Fred Samuel Dietrich
Associate Professor of Molecular Genetics and Microbiology
My laboratory is interested in fungal genomics.
In particular we use genomic sequencing of fungal strains and species in comparative analysis. Starting with the sequencing of Saccharomyces cerevisiae strain S288C, I have been involved in the genome sequencing and annotation of Ashbya gossypii, Cryptococcus neoformans var. grubii and ~100 additional S. cerevisiae strains. We currently use Illumina paired end and mate paired sequencing, as this is at presently the most cost effective widely used technology capable of generating high accuracy, zero gap whole genome sequences. The 100-genomes S. cerevisiae data as well as the fully updated fully annotated A. gossypii sequence (Genbank numbers AE016814-AE016820), which spans all seven chromosomes from telomere to telomere, were generated using Illumina data. In my laboratory we strive to utilize comparative genomics data to understand aspects of basic fungal biology. Some of our specific areas of interest are filamentous growth, mapping of complex traits, horizontal gene transfer, and identification of RNA coding genes. This work involves a combination of experimental work and bioinformatics analysis. Research in S. cerevisiae has greatly benefitted from an accurate, annotated S. cerevisiae reference genome, and that research into the tremendous diversity in this organism will similarly benefit from the availability of a large number of accurate, fully annotated genome sequences. The use of genomic information to better understand the biology of these organisms, and this is what students in my laboratory generally work on.
What is the set of genes found in a pathogenic fungus such as Cryptococcus?
Our interest in this human pathogen is to expand beyond looking at one isolate and to investigate the diversity in the population. Are there genes found in some Cryptococcus neoformans isolates but not in others? Are there regions of the genome or individual genes which are highly diverged between Cryptococcus isolates? Efforts are now underway at Stanford University to sequence the genome of the JEC21 strain of Cryptococcus. This is a strain that has been agreed upon by the community of Cryptococcus researchers as a reference strain. Obtaining the DNA sequence of this strain is only the start however. From that sequence identifying the complete set of genes will be a considerable challenge requiring both bioinformatic as well as experimental tools. While this work on gene identification is going on we plan on addressing the question of how much do other Cryptococcus isolates differ from JEC21.
What is the set of genes in humans?
The complete DNA sequence of human and mouse will become available soon. This does not mean that we will know the complete set of human or mouse genes. Our current state of knowledge does not allow us to accurately predict human genes directly from DNA sequence. We are interested in applying to the human genome some of the experimental and bioinformatic tools we are developing and utilizing in fungal systems.
Current Appointments & Affiliations
- Associate Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2007
Contact Information
- 421 Jones Building, Durham, NC 27710
- Duke Box 3568, Durham, NC 27710
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fred.dietrich@duke.edu
(919) 684-2857
- Background
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Education, Training, & Certifications
- Head, DNA Sequencing Center, Dna Sequencing Ctr, Stanford University 1994 - 1996
- Ph.D., Massachusetts Institute of Technology 1996
- Research Associate, Biology, Massachusetts Institute of Technology 1992 - 1994
- B.S., University of California - Davis 1985
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Previous Appointments & Affiliations
- Assistant Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2002 - 2007
- Assistant Professor of Genetics, School of Medicine, Duke University 2000 - 2002
- Adjunct Assistant Professor of Genetics, School of Medicine, Duke University 2000
- Recognition
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In the News
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APR 18, 2014 U.S. News & World Report -
APR 18, 2014 U.S. News & World Report -
APR 17, 2014
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- Expertise
