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GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.

Publication ,  Journal Article
Zeng, Y; Chen, H; Ni, T; Ruan, R; Feng, L; Nie, C; Cheng, L; Li, Y; Tao, W; Gu, J; Land, KC; Yashin, A; Tan, Q; Yang, Z; Bolund, L ...
Published in: J Gerontol a Biol Sci Med Sci
April 2015

Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+ demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292 and tea drinking at around age 60 or at present time were significantly associated with lower risk of cognitive disability at advanced ages. Associations between tea drinking and reduced cognitive disability were much stronger among carriers of the genotypes of FOXO1A-266 or FOXO3-310 or FOXO3-292 compared with noncarriers, and it was reconfirmed by analysis of three-way interactions across FOXO genotypes, tea drinking at around age 60, and at present time. Based on prior findings from animal and human cell models, we postulate that intake of tea compounds may activate FOXO gene expression, which in turn may positively affect cognitive function in the oldest old population. Our empirical findings imply that the health benefits of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles.

Duke Scholars

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Published In

J Gerontol a Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

April 2015

Volume

70

Issue

4

Start / End Page

426 / 433

Location

United States

Related Subject Headings

  • Tea
  • Surveys and Questionnaires
  • Risk Factors
  • Phenotype
  • Male
  • Longitudinal Studies
  • Humans
  • Gerontology
  • Genotype
  • Gene Expression
 

Citation

APA
Chicago
ICMJE
MLA
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Zeng, Y., Chen, H., Ni, T., Ruan, R., Feng, L., Nie, C., … Vaupel, J. W. (2015). GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China. J Gerontol a Biol Sci Med Sci, 70(4), 426–433. https://doi.org/10.1093/gerona/glu060
Zeng, Yi, Huashuai Chen, Ting Ni, Rongping Ruan, Lei Feng, Chao Nie, Lingguo Cheng, et al. “GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.J Gerontol a Biol Sci Med Sci 70, no. 4 (April 2015): 426–33. https://doi.org/10.1093/gerona/glu060.
Zeng Y, Chen H, Ni T, Ruan R, Feng L, Nie C, et al. GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China. J Gerontol a Biol Sci Med Sci. 2015 Apr;70(4):426–33.
Zeng, Yi, et al. “GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.J Gerontol a Biol Sci Med Sci, vol. 70, no. 4, Apr. 2015, pp. 426–33. Pubmed, doi:10.1093/gerona/glu060.
Zeng Y, Chen H, Ni T, Ruan R, Feng L, Nie C, Cheng L, Li Y, Tao W, Gu J, Land KC, Yashin A, Tan Q, Yang Z, Bolund L, Yang H, Hauser E, Willcox DC, Willcox BJ, Tian X-L, Vaupel JW. GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China. J Gerontol a Biol Sci Med Sci. 2015 Apr;70(4):426–433.
Journal cover image

Published In

J Gerontol a Biol Sci Med Sci

DOI

EISSN

1758-535X

Publication Date

April 2015

Volume

70

Issue

4

Start / End Page

426 / 433

Location

United States

Related Subject Headings

  • Tea
  • Surveys and Questionnaires
  • Risk Factors
  • Phenotype
  • Male
  • Longitudinal Studies
  • Humans
  • Gerontology
  • Genotype
  • Gene Expression