Medical genetics: a marker for Stevens-Johnson syndrome.
Publication
, Journal Article
Chung, W-H; Hung, S-I; Hong, H-S; Hsih, M-S; Yang, L-C; Ho, H-C; Wu, J-Y; Chen, Y-T
Published in: Nature
April 1, 2004
Stevens-Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA-B*1502, and Stevens-Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse reaction, as well as for investigation of the pathogenesis of Stevens-Johnson syndrome.
Duke Scholars
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Published In
Nature
DOI
EISSN
1476-4687
Publication Date
April 1, 2004
Volume
428
Issue
6982
Start / End Page
486
Location
England
Related Subject Headings
- White People
- Stevens-Johnson Syndrome
- Incidence
- Humans
- HLA-B15 Antigen
- HLA-B Antigens
- General Science & Technology
- Diethylcarbamazine
- China
- Asian People
Citation
APA
Chicago
ICMJE
MLA
NLM
Chung, W.-H., Hung, S.-I., Hong, H.-S., Hsih, M.-S., Yang, L.-C., Ho, H.-C., … Chen, Y.-T. (2004). Medical genetics: a marker for Stevens-Johnson syndrome. Nature, 428(6982), 486. https://doi.org/10.1038/428486a
Chung, Wen-Hung, Shuen-Iu Hung, Hong-Shang Hong, Mo-Song Hsih, Li-Cheng Yang, Hsin-Chun Ho, Jer-Yuarn Wu, and Yuan-Tsong Chen. “Medical genetics: a marker for Stevens-Johnson syndrome.” Nature 428, no. 6982 (April 1, 2004): 486. https://doi.org/10.1038/428486a.
Chung W-H, Hung S-I, Hong H-S, Hsih M-S, Yang L-C, Ho H-C, et al. Medical genetics: a marker for Stevens-Johnson syndrome. Nature. 2004 Apr 1;428(6982):486.
Chung, Wen-Hung, et al. “Medical genetics: a marker for Stevens-Johnson syndrome.” Nature, vol. 428, no. 6982, Apr. 2004, p. 486. Pubmed, doi:10.1038/428486a.
Chung W-H, Hung S-I, Hong H-S, Hsih M-S, Yang L-C, Ho H-C, Wu J-Y, Chen Y-T. Medical genetics: a marker for Stevens-Johnson syndrome. Nature. 2004 Apr 1;428(6982):486.
Published In
Nature
DOI
EISSN
1476-4687
Publication Date
April 1, 2004
Volume
428
Issue
6982
Start / End Page
486
Location
England
Related Subject Headings
- White People
- Stevens-Johnson Syndrome
- Incidence
- Humans
- HLA-B15 Antigen
- HLA-B Antigens
- General Science & Technology
- Diethylcarbamazine
- China
- Asian People