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Subject Headings
- Research
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Selected Grants
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Transplant Infectious Diseases Interdisciplinary Research Training Grant (TIDIRTG) awarded by National Institutes of Health 2018 - 2023
- Preparing Genetic Counselors for Genomic Medicine Research awarded by National Institutes of Health 2017 - 2023
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pathobiology of C. neoformans in the Central Nervous System awarded by National Institutes of Health 2014 - 2020
- High throughput S. cerevisiae HAM, GWA & QT/QTL architecture awarded by National Institutes of Health 2011 - 2016
- Evolution of Cryptococcus neoformans strains from patients with HIV/AIDS awarded by National Institutes of Health 2011 - 2016
- Evolution of silencing proteins in yeast awarded by National Science Foundation 2011 - 2012
- Genetic Analysis in Chlamydia awarded by National Institutes of Health 2010 - 2012
- FIBR: Integrated Ecological and Genomic Analysis of Speciation in Mimulus awarded by National Science Foundation 2003 - 2010
- Genetic analysis of Cryptococcus neoformans virulence awarded by National Institutes of Health 2005 - 2010
- A Genomics Approach to Study C. neoformans var. grubii awarded by National Institutes of Health 2003 - 2008
- Duke/NIDDK Functional Genomics Center awarded by National Institutes of Health 2000 - 2003
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Telzrow, Calla L., Paul J. Zwack, Shannon Esher Righi, Fred S. Dietrich, Cliburn Chan, Kouros Owzar, J Andrew Alspaugh, and Joshua A. Granek. “Comparative analysis of RNA enrichment methods for preparation of Cryptococcus neoformans RNA sequencing libraries.” G3 (Bethesda) 11, no. 11 (October 19, 2021). https://doi.org/10.1093/g3journal/jkab301.Full Text Link to Item
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Ianiri, Giuseppe, Marco A. Coelho, Fiorella Ruchti, Florian Sparber, Timothy J. McMahon, Ci Fu, Madison Bolejack, et al. “HGT in the human and skin commensal Malassezia: A bacterially derived flavohemoglobin is required for NO resistance and host interaction.” Proc Natl Acad Sci U S A 117, no. 27 (July 7, 2020): 15884–94. https://doi.org/10.1073/pnas.2003473117.Full Text Open Access Copy Link to Item
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Armaleo, Daniele, Olaf Müller, François Lutzoni, Ólafur S. Andrésson, Guillaume Blanc, Helge B. Bode, Frank R. Collart, et al. “The lichen symbiosis re-viewed through the genomes of Cladonia grayi and its algal partner Asterochloris glomerata.” Bmc Genomics 20, no. 1 (July 23, 2019): 605. https://doi.org/10.1186/s12864-019-5629-x.Full Text Link to Item
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Vijayraghavan, Sriram, Stanislav G. Kozmin, Pooja K. Strope, Daniel A. Skelly, Zhenguo Lin, John Kennell, Paul M. Magwene, Fred S. Dietrich, and John H. McCusker. “Mitochondrial Genome Variation Affects Multiple Respiration and Nonrespiration Phenotypes in Saccharomyces cerevisiae.” Genetics 211, no. 2 (February 2019): 773–86. https://doi.org/10.1534/genetics.118.301546.Full Text Link to Item
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Strope, Pooja K., Stanislav G. Kozmin, Daniel A. Skelly, Paul M. Magwene, Fred S. Dietrich, and John H. McCusker. “2μ plasmid in Saccharomyces species and in Saccharomyces cerevisiae.” Fems Yeast Res 15, no. 8 (December 2015). https://doi.org/10.1093/femsyr/fov090.Full Text Link to Item
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Strope, Pooja K., Daniel A. Skelly, Stanislav G. Kozmin, Gayathri Mahadevan, Eric A. Stone, Paul M. Magwene, Fred S. Dietrich, and John H. McCusker. “The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen.” Genome Res 25, no. 5 (May 2015): 762–74. https://doi.org/10.1101/gr.185538.114.Full Text Link to Item
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Zhao, Ying, Pooja K. Strope, Stanislav G. Kozmin, John H. McCusker, Fred S. Dietrich, Robert J. Kokoska, and Thomas D. Petes. “Structures of naturally evolved CUP1 tandem arrays in yeast indicate that these arrays are generated by unequal nonhomologous recombination.” G3 (Bethesda) 4, no. 11 (September 17, 2014): 2259–69. https://doi.org/10.1534/g3.114.012922.Full Text Link to Item
