 3(1), 63–76. https://doi.org/10.18632/aging.100242
Newman, Anne B., Nancy W. Glynn, Christopher A. Taylor, Paola Sebastiani, Thomas T. Perls, Richard Mayeux, Kaare Christensen, et al. “Health and function of participants in the Long Life Family Study: A comparison with other cohorts.Aging 3, no. 1 (January 2011): 63–76. https://doi.org/10.18632/aging.100242.
Newman AB, Glynn NW, Taylor CA, Sebastiani P, Perls TT, Mayeux R, et al. Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging. 2011 Jan;3(1):63–76.
Newman, Anne B., et al. “Health and function of participants in the Long Life Family Study: A comparison with other cohorts.Aging, vol. 3, no. 1, Jan. 2011, pp. 63–76. Epmc, doi:10.18632/aging.100242.
Newman AB, Glynn NW, Taylor CA, Sebastiani P, Perls TT, Mayeux R, Christensen K, Zmuda JM, Barral S, Lee JH, Simonsick EM, Walston JD, Yashin AI, Hadley E. Health and function of participants in the Long Life Family Study: A comparison with other cohorts. Aging. 2011 Jan;3(1):63–76.

Published In

Aging

DOI

EISSN

1945-4589

ISSN

1945-4589

Publication Date

January 2011

Volume

3

Issue

1

Start / End Page

63 / 76

Related Subject Headings

  • Research Design
  • Psychomotor Performance
  • Middle Aged
  • Male
  • Longevity
  • Humans
  • Gait
  • Female
  • Developmental Biology
  • Cohort Studies