Telomeres and the natural lifespan limit in humans.
Publication
, Journal Article
Steenstrup, T; Kark, JD; Verhulst, S; Thinggaard, M; Hjelmborg, JVB; Dalgård, C; Kyvik, KO; Christiansen, L; Mangino, M; Spector, TD; Kimura, M ...
Published in: Aging
April 2017
An ongoing debate in demography has focused on whether the human lifespan has a maximal natural limit. Taking a mechanistic perspective, and knowing that short telomeres are associated with diminished longevity, we examined whether telomere length dynamics during adult life could set a maximal natural lifespan limit. We define leukocyte telomere length of 5 kb as the 'telomeric brink', which denotes a high risk of imminent death. We show that a subset of adults may reach the telomeric brink within the current life expectancy and more so for a 100-year life expectancy. Thus, secular trends in life expectancy should confront a biological limit due to crossing the telomeric brink.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Aging
DOI
EISSN
1945-4589
ISSN
1945-4589
Publication Date
April 2017
Volume
9
Issue
4
Start / End Page
1130 / 1142
Related Subject Headings
- Telomere Shortening
- Telomere
- Sex Characteristics
- Models, Biological
- Middle Aged
- Male
- Longevity
- Life Expectancy
- Leukocytes
- Humans
Citation
APA
Chicago
ICMJE
MLA
NLM
Steenstrup, T., Kark, J. D., Verhulst, S., Thinggaard, M., Hjelmborg, J. V. B., Dalgård, C., … Aviv, A. (2017). Telomeres and the natural lifespan limit in humans. Aging, 9(4), 1130–1142. https://doi.org/10.18632/aging.101216
Steenstrup, Troels, Jeremy D. Kark, Simon Verhulst, Mikael Thinggaard, Jacob V. B. Hjelmborg, Christine Dalgård, Kirsten Ohm Kyvik, et al. “Telomeres and the natural lifespan limit in humans.” Aging 9, no. 4 (April 2017): 1130–42. https://doi.org/10.18632/aging.101216.
Steenstrup T, Kark JD, Verhulst S, Thinggaard M, Hjelmborg JVB, Dalgård C, et al. Telomeres and the natural lifespan limit in humans. Aging. 2017 Apr;9(4):1130–42.
Steenstrup, Troels, et al. “Telomeres and the natural lifespan limit in humans.” Aging, vol. 9, no. 4, Apr. 2017, pp. 1130–42. Epmc, doi:10.18632/aging.101216.
Steenstrup T, Kark JD, Verhulst S, Thinggaard M, Hjelmborg JVB, Dalgård C, Kyvik KO, Christiansen L, Mangino M, Spector TD, Petersen I, Kimura M, Benetos A, Labat C, Sinnreich R, Hwang S-J, Levy D, Hunt SC, Fitzpatrick AL, Chen W, Berenson GS, Barbieri M, Paolisso G, Gadalla SM, Savage SA, Christensen K, Yashin AI, Arbeev KG, Aviv A. Telomeres and the natural lifespan limit in humans. Aging. 2017 Apr;9(4):1130–1142.
Published In
Aging
DOI
EISSN
1945-4589
ISSN
1945-4589
Publication Date
April 2017
Volume
9
Issue
4
Start / End Page
1130 / 1142
Related Subject Headings
- Telomere Shortening
- Telomere
- Sex Characteristics
- Models, Biological
- Middle Aged
- Male
- Longevity
- Life Expectancy
- Leukocytes
- Humans