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Springer, D. J., R. B. Billmyre, E. E. Filler, K. Voelz, R. Pursall, P. A. Mieczkowski, R. A. Larsen, et al. “Cryptococcus gattii VGIII Isolates Causing Infections in HIV/AIDS Patients in Southern California: Identification of the Local Environmental Source as Arboreal.” Plos Pathogens 10, no. 8 (August 21, 2014). https://doi.org/10.1371/journal.ppat.1004285.Full Text Open Access Copy
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Janbon, Guilhem, Kate L. Ormerod, Damien Paulet, Edmond J. Byrnes, Vikas Yadav, Gautam Chatterjee, Nandita Mullapudi, et al. “Analysis of the genome and transcriptome of Cryptococcus neoformans var. grubii reveals complex RNA expression and microevolution leading to virulence attenuation.” Plos Genet 10, no. 4 (April 2014): e1004261. https://doi.org/10.1371/journal.pgen.1004261.Full Text Open Access Copy Link to Item
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Engel, Stacia R., Fred S. Dietrich, Dianna G. Fisk, Gail Binkley, Rama Balakrishnan, Maria C. Costanzo, Selina S. Dwight, et al. “The reference genome sequence of Saccharomyces cerevisiae: then and now.” G3 (Bethesda) 4, no. 3 (March 20, 2014): 389–98. https://doi.org/10.1534/g3.113.008995.Full Text Link to Item
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Froyd, Cara A., Shivali Kapoor, Fred Dietrich, and Laura N. Rusche. “The deacetylase Sir2 from the yeast Clavispora lusitaniae lacks the evolutionarily conserved capacity to generate subtelomeric heterochromatin.” Plos Genet 9, no. 10 (October 2013): e1003935. https://doi.org/10.1371/journal.pgen.1003935.Full Text Link to Item
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Ni, Min, Marianna Feretzaki, Wenjun Li, Anna Floyd-Averette, Piotr Mieczkowski, Fred S. Dietrich, and Joseph Heitman. “Unisexual and heterosexual meiotic reproduction generate aneuploidy and phenotypic diversity de novo in the yeast Cryptococcus neoformans.” Plos Biol 11, no. 9 (September 2013): e1001653. https://doi.org/10.1371/journal.pbio.1001653.Full Text Link to Item
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Dietrich, Fred S., Sylvia Voegeli, Sidney Kuo, and Peter Philippsen. “Genomes of Ashbya fungi isolated from insects reveal four mating-type loci, numerous translocations, lack of transposons, and distinct gene duplications.” G3 (Bethesda) 3, no. 8 (August 7, 2013): 1225–39. https://doi.org/10.1534/g3.112.002881.Full Text Link to Item
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McDonald, Tami R., Olaf Mueller, Fred S. Dietrich, and François Lutzoni. “High-throughput genome sequencing of lichenizing fungi to assess gene loss in the ammonium transporter/ammonia permease gene family.” Bmc Genomics 14 (April 4, 2013): 225. https://doi.org/10.1186/1471-2164-14-225.Full Text Link to Item
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O’Meara, Teresa R., Stephanie M. Holmer, Kyla Selvig, Fred Dietrich, and J Andrew Alspaugh. “Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses.” Mbio 4, no. 1 (January 15, 2013). https://doi.org/10.1128/mBio.00522-12.Full Text Link to Item
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Martin, Michael D., Enrico Cappellini, Jose A. Samaniego, M Lisandra Zepeda, Paula F. Campos, Andaine Seguin-Orlando, Nathan Wales, et al. “Reconstructing genome evolution in historic samples of the Irish potato famine pathogen.” Nat Commun 4 (2013): 2172. https://doi.org/10.1038/ncomms3172.Full Text Link to Item
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St Charles, Jordan, Einat Hazkani-Covo, Yi Yin, Sabrina L. Andersen, Fred S. Dietrich, Patricia W. Greenwell, Ewa Malc, Piotr Mieczkowski, and Thomas D. Petes. “High-resolution genome-wide analysis of irradiated (UV and γ-rays) diploid yeast cells reveals a high frequency of genomic loss of heterozygosity (LOH) events.” Genetics 190, no. 4 (April 2012): 1267–84. https://doi.org/10.1534/genetics.111.137927.Full Text Link to Item
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Findley, Keisha, Sheng Sun, James A. Fraser, Yen-Ping Hsueh, Anna Floyd Averette, Wenjun Li, Fred S. Dietrich, and Joseph Heitman. “Discovery of a modified tetrapolar sexual cycle in Cryptococcus amylolentus and the evolution of MAT in the Cryptococcus species complex.” Plos Genet 8, no. 2 (2012): e1002528. https://doi.org/10.1371/journal.pgen.1002528.Full Text Link to Item
