Mapping human genetic diversity in Asia.
Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.
HUGO Pan-Asian SNP Consortium, ; Abdulla, MA; Ahmed, I; Assawamakin, A; Bhak, J; Brahmachari, SK; Calacal, GC; Chaurasia, A; Chen, C-H; Chen, J; Chen, Y-T; Chu, J; Cutiongco-de la Paz, EMC; De Ungria, MCA; Delfin, FC; Edo, J; Fuchareon, S; Ghang, H; Gojobori, T; Han, J; Ho, S-F; Hoh, BP; Huang, W; Inoko, H; Jha, P; Jinam, TA; Jin, L; Jung, J; Kangwanpong, D; Kampuansai, J; Kennedy, GC; Khurana, P; Kim, H-L; Kim, K; Kim, S; Kim, W-Y; Kimm, K; Kimura, R; Koike, T; Kulawonganunchai, S; Kumar, V; Lai, PS; Lee, J-Y; Lee, S; Liu, ET; Majumder, PP; Mandapati, KK; Marzuki, S; Mitchell, W; Mukerji, M; Naritomi, K; Ngamphiw, C; Niikawa, N; Nishida, N; Oh, B; Oh, S; Ohashi, J; Oka, A; Ong, R; Padilla, CD; Palittapongarnpim, P; Perdigon, HB; Phipps, ME; Png, E; Sakaki, Y; Salvador, JM; Sandraling, Y; Scaria, V; Seielstad, M; Sidek, MR; Sinha, A; Srikummool, M; Sudoyo, H; Sugano, S; Suryadi, H; Suzuki, Y; Tabbada, KA; Tan, A; Tokunaga, K; Tongsima, S; Villamor, LP; Wang, E; Wang, Y; Wang, H; Wu, J-Y; Xiao, H; Xu, S; Yang, JO; Shugart, YY; Yoo, H-S; Yuan, W; Zhao, G; Zilfalil, BA; Indian Genome Variation Consortium,
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