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Mapping human genetic diversity in Asia.

Publication ,  Journal Article
HUGO Pan-Asian SNP Consortium; Abdulla, MA; Ahmed, I; Assawamakin, A; Bhak, J; Brahmachari, SK; Calacal, GC; Chaurasia, A; Chen, C-H; Chen, J ...
Published in: Science
December 11, 2009
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Asia harbors substantial cultural and linguistic diversity, but the geographic structure of genetic variation across the continent remains enigmatic. Here we report a large-scale survey of autosomal variation from a broad geographic sample of Asian human populations. Our results show that genetic ancestry is strongly correlated with linguistic affiliations as well as geography. Most populations show relatedness within ethnic/linguistic groups, despite prevalent gene flow among populations. More than 90% of East Asian (EA) haplotypes could be found in either Southeast Asian (SEA) or Central-South Asian (CSA) populations and show clinal structure with haplotype diversity decreasing from south to north. Furthermore, 50% of EA haplotypes were found in SEA only and 5% were found in CSA only, indicating that SEA was a major geographic source of EA populations.

Duke Scholars

Yuan-Tsong Chen
Author Yuan-Tsong Chen Pediatrics, Medical Genetics
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Published In

Science

DOI

10.1126/science.1177074

EISSN

1095-9203

Publication Date

December 11, 2009

Volume

326

Issue

5959

Start / End Page

1541 / 1545

Location

United States

Related Subject Headings

  • Principal Component Analysis
  • Polymorphism, Single Nucleotide
  • Phylogeny
  • Oligonucleotide Array Sequence Analysis
  • Linguistics
  • Language
  • Humans
  • History, Ancient
  • Haplotypes
  • Geography
 

Citation

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HUGO Pan-Asian SNP Consortium, Abdulla, M. A., Ahmed, I., Assawamakin, A., Bhak, J., Brahmachari, S. K., … Indian Genome Variation Consortium. (2009). Mapping human genetic diversity in Asia. Science, 326(5959), 1541–1545. https://doi.org/10.1126/science.1177074
HUGO Pan-Asian SNP Consortium, Mahmood Ameen Abdulla, Ikhlak Ahmed, Anunchai Assawamakin, Jong Bhak, Samir K. Brahmachari, Gayvelline C. Calacal, et al. “Mapping human genetic diversity in Asia.” Science 326, no. 5959 (December 11, 2009): 1541–45. https://doi.org/10.1126/science.1177074.
HUGO Pan-Asian SNP Consortium, Abdulla MA, Ahmed I, Assawamakin A, Bhak J, Brahmachari SK, et al. Mapping human genetic diversity in Asia. Science. 2009 Dec 11;326(5959):1541–5.
HUGO Pan-Asian SNP Consortium, et al. “Mapping human genetic diversity in Asia.” Science, vol. 326, no. 5959, Dec. 2009, pp. 1541–45. Pubmed, doi:10.1126/science.1177074.
HUGO Pan-Asian SNP Consortium, Abdulla MA, Ahmed I, Assawamakin A, Bhak J, Brahmachari SK, Calacal GC, Chaurasia A, Chen C-H, Chen J, Chen Y-T, Chu J, Cutiongco-de la Paz EMC, De Ungria MCA, Delfin FC, Edo J, Fuchareon S, Ghang H, Gojobori T, Han J, Ho S-F, Hoh BP, Huang W, Inoko H, Jha P, Jinam TA, Jin L, Jung J, Kangwanpong D, Kampuansai J, Kennedy GC, Khurana P, Kim H-L, Kim K, Kim S, Kim W-Y, Kimm K, Kimura R, Koike T, Kulawonganunchai S, Kumar V, Lai PS, Lee J-Y, Lee S, Liu ET, Majumder PP, Mandapati KK, Marzuki S, Mitchell W, Mukerji M, Naritomi K, Ngamphiw C, Niikawa N, Nishida N, Oh B, Oh S, Ohashi J, Oka A, Ong R, Padilla CD, Palittapongarnpim P, Perdigon HB, Phipps ME, Png E, Sakaki Y, Salvador JM, Sandraling Y, Scaria V, Seielstad M, Sidek MR, Sinha A, Srikummool M, Sudoyo H, Sugano S, Suryadi H, Suzuki Y, Tabbada KA, Tan A, Tokunaga K, Tongsima S, Villamor LP, Wang E, Wang Y, Wang H, Wu J-Y, Xiao H, Xu S, Yang JO, Shugart YY, Yoo H-S, Yuan W, Zhao G, Zilfalil BA, Indian Genome Variation Consortium. Mapping human genetic diversity in Asia. Science. 2009 Dec 11;326(5959):1541–1545.
Journal cover image

Published In

Science

DOI

10.1126/science.1177074

EISSN

1095-9203

Publication Date

December 11, 2009

Volume

326

Issue

5959

Start / End Page

1541 / 1545

Location

United States

Related Subject Headings

  • Principal Component Analysis
  • Polymorphism, Single Nucleotide
  • Phylogeny
  • Oligonucleotide Array Sequence Analysis
  • Linguistics
  • Language
  • Humans
  • History, Ancient
  • Haplotypes
  • Geography