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McDonald, Tami R., Fred S. Dietrich, and François Lutzoni. “Multiple horizontal gene transfers of ammonium transporters/ammonia permeases from prokaryotes to eukaryotes: toward a new functional and evolutionary classification.” Mol Biol Evol 29, no. 1 (January 2012): 51–60. https://doi.org/10.1093/molbev/msr123.Full Text Link to Item
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Cirulli, Elizabeth T., Erin L. Heinzen, Fred S. Dietrich, Kevin V. Shianna, Abanish Singh, Jessica M. Maia, James J. Goedert, and David B. Goldstein. “A whole-genome analysis of premature termination codons.” Genomics 98, no. 5 (November 2011): 337–42. https://doi.org/10.1016/j.ygeno.2011.07.001.Full Text Link to Item
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Byrnes, Edmond J., Wenjun Li, Ping Ren, Yonathan Lewit, Kerstin Voelz, James A. Fraser, Fred S. Dietrich, et al. “A diverse population of Cryptococcus gattii molecular type VGIII in southern Californian HIV/AIDS patients.” Plos Pathog 7, no. 9 (September 2011): e1002205. https://doi.org/10.1371/journal.ppat.1002205.Full Text Link to Item
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Diezmann, Stephanie, and Fred S. Dietrich. “Oxidative stress survival in a clinical Saccharomyces cerevisiae isolate is influenced by a major quantitative trait nucleotide.” Genetics 188, no. 3 (July 2011): 709–22. https://doi.org/10.1534/genetics.111.128256.Full Text
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Stajich, Jason E., Sarah K. Wilke, Dag Ahrén, Chun Hang Au, Bruce W. Birren, Mark Borodovsky, Claire Burns, et al. “Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).” Proc Natl Acad Sci U S A 107, no. 26 (June 29, 2010): 11889–94. https://doi.org/10.1073/pnas.1003391107.Full Text Link to Item
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Lee, Soo Chan, Nicolas Corradi, Sylvia Doan, Fred S. Dietrich, Patrick J. Keeling, and Joseph Heitman. “Evolution of the sex-related locus and genomic features shared in microsporidia and fungi.” Plos One 5, no. 5 (May 7, 2010): e10539. https://doi.org/10.1371/journal.pone.0010539.Full Text Open Access Copy Link to Item
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Rodriguez-Carres, Marianela, Keisha Findley, Sheng Sun, Fred S. Dietrich, and Joseph Heitman. “Morphological and genomic characterization of Filobasidiella depauperata: a homothallic sibling species of the pathogenic cryptococcus species complex.” Plos One 5, no. 3 (March 10, 2010): e9620. https://doi.org/10.1371/journal.pone.0009620.Full Text Open Access Copy Link to Item
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Argueso, Juan Lucas, Marcelo F. Carazzolle, Piotr A. Mieczkowski, Fabiana M. Duarte, Osmar V. C. Netto, Silvia K. Missawa, Felipe Galzerani, et al. “Genome structure of a Saccharomyces cerevisiae strain widely used in bioethanol production.” Genome Res 19, no. 12 (December 2009): 2258–70. https://doi.org/10.1101/gr.091777.109.Full Text Link to Item
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Diezmann, Stephanie, and Fred S. Dietrich. “Saccharomyces cerevisiae: population divergence and resistance to oxidative stress in clinical, domesticated and wild isolates.” Plos One 4, no. 4 (2009): e5317. https://doi.org/10.1371/journal.pone.0005317.Full Text Link to Item
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Kavanaugh, Laura A., and Fred S. Dietrich. “Non-coding RNA prediction and verification in Saccharomyces cerevisiae.” Plos Genet 5, no. 1 (January 2009): e1000321. https://doi.org/10.1371/journal.pgen.1000321.Full Text Link to Item
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Lee, Soo Chan, Nicolas Corradi, Edmond J. Byrnes, Santiago Torres-Martinez, Fred S. Dietrich, Patrick J. Keeling, and Joseph Heitman. “Microsporidia evolved from ancestral sexual fungi.” Curr Biol 18, no. 21 (November 11, 2008): 1675–79. https://doi.org/10.1016/j.cub.2008.09.030.Full Text Link to Item
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Hu, Guanggan, Iris Liu, Anita Sham, Jason E. Stajich, Fred S. Dietrich, and James W. Kronstad. “Comparative hybridization reveals extensive genome variation in the AIDS-associated pathogen Cryptococcus neoformans.” Genome Biol 9, no. 2 (2008): R41. https://doi.org/10.1186/gb-2008-9-2-r41.Full Text Link to Item
