Changes in CD4+ T-cell differentiation phenotype during structured treatment interruption in patients with chronic HIV-1 infection.

Published

Journal Article

Markers of maturation and activation were measured on peripheral CD4+ T cells in chronically HIV-1-infected patients in a randomized, controlled pilot study of structured treatment interruption (STI). Eight subjects underwent 2 cycles of 1 month off and 1 month on highly active antiretroviral therapy (HAART), followed by a final 3-month interruption. During STI, CD4+ T-cell percentage remained relatively stable in 4 of 8 subjects. The remaining 4 STI subjects had significant rapid decline in CD4+ T-cell percentage during STI, followed by return to pre-STI baseline while on HAART. Changes in overall CD4+ T-cell percentage corresponded with fluctuations in the CD45RA+CCR7+ naive and CD45RA-CCR7+ central memory subsets. Subjects with variable CD4+ T-cell percentages tended to have higher pre-HAART plasma HIV-1 RNA set-points and experienced higher levels of plasma HIV-1 RNA rebound during STI. These results suggest that interruptions should be avoided whenever possible in patients on HAART with high plasma HIV-1 RNA set-points.

Full Text

Duke Authors

Cited Authors

  • Alexander, TH; Ortiz, GM; Wellons, MF; Allen, A; Grace, EJ; Schweighardt, B; Brancato, J; Sandberg, JK; Furlan, SN; Miralles, GD; Nixon, DF; Bartlett, JA

Published Date

  • December 15, 2003

Published In

Volume / Issue

  • 34 / 5

Start / End Page

  • 475 - 481

PubMed ID

  • 14657757

Pubmed Central ID

  • 14657757

International Standard Serial Number (ISSN)

  • 1525-4135

Digital Object Identifier (DOI)

  • 10.1097/00126334-200312150-00005

Language

  • eng

Conference Location

  • United States