Joint influence of small-effect genetic variants on human longevity.
Publication
, Journal Article
Yashin, AI; Wu, D; Arbeev, KG; Ukraintseva, SV
Published in: Aging
September 2010
The results of genome-wide association studies of complex traits, such as life span or age at onset of chronic disease, suggest that such traits are typically affected by a large number of small-effect alleles. Individually such alleles have little predictive values, therefore they were usually excluded from further analyses. The results of our study strongly suggest that the alleles with small individual effects on longevity may jointly influence life span so that the resulting influence can be both substantial and significant. We show that this joint influence can be described by a relatively simple "genetic dose - phenotypic response" relationship.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Aging
DOI
EISSN
1945-4589
ISSN
1945-4589
Publication Date
September 2010
Volume
2
Issue
9
Start / End Page
612 / 620
Related Subject Headings
- Polymorphism, Single Nucleotide
- Longevity
- Humans
- Genome, Human
- Genetic Variation
- Developmental Biology
- Alleles
- Aging
- 1112 Oncology and Carcinogenesis
- 0606 Physiology
Citation
APA
Chicago
ICMJE
MLA
NLM
Yashin, A. I., Wu, D., Arbeev, K. G., & Ukraintseva, S. V. (2010). Joint influence of small-effect genetic variants on human longevity. Aging, 2(9), 612–620. https://doi.org/10.18632/aging.100191
Yashin, Anatoliy I., Deqing Wu, Konstantin G. Arbeev, and Svetlana V. Ukraintseva. “Joint influence of small-effect genetic variants on human longevity.” Aging 2, no. 9 (September 2010): 612–20. https://doi.org/10.18632/aging.100191.
Yashin AI, Wu D, Arbeev KG, Ukraintseva SV. Joint influence of small-effect genetic variants on human longevity. Aging. 2010 Sep;2(9):612–20.
Yashin, Anatoliy I., et al. “Joint influence of small-effect genetic variants on human longevity.” Aging, vol. 2, no. 9, Sept. 2010, pp. 612–20. Epmc, doi:10.18632/aging.100191.
Yashin AI, Wu D, Arbeev KG, Ukraintseva SV. Joint influence of small-effect genetic variants on human longevity. Aging. 2010 Sep;2(9):612–620.
Published In
Aging
DOI
EISSN
1945-4589
ISSN
1945-4589
Publication Date
September 2010
Volume
2
Issue
9
Start / End Page
612 / 620
Related Subject Headings
- Polymorphism, Single Nucleotide
- Longevity
- Humans
- Genome, Human
- Genetic Variation
- Developmental Biology
- Alleles
- Aging
- 1112 Oncology and Carcinogenesis
- 0606 Physiology