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Hall, Charles, and Fred S. Dietrich. “The reacquisition of biotin prototrophy in Saccharomyces cerevisiae involved horizontal gene transfer, gene duplication and gene clustering.” Genetics 177, no. 4 (December 2007): 2293–2307. https://doi.org/10.1534/genetics.107.074963.Full Text Link to Item
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Luedi, Philippe P., Fred S. Dietrich, Jennifer R. Weidman, Jason M. Bosko, Randy L. Jirtle, and Alexander J. Hartemink. “Computational and experimental identification of novel human imprinted genes.” Genome Res 17, no. 12 (December 2007): 1723–30. https://doi.org/10.1101/gr.6584707.Full Text Link to Item
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Wei, Wu, John H. McCusker, Richard W. Hyman, Ted Jones, Ye Ning, Zhiwei Cao, Zhenglong Gu, et al. “Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789.” Proc Natl Acad Sci U S A 104, no. 31 (July 31, 2007): 12825–30. https://doi.org/10.1073/pnas.0701291104.Full Text Link to Item
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Harrison, Luke B., Zhan Yu, Jason E. Stajich, Fred S. Dietrich, and Paul M. Harrison. “Evolution of budding yeast prion-determinant sequences across diverse fungi.” J Mol Biol 368, no. 1 (April 20, 2007): 273–82. https://doi.org/10.1016/j.jmb.2007.01.070.Full Text Link to Item
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Gattiker, Alexandre, Riccarda Rischatsch, Philippe Demougin, Sylvia Voegeli, Fred S. Dietrich, Peter Philippsen, and Michael Primig. “Ashbya Genome Database 3.0: a cross-species genome and transcriptome browser for yeast biologists.” Bmc Genomics 8 (January 9, 2007): 9. https://doi.org/10.1186/1471-2164-8-9.Full Text Link to Item
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Stajich, Jason E., Fred S. Dietrich, and Scott W. Roy. “Comparative genomic analysis of fungal genomes reveals intron-rich ancestors.” Genome Biol 8, no. 10 (2007): R223. https://doi.org/10.1186/gb-2007-8-10-r223.Full Text Link to Item
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Brachat, S., F. Dietrich, S. Voegeli, T. Gaffney, and P. Philippsen. “The genome of the filamentous fungus ashbya gossypii: Annotation and evolutionary implications.” Topics in Current Genetics 15 (December 1, 2006): 197–232. https://doi.org/10.1007/4735_114.Full Text
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Cramer, Robert A., Jason E. Stajich, Yvonne Yamanaka, Fred S. Dietrich, William J. Steinbach, and John R. Perfect. “Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus.” Gene 383 (November 15, 2006): 24–32. https://doi.org/10.1016/j.gene.2006.07.008.Full Text Link to Item
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Kavanaugh, Laura A., James A. Fraser, and Fred S. Dietrich. “Recent evolution of the human pathogen Cryptococcus neoformans by intervarietal transfer of a 14-gene fragment.” Mol Biol Evol 23, no. 10 (October 2006): 1879–90. https://doi.org/10.1093/molbev/msl070.Full Text Link to Item
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Giles, Steven S., Jason E. Stajich, Connie Nichols, Quincy D. Gerrald, J Andrew Alspaugh, Fred Dietrich, and John R. Perfect. “The Cryptococcus neoformans catalase gene family and its role in antioxidant defense.” Eukaryot Cell 5, no. 9 (September 2006): 1447–59. https://doi.org/10.1128/EC.00098-06.Full Text Link to Item
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Fraser, James A., Shirlene M. C. Lim, Stephanie Diezmann, Emily C. Wenink, Cristl G. Arndt, Gary M. Cox, Fred S. Dietrich, and Joseph Heitman. “Yeast diversity sampling on the San Juan Islands reveals no evidence for the spread of the Vancouver Island Cryptococcus gattii outbreak to this locale.” Fems Yeast Res 6, no. 4 (June 2006): 620–24. https://doi.org/10.1111/j.1567-1364.2006.00075.x.Full Text Link to Item
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Stajich, Jason E., and Fred S. Dietrich. “Evidence of mRNA-mediated intron loss in the human-pathogenic fungus Cryptococcus neoformans.” Eukaryot Cell 5, no. 5 (May 2006): 789–93. https://doi.org/10.1128/EC.5.5.789-793.2006.Full Text Link to Item
