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Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans.

Publication ,  Journal Article
Wu, D; Cypser, JR; Yashin, AI; Johnson, TE
Published in: Experimental gerontology
September 2009

Exposure to mild heat-stress (heat-shock) can significantly increase the life expectancy of the nematode Caenorhabditis elegans. A single heat-shock early in life extends longevity by 20% or more and affects life-long mortality by decreasing initial mortality only; the rate of increase in subsequent mortality (Gompertz component) is unchanged. Repeated mild heat-shocks throughout life have a larger effect on life span than does a single heat-shock early in life. Here, we ask how multiple heat-shocks affect the mortality trajectory in nematodes and find increases of life expectancy of close to 50% and of maximum longevity as well. We examined mortality using large numbers of animals and found that multiple heat-shocks not only decrease initial mortality, but also slow the Gompertz rate of increase in mortality. Thus, multiple heat-shocks have anti-aging hormetic effects and represent an effective approach for modulating aging.

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Published In

Experimental gerontology

DOI

EISSN

1873-6815

ISSN

0531-5565

Publication Date

September 2009

Volume

44

Issue

9

Start / End Page

607 / 612

Related Subject Headings

  • Survival Analysis
  • Stress, Physiological
  • Longevity
  • Hot Temperature
  • Heat-Shock Response
  • Heat-Shock Proteins
  • Gerontology
  • Caenorhabditis elegans
  • Animals
  • Aging
 

Citation

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Wu, D., Cypser, J. R., Yashin, A. I., & Johnson, T. E. (2009). Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans. Experimental Gerontology, 44(9), 607–612. https://doi.org/10.1016/j.exger.2009.06.007
Wu, Deqing, James R. Cypser, Anatoli I. Yashin, and Thomas E. Johnson. “Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans.Experimental Gerontology 44, no. 9 (September 2009): 607–12. https://doi.org/10.1016/j.exger.2009.06.007.
Wu D, Cypser JR, Yashin AI, Johnson TE. Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans. Experimental gerontology. 2009 Sep;44(9):607–12.
Wu, Deqing, et al. “Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans.Experimental Gerontology, vol. 44, no. 9, Sept. 2009, pp. 607–12. Epmc, doi:10.1016/j.exger.2009.06.007.
Wu D, Cypser JR, Yashin AI, Johnson TE. Multiple mild heat-shocks decrease the Gompertz component of mortality in Caenorhabditis elegans. Experimental gerontology. 2009 Sep;44(9):607–612.
Journal cover image

Published In

Experimental gerontology

DOI

EISSN

1873-6815

ISSN

0531-5565

Publication Date

September 2009

Volume

44

Issue

9

Start / End Page

607 / 612

Related Subject Headings

  • Survival Analysis
  • Stress, Physiological
  • Longevity
  • Hot Temperature
  • Heat-Shock Response
  • Heat-Shock Proteins
  • Gerontology
  • Caenorhabditis elegans
  • Animals
  • Aging