Skip to main content
Journal cover image

Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men.

Publication ,  Journal Article
Kulminski, AM; Ukraintseva, SV; Arbeev, KG; Manton, KG; Oshima, J; Martin, GM; Il'yasova, D; Yashin, AI
Published in: J Am Geriatr Soc
March 2008

OBJECTIVES: To reexamine a health-protective role of the common apolipoprotein E (APOE) polymorphism focusing on connections between the APOE epsilon2-containing genotypes and impairments in instrumental activities of daily living (IADLs) in older (> or = 65) men and women and to examine how diagnosed coronary heart disease (CHD), Alzheimer's disease, colorectal cancer, macular degeneration, and atherosclerosis may mediate these connections. DESIGN: Retrospective cross-sectional study. SETTING: The unique disability-focused data from a genetic subsample of the 1999 National Long Term Care Survey linked with Medicare service use files. PARTICIPANTS: One thousand seven hundred thirty-three genotyped individuals interviewed regarding IADL disabilities. MEASUREMENTS: Indicators of IADL impairments, five geriatric disorders, and epsilon2-containing genotypes. RESULTS: The epsilon2/3 genotype is a major contributor to adverse associations between the epsilon2 allele and IADL disability in men (odds ratio (OR)=3.09, 95% confidence interval (CI)=1.53-6.26), although it provides significant protective effects for CHD (OR=0.55, 95% CI=0.33-0.92), whereas CHD is adversely associated with IADL disability (OR=2.18, 95% CI=1.28-3.72). Adjustment for five diseases does not significantly alter the adverse association between epsilon2-containing genotypes and disability. Protective effects of the epsilon2/3 genotype for CHD (OR=0.52, 95% CI=0.27-0.99) and deleterious effects for IADLs (OR=3.50, 95% CI=1.71-7.14) for men hold in multivariate models with both these factors included. No significant associations between the epsilon2-containing genotypes and IADL are found in women. CONCLUSION: The epsilon2 allele can play a dual role in men, protecting them against some health disorders, while promoting others. Strong adverse relationships with disability suggest that epsilon2-containing genotypes can be unfavorable factors for the health and well-being of aging men.

Duke Scholars

Published In

J Am Geriatr Soc

DOI

EISSN

1532-5415

Publication Date

March 2008

Volume

56

Issue

3

Start / End Page

478 / 483

Location

United States

Related Subject Headings

  • Sex Factors
  • Retrospective Studies
  • Polymorphism, Genetic
  • Male
  • Macular Degeneration
  • Humans
  • Geriatrics
  • Genotype
  • Female
  • Cross-Sectional Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kulminski, A. M., Ukraintseva, S. V., Arbeev, K. G., Manton, K. G., Oshima, J., Martin, G. M., … Yashin, A. I. (2008). Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men. J Am Geriatr Soc, 56(3), 478–483. https://doi.org/10.1111/j.1532-5415.2007.01574.x
Kulminski, Alexander M., Svetlana V. Ukraintseva, Konstantin G. Arbeev, Kenneth G. Manton, Junko Oshima, George M. Martin, Dora Il’yasova, and Anatoli I. Yashin. “Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men.J Am Geriatr Soc 56, no. 3 (March 2008): 478–83. https://doi.org/10.1111/j.1532-5415.2007.01574.x.
Kulminski AM, Ukraintseva SV, Arbeev KG, Manton KG, Oshima J, Martin GM, et al. Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men. J Am Geriatr Soc. 2008 Mar;56(3):478–83.
Kulminski, Alexander M., et al. “Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men.J Am Geriatr Soc, vol. 56, no. 3, Mar. 2008, pp. 478–83. Pubmed, doi:10.1111/j.1532-5415.2007.01574.x.
Kulminski AM, Ukraintseva SV, Arbeev KG, Manton KG, Oshima J, Martin GM, Il’yasova D, Yashin AI. Health-protective and adverse effects of the apolipoprotein E epsilon2 allele in older men. J Am Geriatr Soc. 2008 Mar;56(3):478–483.
Journal cover image

Published In

J Am Geriatr Soc

DOI

EISSN

1532-5415

Publication Date

March 2008

Volume

56

Issue

3

Start / End Page

478 / 483

Location

United States

Related Subject Headings

  • Sex Factors
  • Retrospective Studies
  • Polymorphism, Genetic
  • Male
  • Macular Degeneration
  • Humans
  • Geriatrics
  • Genotype
  • Female
  • Cross-Sectional Studies