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Yi, Rui, Dónal O’Carroll, Hilda A. Pasolli, Zhihong Zhang, Fred S. Dietrich, Alexander Tarakhovsky, and Elaine Fuchs. “Morphogenesis in skin is governed by discrete sets of differentially expressed microRNAs.” Nat Genet 38, no. 3 (March 2006): 356–62. https://doi.org/10.1038/ng1744.Full Text Link to Item
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Fraser, James A., Steven S. Giles, Emily C. Wenink, Scarlett G. Geunes-Boyer, Jo Rae Wright, Stephanie Diezmann, Andria Allen, et al. “Same-sex mating and the origin of the Vancouver Island Cryptococcus gattii outbreak.” Nature 437, no. 7063 (October 27, 2005): 1360–64. https://doi.org/10.1038/nature04220.Full Text Link to Item
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Noureddine, Maher A., Yi-Ju Li, Joelle M. van der Walt, Robert Walters, Rita M. Jewett, Hong Xu, Tianyuan Wang, et al. “Genomic convergence to identify candidate genes for Parkinson disease: SAGE analysis of the substantia nigra.” Mov Disord 20, no. 10 (October 2005): 1299–1309. https://doi.org/10.1002/mds.20573.Full Text Link to Item
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Campbell, Leona T., James A. Fraser, Connie B. Nichols, Fred S. Dietrich, Dee Carter, and Joseph Heitman. “Clinical and environmental isolates of Cryptococcus gattii from Australia that retain sexual fecundity.” Eukaryot Cell 4, no. 8 (August 2005): 1410–19. https://doi.org/10.1128/EC.4.8.1410-1419.2005.Full Text Link to Item
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Zhang, Zhihong, and Fred S. Dietrich. “Identification and characterization of upstream open reading frames (uORF) in the 5' untranslated regions (UTR) of genes in Saccharomyces cerevisiae.” Curr Genet 48, no. 2 (August 2005): 77–87. https://doi.org/10.1007/s00294-005-0001-x.Full Text Link to Item
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Hall, Charles, Sophie Brachat, and Fred S. Dietrich. “Contribution of horizontal gene transfer to the evolution of Saccharomyces cerevisiae.” Eukaryot Cell 4, no. 6 (June 2005): 1102–15. https://doi.org/10.1128/EC.4.6.1102-1115.2005.Full Text Link to Item
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Zhang, Zhihong, and Fred S. Dietrich. “Mapping of transcription start sites in Saccharomyces cerevisiae using 5' SAGE.” Nucleic Acids Res 33, no. 9 (2005): 2838–51. https://doi.org/10.1093/nar/gki583.Full Text Link to Item
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Fraser, James A., Stephanie Diezmann, Ryan L. Subaran, Andria Allen, Klaus B. Lengeler, Fred S. Dietrich, and Joseph Heitman. “Convergent evolution of chromosomal sex-determining regions in the animal and fungal kingdoms.” Plos Biol 2, no. 12 (December 2004): e384. https://doi.org/10.1371/journal.pbio.0020384.Full Text Link to Item
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Kraus, Peter R., Marie-Josée Boily, Steven S. Giles, Jason E. Stajich, Andria Allen, Gary M. Cox, Fred S. Dietrich, John R. Perfect, and Joseph Heitman. “Identification of Cryptococcus neoformans temperature-regulated genes with a genomic-DNA microarray.” Eukaryot Cell 3, no. 5 (October 2004): 1249–60. https://doi.org/10.1128/EC.3.5.1249-1260.2004.Full Text Link to Item
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Toffaletti, Dena L., Kirsten Nielsen, Fred Dietrich, Joseph Heitman, and John R. Perfect. “Cryptococcus neoformans mitochondrial genomes from serotype A and D strains do not influence virulence.” Curr Genet 46, no. 4 (October 2004): 193–204. https://doi.org/10.1007/s00294-004-0521-9.Full Text Link to Item
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Weidman, Jennifer R., Susan K. Murphy, Catherine M. Nolan, Fred S. Dietrich, and Randy L. Jirtle. “Phylogenetic footprint analysis of IGF2 in extant mammals.” Genome Res 14, no. 9 (September 2004): 1726–32. https://doi.org/10.1101/gr.2774804.Full Text Link to Item
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Resch, Grégory, Eva M. Kulik, Fred S. Dietrich, and Jürg Meyer. “Complete genomic nucleotide sequence of the temperate bacteriophage Aa Phi 23 of Actinobacillus actinomycetemcomitans.” J Bacteriol 186, no. 16 (August 2004): 5523–28. https://doi.org/10.1128/JB.186.16.5523-5528.2004.Full Text Link to Item
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Dietrich, F. S. “Erratum: The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome (Science (April 9) (304)).” Science 304, no. 5670 (April 23, 2004): 518.
