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Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs.

Publication ,  Journal Article
Yi, R; O'Carroll, D; Pasolli, HA; Zhang, Z; Dietrich, FS; Tarakhovsky, A; Fuchs, E
Published in: Nat Genet
March 2006

During embryogenesis, multipotent progenitors within the single-layered surface epithelium differentiate to form the epidermis and its appendages. Here, we show that microRNAs (miRNAs) have an essential role in orchestrating these events. We cloned more than 100 miRNAs from skin and show that epidermis and hair follicles differentially express discrete miRNA families. To explore the functional significance of this finding, we conditionally targeted Dicer1 gene ablation in embryonic skin progenitors. Within the first week after loss of miRNA expression, cell fate specification and differentiation were not markedly impaired, and in the interfollicular epidermis, apoptosis was not markedly increased. Notably, however, developing hair germs evaginate rather than invaginate, thereby perturbing the epidermal organization. Here we characterize miRNAs in skin, the existence of which was hitherto unappreciated, and demonstrate their differential expression and importance in the morphogenesis of epithelial tissues within this vital organ.

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Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

March 2006

Volume

38

Issue

3

Start / End Page

356 / 362

Location

United States

Related Subject Headings

  • Skin
  • Ribonuclease III
  • Morphogenesis
  • MicroRNAs
  • Mice, Knockout
  • Mice
  • Hair Follicle
  • Gene Expression Regulation, Developmental
  • Epidermis
  • Embryonic Development
 

Citation

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Yi, R., O’Carroll, D., Pasolli, H. A., Zhang, Z., Dietrich, F. S., Tarakhovsky, A., & Fuchs, E. (2006). Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet, 38(3), 356–362. https://doi.org/10.1038/ng1744
Yi, Rui, Dónal O’Carroll, Hilda A. Pasolli, Zhihong Zhang, Fred S. Dietrich, Alexander Tarakhovsky, and Elaine Fuchs. “Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs.Nat Genet 38, no. 3 (March 2006): 356–62. https://doi.org/10.1038/ng1744.
Yi R, O’Carroll D, Pasolli HA, Zhang Z, Dietrich FS, Tarakhovsky A, et al. Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet. 2006 Mar;38(3):356–62.
Yi, Rui, et al. “Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs.Nat Genet, vol. 38, no. 3, Mar. 2006, pp. 356–62. Pubmed, doi:10.1038/ng1744.
Yi R, O’Carroll D, Pasolli HA, Zhang Z, Dietrich FS, Tarakhovsky A, Fuchs E. Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs. Nat Genet. 2006 Mar;38(3):356–362.

Published In

Nat Genet

DOI

ISSN

1061-4036

Publication Date

March 2006

Volume

38

Issue

3

Start / End Page

356 / 362

Location

United States

Related Subject Headings

  • Skin
  • Ribonuclease III
  • Morphogenesis
  • MicroRNAs
  • Mice, Knockout
  • Mice
  • Hair Follicle
  • Gene Expression Regulation, Developmental
  • Epidermis
  • Embryonic Development