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64-section multidetector CT of the upper abdomen: optimization of a saline chaser injection protocol for improved vascular and parenchymal contrast enhancement.

Publication ,  Journal Article
Marin, D; Nelson, RC; Guerrisi, A; Barnhart, H; Schindera, ST; Passariello, R; Catalano, C
Published in: Eur Radiol
September 2011

OBJECTIVES: To prospectively investigate the effect of varying the injection flow rates of a saline chaser on vascular and parenchymal contrast enhancement during abdominal MDCT. METHODS: 100 consecutive patients were randomly assigned to four injection protocols. A fixed dose of contrast medium was administered followed by no saline (Protocol A) or 50 mL of saline at 2, 4, or 8 mL/s (Protocols B, C, and D). Peak, time-to-peak, and duration of 90% peak enhancement were determined for aorta, pancreas, and liver. RESULTS: Aortic peak enhancement was significantly higher for Protocol D (369.5 HU) compared with Protocols A and B (332.9 HU and 326.0 HU, respectively; P < 0.05). Pancreatic peak enhancement was significantly higher for Protocols C and D (110.6 HU and 110.9 HU, respectively) compared to Protocol A (92.5 HU; P < 0.05). Aortic and pancreatic time-to-peak enhancement occurred significantly later for Protocol D compared with Protocol A (42.8 s vs. 36.1 s [P < 0.001] and 49.7 s vs. 45.3 s [P = 0.003]). CONCLUSIONS: Injecting a saline chaser at high flow rates yields significantly higher peak aortic and pancreatic enhancement, with a slight longer time-to-peak enhancement.

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Published In

Eur Radiol

DOI

EISSN

1432-1084

Publication Date

September 2011

Volume

21

Issue

9

Start / End Page

1938 / 1947

Location

Germany

Related Subject Headings

  • Young Adult
  • Tomography, Spiral Computed
  • Sodium Chloride
  • Sensitivity and Specificity
  • Reference Values
  • Radiographic Image Enhancement
  • Prospective Studies
  • Pancreas
  • Nuclear Medicine & Medical Imaging
  • Middle Aged
 

Citation

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Marin, D., Nelson, R. C., Guerrisi, A., Barnhart, H., Schindera, S. T., Passariello, R., & Catalano, C. (2011). 64-section multidetector CT of the upper abdomen: optimization of a saline chaser injection protocol for improved vascular and parenchymal contrast enhancement. Eur Radiol, 21(9), 1938–1947. https://doi.org/10.1007/s00330-011-2139-x
Marin, Daniele, Rendon C. Nelson, Antonino Guerrisi, Huiman Barnhart, Sebastian T. Schindera, Roberto Passariello, and Carlo Catalano. “64-section multidetector CT of the upper abdomen: optimization of a saline chaser injection protocol for improved vascular and parenchymal contrast enhancement.Eur Radiol 21, no. 9 (September 2011): 1938–47. https://doi.org/10.1007/s00330-011-2139-x.
Marin D, Nelson RC, Guerrisi A, Barnhart H, Schindera ST, Passariello R, et al. 64-section multidetector CT of the upper abdomen: optimization of a saline chaser injection protocol for improved vascular and parenchymal contrast enhancement. Eur Radiol. 2011 Sep;21(9):1938–47.
Marin, Daniele, et al. “64-section multidetector CT of the upper abdomen: optimization of a saline chaser injection protocol for improved vascular and parenchymal contrast enhancement.Eur Radiol, vol. 21, no. 9, Sept. 2011, pp. 1938–47. Pubmed, doi:10.1007/s00330-011-2139-x.
Marin D, Nelson RC, Guerrisi A, Barnhart H, Schindera ST, Passariello R, Catalano C. 64-section multidetector CT of the upper abdomen: optimization of a saline chaser injection protocol for improved vascular and parenchymal contrast enhancement. Eur Radiol. 2011 Sep;21(9):1938–1947.
Journal cover image

Published In

Eur Radiol

DOI

EISSN

1432-1084

Publication Date

September 2011

Volume

21

Issue

9

Start / End Page

1938 / 1947

Location

Germany

Related Subject Headings

  • Young Adult
  • Tomography, Spiral Computed
  • Sodium Chloride
  • Sensitivity and Specificity
  • Reference Values
  • Radiographic Image Enhancement
  • Prospective Studies
  • Pancreas
  • Nuclear Medicine & Medical Imaging
  • Middle Aged