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Dietrich, Fred S., Sylvia Voegeli, Sophie Brachat, Anita Lerch, Krista Gates, Sabine Steiner, Christine Mohr, et al. “The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces cerevisiae genome.” Science 304, no. 5668 (April 9, 2004): 304–7. https://doi.org/10.1126/science.1095781.Full Text Link to Item
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Knechtle, Philipp, Fred Dietrich, and Peter Philippsen. “Maximal polar growth potential depends on the polarisome component AgSpa2 in the filamentous fungus Ashbya gossypii.” Mol Biol Cell 14, no. 10 (October 2003): 4140–54. https://doi.org/10.1091/mbc.e03-03-0167.Full Text Link to Item
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Zhang, Zhihong, and Fred S. Dietrich. “Verification of a new gene on Saccharomyces cerevisiae chromosome III.” Yeast 20, no. 8 (June 2003): 731–38. https://doi.org/10.1002/yea.996.Full Text Link to Item
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Toffaletti, Dena L., Maurizio Del Poeta, Thomas H. Rude, Fred Dietrich, and John R. Perfect. “Regulation of cytochrome c oxidase subunit 1 (COX1) expression in Cryptococcus neoformans by temperature and host environment.” Microbiology (Reading) 149, no. Pt 4 (April 2003): 1041–49. https://doi.org/10.1099/mic.0.26021-0.Full Text Link to Item
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Hauser, Michael A., Yi-Ju Li, Satoshi Takeuchi, Robert Walters, Maher Noureddine, Melinda Maready, Tiffany Darden, et al. “Genomic convergence: identifying candidate genes for Parkinson's disease by combining serial analysis of gene expression and genetic linkage.” Hum Mol Genet 12, no. 6 (March 15, 2003): 671–77.Link to Item
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Spell, R., F. Dietrich, and R. Brady. “BARD: A visualization tool for biological sequence analysis.” Proceedings Ieee Symposium on Information Visualization, Info Vis, January 1, 2003, 219–26. https://doi.org/10.1109/infvis.2003.1249029.Full Text
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Brachat, Sophie, Fred S. Dietrich, Sylvia Voegeli, Zhihong Zhang, Larissa Stuart, Anita Lerch, Krista Gates, Tom Gaffney, and Peter Philippsen. “Reinvestigation of the Saccharomyces cerevisiae genome annotation by comparison to the genome of a related fungus: Ashbya gossypii.” Genome Biol 4, no. 7 (2003): R45. https://doi.org/10.1186/gb-2003-4-7-r45.Full Text Link to Item
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Jarvis, E. D., V. A. Smith, K. Wada, M. V. Rivas, M. McElroy, T. V. Smulders, P. Carninci, et al. “A framework for integrating the songbird brain.” J Comp Physiol a Neuroethol Sens Neural Behav Physiol 188, no. 11–12 (December 2002): 961–80. https://doi.org/10.1007/s00359-002-0358-y.Full Text Open Access Copy Link to Item
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Lengeler, Klaus B., Deborah S. Fox, James A. Fraser, Andria Allen, Keri Forrester, Fred S. Dietrich, and Joseph Heitman. “Mating-type locus of Cryptococcus neoformans: a step in the evolution of sex chromosomes.” Eukaryot Cell 1, no. 5 (October 2002): 704–18. https://doi.org/10.1128/EC.1.5.704-718.2002.Full Text Link to Item
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Alberti-Segui, C., F. Dietrich, R. Altmann-Höhl, D. Hoepfner, and P. Philippsen. “Cytoplasmic dynein is required to oppose the force that moves nuclei towards the hypal tip in the filamentous ascomycete Ashbya gossypii.” Journal of Cell Science 114, no. 5 (April 17, 2001): 975–86.
