Overview
My research focuses on developing new statistical methods for identifying susceptibility loci involved in complex human disease. It involves a mix of genetics, statistics, and computer science and is motivated by the complexities of real data encountered in collaborative disease-gene mapping projects.
Current Appointments & Affiliations
Professor of Biostatistics & Bioinformatics
·
2019 - Present
Biostatistics & Bioinformatics, Division of Integrative Genomics,
Biostatistics & Bioinformatics
Director, Center for Statistical Genetics and Genomics
·
2015 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Chief, Division of Integrative Genomics
·
2018 - Present
Biostatistics & Bioinformatics, Division of Biostatistics,
Biostatistics & Bioinformatics
Recent Publications
Cell Modeling and Rescue of a Novel Non-coding Genetic Cause of Glycogen Storage Disease IX.
Preprint · May 17, 2025 Full text Link to item CiteCharacterization and bioinformatic filtering of ambient gRNAs in single-cell CRISPR screens using CLEANSER.
Journal Article Cell Genom · February 12, 2025 Single-cell RNA sequencing CRISPR (perturb-seq) screens enable high-throughput investigation of the genome, allowing for characterization of thousands of genomic perturbations on gene expression. Ambient gRNAs, which are contaminating gRNAs, are a major so ... Full text Link to item CitePromoter Deletion Leading to Allele Specific Expression in a Genetically Unsolved Case of Primary Ciliary Dyskinesia.
Journal Article Am J Med Genet A · February 2025 Variation in the non-coding genome represents an understudied mechanism of disease and it remains challenging to predict if single nucleotide variants, small insertions and deletions, or structural variants in non-coding genomic regions will be detrimental ... Full text Link to item CiteRecent Grants
Determining the genetic and social determinants of heart failure and mortality in patients with congenital heart disease
ResearchCo Investigator · Awarded by National Institutes of Health · 2023 - 2028Complement Pathway Activation in Idiopathic Pulmonary Fibrosis and other Progressive Fibrosing Interstitial Lung Diseases (K23)
ResearchAdvisor · Awarded by National Heart, Lung, and Blood Institute · 2023 - 2028Integrated Biostatistical Training for CVD Research
Inst. Training Prgm or CMEMentor · Awarded by North Carolina State University · 2022 - 2027View All Grants
Education, Training & Certifications
Emory University ·
2001
Ph.D.