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Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.

Publication ,  Journal Article
Anisimov, VN; Khavinson, VK; Popovich, IG; Zabezhinski, MA; Alimova, IN; Rosenfeld, SV; Zavarzina, NY; Semenchenko, AV; Yashin, AI
Published in: Biogerontology
January 2003

From the age of 3 months until their natural deaths, female outbred Swiss-derived SHR mice were subcutaneously injected on 5 consecutive days every month with 0.1 ml of normal saline (control) or with 1.0 microg/mouse (approximately 30-40 microg/kg) of tetrapeptide Epitalon (Ala-Glu-Asp-Gly) dissolved in 0.1 ml saline. There were 54 mice in each group. The results of this study show that treatment with Epitalon did not influence food consumption, body weight or mean life span of mice. However, it slowed down the age-related switching-off of estrous function and decreased the frequency of chromosome aberrations in bone marrow cells (by 17.1%, P<0.05). It also increased by 13.3% the life span of the last 10% of the survivors (P<0.01) and by 12.3% the maximum life span in comparison with the control group. We also found that treatment with Epitalon did not influence total spontaneous tumor incidence, but inhibited the development of leukemia (6.0-fold), as compared with the control group. The data obtained suggest a geroprotector activity of Epitalon and the safety of its long-term administration in mice.

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Published In

Biogerontology

DOI

EISSN

1573-6768

ISSN

1389-5729

Publication Date

January 2003

Volume

4

Issue

4

Start / End Page

193 / 202

Related Subject Headings

  • Oligopeptides
  • Neoplasms, Experimental
  • Mice
  • Life Expectancy
  • Gerontology
  • Female
  • Feeding Behavior
  • Estrus
  • Chromosome Aberrations
  • Bone Marrow Cells
 

Citation

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Anisimov, V. N., Khavinson, V. K., Popovich, I. G., Zabezhinski, M. A., Alimova, I. N., Rosenfeld, S. V., … Yashin, A. I. (2003). Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology, 4(4), 193–202. https://doi.org/10.1023/a:1025114230714
Anisimov, Vladimir N., Vladimir Kh Khavinson, Irina G. Popovich, Mark A. Zabezhinski, Irina N. Alimova, Svetlana V. Rosenfeld, Natalia Yu Zavarzina, Anna V. Semenchenko, and Anatoli I. Yashin. “Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.Biogerontology 4, no. 4 (January 2003): 193–202. https://doi.org/10.1023/a:1025114230714.
Anisimov VN, Khavinson VK, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003 Jan;4(4):193–202.
Anisimov, Vladimir N., et al. “Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.Biogerontology, vol. 4, no. 4, Jan. 2003, pp. 193–202. Epmc, doi:10.1023/a:1025114230714.
Anisimov VN, Khavinson VK, Popovich IG, Zabezhinski MA, Alimova IN, Rosenfeld SV, Zavarzina NY, Semenchenko AV, Yashin AI. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003 Jan;4(4):193–202.
Journal cover image

Published In

Biogerontology

DOI

EISSN

1573-6768

ISSN

1389-5729

Publication Date

January 2003

Volume

4

Issue

4

Start / End Page

193 / 202

Related Subject Headings

  • Oligopeptides
  • Neoplasms, Experimental
  • Mice
  • Life Expectancy
  • Gerontology
  • Female
  • Feeding Behavior
  • Estrus
  • Chromosome Aberrations
  • Bone Marrow Cells