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Alberti-Segui, C., F. Dietrich, R. Altmann-Jöhl, D. Hoepfner, and P. Philippsen. “Cytoplasmic dynein is required to oppose the force that moves nuclei towards the hyphal tip in the filamentous ascomycete Ashbya gossypii.” J Cell Sci 114, no. Pt 5 (March 2001): 975–86. https://doi.org/10.1242/jcs.114.5.975.Full Text Link to Item
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Ayad-Durieux, Y., P. Knechtle, S. Goff, F. Dietrich, and P. Philippsen. “A PAK-like protein kinase is required for maturation of young hyphae and septation in the filamentous ascomycete Ashbya gossypii.” J Cell Sci 113 Pt 24 (December 2000): 4563–75. https://doi.org/10.1242/jcs.113.24.4563.Full Text Link to Item
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Winzeler, E. A., D. D. Shoemaker, A. Astromoff, H. Liang, K. Anderson, B. Andre, R. Bangham, et al. “Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis.” Science 285, no. 5429 (August 6, 1999): 901–6. https://doi.org/10.1126/science.285.5429.901.Full Text Link to Item
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Wendland, J., R. Pöhlmann, F. Dietrich, S. Steiner, C. Mohr, and P. Philippsen. “Compact organization of rRNA genes in the filamentous fungus Ashbya gossypii.” Curr Genet 35, no. 6 (July 1999): 618–25. https://doi.org/10.1007/s002940050460.Full Text Link to Item
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Bussey, H., R. K. Storms, A. Ahmed, K. Albermann, E. Allen, W. Ansorge, R. Araujo, et al. “The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.” Nature 387, no. 6632 Suppl (May 29, 1997): 103–5.Link to Item
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Bussey, H., R. K. Storms, A. Ahmed, K. Albermann, E. Allen, W. Ansorge, R. Araujo, et al. “The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.” Nature 387, no. 6632 SUPPL. (May 29, 1997): 103–5. https://doi.org/10.1038/387s103.Full Text
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Dietrich, F. S., J. Mulligan, K. Hennessy, M. A. Yelton, E. Allen, R. Araujo, E. Aviles, et al. “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.” Nature 387, no. 6632 Suppl (May 29, 1997): 78–81.Link to Item
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Dietrich, F. S., J. Mulligan, K. Hennessy, M. A. Yelton, E. Allen, R. Araujo, E. Aviles, et al. “The nucleotide sequence of Saccharomyces cerevisiae chromosome V.” Nature 387, no. 6632 SUPPL. (May 29, 1997): 78–81. https://doi.org/10.1038/387s078.Full Text
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Jacq, C., J. Alt-Mörbe, B. Andre, W. Arnold, A. Bahr, J. P. Ballesta, M. Bargues, et al. “The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.” Nature 387, no. 6632 Suppl (May 29, 1997): 75–78.Link to Item
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Oefner, P. J., S. P. Hunicke-Smith, L. Chiang, F. Dietrich, J. Mulligan, and R. W. Davis. “Efficient random subcloning of DNA sheared in a recirculating point-sink flow system.” Nucleic Acids Res 24, no. 20 (October 15, 1996): 3879–86. https://doi.org/10.1093/nar/24.20.3879.Full Text Link to Item
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Navarre, C., P. Catty, S. Leterme, F. Dietrich, and A. Goffeau. “Two distinct genes encode small isoproteolipids affecting plasma membrane H(+)-ATPase activity of Saccharomyces cerevisiae.” J Biol Chem 269, no. 33 (August 19, 1994): 21262–68.Link to Item
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Christman, M. F., F. S. Dietrich, N. A. Levin, B. U. Sadoff, and G. R. Fink. “The rRNA-encoding DNA array has an altered structure in topoisomerase I mutants of Saccharomyces cerevisiae.” Proc Natl Acad Sci U S A 90, no. 16 (August 15, 1993): 7637–41. https://doi.org/10.1073/pnas.90.16.7637.Full Text Link to Item
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Christman, M. F., F. S. Dietrich, and G. R. Fink. “Mitotic recombination in the rDNA of S. cerevisiae is suppressed by the combined action of DNA topoisomerases I and II.” Cell 55, no. 3 (November 4, 1988): 413–25. https://doi.org/10.1016/0092-8674(88)90027-x.Full Text Link to Item
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