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Outcomes of autologous and allogeneic blood or marrow transplantation for mantle cell lymphoma.

Publication ,  Journal Article
Kasamon, YL; Jones, RJ; Diehl, LF; Nayer, H; Borowitz, MJ; Garrett-Mayer, E; Ambinder, RF; Abrams, RA; Zhang, Z; Flinn, IW
Published in: Biol Blood Marrow Transplant
January 2005

To evaluate high-dose therapy and autologous or allogeneic blood or marrow transplantation (BMT) for mantle cell lymphoma, patients receiving BMT for newly diagnosed or relapsed mantle cell lymphoma were identified through the registry at Johns Hopkins. The pathologic diagnostic criteria were reviewed, and details of the presentation, transplant procedure, and survival outcomes were determined. Fifty-eight patients were identified, of whom 64% underwent transplantation in first remission and 12% had primary induction failure. Nineteen patients (one third) received an allograft. Preparative regimens consisted of cyclophosphamide in combination with either busulfan or total body irradiation. On multiple regression analysis, transplantation after 1 or more relapses (hazard ratio, 2.98; P = .02), primary induction failure (hazard ratio, 5.39; P = .002), and allogeneic transplantation (hazard ratio, 3.03; P = .007) were associated with an inferior event-free survival (EFS). However, EFS curves were not statistically different for autologous and allogeneic BMT performed in first remission, with an estimated 3-year EFS approaching or equaling 70%. Primary induction failure and residual bone marrow involvement were the only statistically significant predictors of relapse on multiple regression analysis. At 3 years, the estimated EFS for the entire cohort after BMT was 51%, the probability of relapse was 31%, and the overall survival was 59%. The benefit of autologous or allogeneic BMT for mantle cell lymphoma is thus most apparent when transplantation is performed in first remission. Whether allogeneic BMT ultimately confers an advantage because of a graft-versus-lymphoma effect remains to be determined.

Duke Scholars

Published In

Biol Blood Marrow Transplant

DOI

ISSN

1083-8791

Publication Date

January 2005

Volume

11

Issue

1

Start / End Page

39 / 46

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Homologous
  • Transplantation, Autologous
  • Survival Analysis
  • Retrospective Studies
  • Regression Analysis
  • Prognosis
  • Probability
  • Peripheral Blood Stem Cell Transplantation
  • Middle Aged
 

Citation

APA
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ICMJE
MLA
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Kasamon, Y. L., Jones, R. J., Diehl, L. F., Nayer, H., Borowitz, M. J., Garrett-Mayer, E., … Flinn, I. W. (2005). Outcomes of autologous and allogeneic blood or marrow transplantation for mantle cell lymphoma. Biol Blood Marrow Transplant, 11(1), 39–46. https://doi.org/10.1016/j.bbmt.2004.09.007
Kasamon, Yvette L., Richard J. Jones, Louis F. Diehl, Hassan Nayer, Michael J. Borowitz, Elizabeth Garrett-Mayer, Richard F. Ambinder, Ross A. Abrams, Zhe Zhang, and Ian W. Flinn. “Outcomes of autologous and allogeneic blood or marrow transplantation for mantle cell lymphoma.Biol Blood Marrow Transplant 11, no. 1 (January 2005): 39–46. https://doi.org/10.1016/j.bbmt.2004.09.007.
Kasamon YL, Jones RJ, Diehl LF, Nayer H, Borowitz MJ, Garrett-Mayer E, et al. Outcomes of autologous and allogeneic blood or marrow transplantation for mantle cell lymphoma. Biol Blood Marrow Transplant. 2005 Jan;11(1):39–46.
Kasamon, Yvette L., et al. “Outcomes of autologous and allogeneic blood or marrow transplantation for mantle cell lymphoma.Biol Blood Marrow Transplant, vol. 11, no. 1, Jan. 2005, pp. 39–46. Pubmed, doi:10.1016/j.bbmt.2004.09.007.
Kasamon YL, Jones RJ, Diehl LF, Nayer H, Borowitz MJ, Garrett-Mayer E, Ambinder RF, Abrams RA, Zhang Z, Flinn IW. Outcomes of autologous and allogeneic blood or marrow transplantation for mantle cell lymphoma. Biol Blood Marrow Transplant. 2005 Jan;11(1):39–46.
Journal cover image

Published In

Biol Blood Marrow Transplant

DOI

ISSN

1083-8791

Publication Date

January 2005

Volume

11

Issue

1

Start / End Page

39 / 46

Location

United States

Related Subject Headings

  • Treatment Outcome
  • Transplantation, Homologous
  • Transplantation, Autologous
  • Survival Analysis
  • Retrospective Studies
  • Regression Analysis
  • Prognosis
  • Probability
  • Peripheral Blood Stem Cell Transplantation
  • Middle Aged