Medical genetics: a marker for Stevens-Johnson syndrome.
Journal Article (Journal Article)
Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens-Johnson syndrome.
- Chung, W-H; Hung, S-I; Hong, H-S; Hsih, M-S; Yang, L-C; Ho, H-C; Wu, J-Y; Chen, Y-T
- April 1, 2004
Volume / Issue
- 428 / 6982
Start / End Page
- 486 -
Electronic International Standard Serial Number (EISSN)
Digital Object Identifier (DOI)